Motif ID: Nr4a2

Z-value: 0.419


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.466.8e-05Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 3.709 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr18_+_86711059 2.597 ENSMUST00000068423.3
Cbln2
cerebellin 2 precursor protein
chr9_-_32344237 1.537 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr8_+_68880491 1.381 ENSMUST00000015712.8
Lpl
lipoprotein lipase
chr2_+_121295437 1.279 ENSMUST00000110639.1
Map1a
microtubule-associated protein 1 A
chr9_-_106656081 1.230 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr13_+_94875600 1.162 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr17_+_29360923 0.840 ENSMUST00000024810.6
Fgd2
FYVE, RhoGEF and PH domain containing 2
chr5_+_111581422 0.830 ENSMUST00000064930.3
C130026L21Rik
RIKEN cDNA C130026L21 gene
chr2_-_129699833 0.789 ENSMUST00000028883.5
Pdyn
prodynorphin
chr13_+_93304066 0.787 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr6_-_124814288 0.748 ENSMUST00000172132.2
Tpi1
triosephosphate isomerase 1
chr18_-_56975333 0.746 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr6_-_99096196 0.715 ENSMUST00000175886.1
Foxp1
forkhead box P1
chr4_-_36136463 0.693 ENSMUST00000098151.2
Lingo2
leucine rich repeat and Ig domain containing 2
chrX_+_150589907 0.688 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr10_+_110920170 0.687 ENSMUST00000020403.5
Csrp2
cysteine and glycine-rich protein 2
chr10_-_40302186 0.678 ENSMUST00000099945.4
Amd1
S-adenosylmethionine decarboxylase 1
chr2_+_4976113 0.643 ENSMUST00000167607.1
ENSMUST00000115010.2
Ucma

upper zone of growth plate and cartilage matrix associated

chr8_+_70863127 0.618 ENSMUST00000050921.2
A230052G05Rik
RIKEN cDNA A230052G05 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.5 GO:0010107 potassium ion import(GO:0010107)
0.3 1.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 1.4 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 1.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.4 1.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 1.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 1.2 GO:0014047 glutamate secretion(GO:0014047)
0.3 0.8 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 0.7 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.6 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.2 0.5 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 0.5 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 0.5 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.1 0.5 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.5 GO:0050832 defense response to fungus(GO:0050832)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0042627 chylomicron(GO:0042627)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.7 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.6 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 0.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.5 GO:0005518 collagen binding(GO:0005518)
0.2 1.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 1.2 GO:0019808 polyamine binding(GO:0019808)
0.2 1.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 0.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.7 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.7 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.2 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)