Motif ID: Nr6a1

Z-value: 0.486


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_389264540.123.3e-01Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_42245907 2.794 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr13_-_24761440 2.750 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr4_-_45530330 2.481 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr14_+_12189943 2.338 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr9_-_96437434 2.251 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr7_+_30314810 2.234 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr19_+_46707443 2.039 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr2_+_172472512 2.027 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr6_+_83349446 2.025 ENSMUST00000136501.1
 Bola3
bolA-like 3 (E. coli)
chr7_-_66427469 1.848 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr17_+_72918298 1.832 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr12_+_3807017 1.660 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr5_-_137610626 1.655 ENSMUST00000142675.1
 Pcolce
procollagen C-endopeptidase enhancer protein
chr5_-_30073554 1.422 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chr17_-_46645128 1.415 ENSMUST00000003642.6
 Klc4
kinesin light chain 4
chr12_+_3807076 1.407 ENSMUST00000174817.1
 Dnmt3a
DNA methyltransferase 3A
chr10_+_128083273 1.275 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr18_-_77767752 1.274 ENSMUST00000048192.7
 Haus1
HAUS augmin-like complex, subunit 1
chr15_-_98165613 1.236 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr5_-_5694024 1.135 ENSMUST00000115425.2
ENSMUST00000115427.1
ENSMUST00000115424.2
ENSMUST00000015797.4
 Steap2



six transmembrane epithelial antigen of prostate 2



chr8_+_75109528 1.121 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr9_+_50603892 1.110 ENSMUST00000044051.4
 Timm8b
translocase of inner mitochondrial membrane 8B
chr11_-_60811228 1.080 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr1_+_131970589 1.079 ENSMUST00000027695.6
 Slc45a3
solute carrier family 45, member 3
chr7_-_145283915 1.032 ENSMUST00000058022.4
 Tpcn2
two pore segment channel 2
chr1_+_151428612 0.969 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr5_-_137611429 0.952 ENSMUST00000031731.7
 Pcolce
procollagen C-endopeptidase enhancer protein
chr5_-_137611372 0.919 ENSMUST00000054564.6
 Pcolce
procollagen C-endopeptidase enhancer protein
chr11_+_6560183 0.915 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr12_-_115790884 0.880 ENSMUST00000081809.5
 Ighv1-73
immunoglobulin heavy variable 1-73
chr1_-_151428440 0.839 ENSMUST00000064771.5
 Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr14_+_58072686 0.805 ENSMUST00000022545.7
 Fgf9
fibroblast growth factor 9
chr17_+_26123514 0.782 ENSMUST00000025014.8
 Mrpl28
mitochondrial ribosomal protein L28
chr11_-_69822144 0.749 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr2_+_180071793 0.726 ENSMUST00000108901.1
 Mtg2
mitochondrial ribosome associated GTPase 2
chr9_+_73102398 0.679 ENSMUST00000174203.2
ENSMUST00000034737.6
ENSMUST00000173734.2
ENSMUST00000167514.1
 Gm20509
Khdc3


predicted gene 20509
KH domain containing 3, subcortical maternal complex member


chr10_-_80855187 0.655 ENSMUST00000035775.8
 Lsm7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr8_-_109693235 0.653 ENSMUST00000034164.4
 Ist1
increased sodium tolerance 1 homolog (yeast)
chr15_-_98165560 0.642 ENSMUST00000123922.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr5_-_5694559 0.642 ENSMUST00000115426.2
 Steap2
six transmembrane epithelial antigen of prostate 2
chr3_+_138526174 0.630 ENSMUST00000029803.7
 Eif4e
eukaryotic translation initiation factor 4E
chr4_+_123904832 0.615 ENSMUST00000030400.7
 Mycbp
c-myc binding protein
chr2_+_157424255 0.577 ENSMUST00000029175.7
ENSMUST00000092576.4
 Src

Rous sarcoma oncogene

chr15_-_73184840 0.576 ENSMUST00000044113.10
 Ago2
argonaute RISC catalytic subunit 2
chr9_-_50603792 0.572 ENSMUST00000000175.4
 Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
chr4_+_123904907 0.567 ENSMUST00000106202.3
 Mycbp
c-myc binding protein
chr9_-_121839460 0.564 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr7_-_105574324 0.537 ENSMUST00000081165.7
 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr10_-_43540945 0.532 ENSMUST00000147196.1
ENSMUST00000019932.3
 1700021F05Rik

