Motif ID: Nr2e3

Z-value: 0.926


Transcription factors associated with Nr2e3:

Gene SymbolEntrez IDGene Name
Nr2e3 ENSMUSG00000032292.2 Nr2e3



Activity profile for motif Nr2e3.

activity profile for motif Nr2e3


Sorted Z-values histogram for motif Nr2e3

Sorted Z-values for motif Nr2e3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e3

PNG image of the network

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Top targets:


Showing 1 to 20 of 163 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_35215008 17.595 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr6_+_141524379 11.680 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr6_-_13839916 10.565 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr3_+_76074270 10.519 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr1_+_19103022 9.854 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr1_+_143640664 9.106 ENSMUST00000038252.2
 B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chrX_-_143933204 8.958 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr2_+_124610278 8.452 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr10_-_109764840 7.903 ENSMUST00000163071.1
 Nav3
neuron navigator 3
chrX_-_143933089 7.834 ENSMUST00000087313.3
 Dcx
doublecortin
chr3_+_54156039 7.498 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr2_+_65620829 7.257 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr5_+_19227046 7.163 ENSMUST00000088516.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr2_-_45112890 6.933 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr5_+_19907502 6.734 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_+_19907774 6.551 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr18_-_22850738 6.233 ENSMUST00000092015.4
ENSMUST00000069215.6
 Nol4

nucleolar protein 4

chr13_-_51701041 6.213 ENSMUST00000110042.1
 Gm15440
predicted gene 15440
chr10_-_109010955 6.185 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr1_+_185454803 6.135 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 22.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
2.6 20.4 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.8 19.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 17.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.9 16.8 GO:0021860 pyramidal neuron development(GO:0021860)
1.2 11.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.3 10.7 GO:0005513 detection of calcium ion(GO:0005513)
0.1 9.9 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.7 9.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.3 8.6 GO:0097320 membrane tubulation(GO:0097320)
0.3 8.5 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 8.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.4 7.5 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
1.8 7.3 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
1.2 6.9 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 6.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.6 6.5 GO:0042447 hormone catabolic process(GO:0042447)
0.7 6.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.9 5.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3 5.5 GO:0071711 basement membrane organization(GO:0071711)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 50.2 GO:0045211 postsynaptic membrane(GO:0045211)
4.1 20.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 15.7 GO:0005874 microtubule(GO:0005874)
0.0 13.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.7 10.7 GO:0031045 dense core granule(GO:0031045)
0.0 9.9 GO:0005635 nuclear envelope(GO:0005635)
0.7 8.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 7.5 GO:0034704 calcium channel complex(GO:0034704)
0.5 7.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 6.5 GO:0005811 lipid particle(GO:0005811)
0.0 6.1 GO:0005667 transcription factor complex(GO:0005667)
0.4 6.0 GO:0042101 T cell receptor complex(GO:0042101)
0.8 5.9 GO:0071437 invadopodium(GO:0071437)
0.1 5.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 5.7 GO:0016324 apical plasma membrane(GO:0016324)
1.8 5.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 4.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 4.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.3 GO:0019866 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.1 3.9 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 24.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.9 22.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
3.4 20.4 GO:0070699 type II activin receptor binding(GO:0070699)
1.1 19.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 14.8 GO:0005057 receptor signaling protein activity(GO:0005057)
2.9 11.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.5 10.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
1.1 9.1 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 8.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 8.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 8.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 8.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.5 6.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.9 6.5 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 6.4 GO:0017124 SH3 domain binding(GO:0017124)
0.5 6.2 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 6.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 5.6 GO:0042805 actinin binding(GO:0042805)
0.0 5.6 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.4 5.5 GO:0051010 microtubule plus-end binding(GO:0051010)