RIKEN cDNA 1700021F05 gene

chr2_+_173737492 0.482 ENSMUST00000067530.4
 Vapb
vesicle-associated membrane protein, associated protein B and C
chr5_-_136986829 0.450 ENSMUST00000034953.7
ENSMUST00000085941.5
 Znhit1

zinc finger, HIT domain containing 1

chr11_+_120677226 0.426 ENSMUST00000129644.2
ENSMUST00000151160.1
 Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chr4_+_43632185 0.368 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr4_+_155562348 0.348 ENSMUST00000030939.7
 Nadk
NAD kinase
chr4_-_134552122 0.306 ENSMUST00000060435.6
 Sepn1
selenoprotein N, 1
chr6_+_48593927 0.292 ENSMUST00000135151.1
 Repin1
replication initiator 1
chr4_-_125065603 0.281 ENSMUST00000036383.3
 Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr7_+_128265675 0.246 ENSMUST00000118169.1
ENSMUST00000142841.1
 Slc5a2

solute carrier family 5 (sodium/glucose cotransporter), member 2

chr1_+_171329376 0.218 ENSMUST00000111299.1
ENSMUST00000064950.4
 Dedd

death effector domain-containing

chr4_-_123904826 0.195 ENSMUST00000181292.1
 Gm26606
predicted gene, 26606
chr12_-_71136611 0.182 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chr17_+_33629078 0.140 ENSMUST00000166627.1
ENSMUST00000073570.5
ENSMUST00000170225.1
 Zfp414


zinc finger protein 414


chr14_+_78849171 0.135 ENSMUST00000040990.5
 Vwa8
von Willebrand factor A domain containing 8
chr5_+_136987019 0.062 ENSMUST00000004968.4
 Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr15_+_100038635 0.050 ENSMUST00000100203.3
 Dip2b
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr7_-_130772652 0.017 ENSMUST00000057134.4
 Etos1
ectopic ossification 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.6 1.8 GO:0060166 olfactory pit development(GO:0060166)
0.6 1.8 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.4 2.8 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.4 3.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.4 1.1 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.3 1.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 2.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 0.7 GO:0009838 abscission(GO:0009838)
0.2 2.0 GO:0009404 toxin metabolic process(GO:0009404)
0.2 0.6 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.5 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 0.3 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1 0.6 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 0.8 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214)
0.1 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.9 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.1 0.5 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 2.3 GO:1901998 toxin transport(GO:1901998)
0.0 0.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.7 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 2.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 2.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.6 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 1.1 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.0 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 1.7 GO:1900046 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 0.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.7 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094)
0.0 0.7 GO:0030317 sperm motility(GO:0030317)
0.0 0.3 GO:0044381 glucose import in response to insulin stimulus(GO:0044381) regulation of glucose import in response to insulin stimulus(GO:2001273)
0.0 1.3 GO:0051225 spindle assembly(GO:0051225)
0.0 0.5 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.6 GO:0031122 cytoplasmic microtubule organization(GO:0031122)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 1.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 1.3 GO:0070652 HAUS complex(GO:0070652)
0.1 3.1 GO:0001741 XY body(GO:0001741)
0.1 0.7 GO:0045179 apical cortex(GO:0045179)
0.1 1.2 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 0.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.5 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:0090543 Flemming body(GO:0090543)
0.1 1.1 GO:0042555 MCM complex(GO:0042555)
0.1 1.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.0 5.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 4.2 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.4 3.1 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.4 1.8 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.4 1.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.4 1.1 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.3 1.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.6 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 1.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.8 GO:0015035 glutathione peroxidase activity(GO:0004602) protein disulfide oxidoreductase activity(GO:0015035)
0.1 1.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 2.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.3 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 1.4 GO:0005542 folic acid binding(GO:0005542)
0.1 3.5 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 3.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 3.0 GO:0030792 methylarsonite methyltransferase activity(GO:0030792)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.6 GO:0042169 insulin receptor binding(GO:0005158) SH2 domain binding(GO:0042169)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)