Motif ID: Nrf1

Z-value: 2.925


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.075.4e-01Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_88751649 10.241 ENSMUST00000041297.8
Zbed4
zinc finger, BED domain containing 4
chr9_+_59617284 7.862 ENSMUST00000026267.8
ENSMUST00000050483.7
Parp6

poly (ADP-ribose) polymerase family, member 6

chr10_+_79682304 7.850 ENSMUST00000166603.1
Cdc34
cell division cycle 34
chr9_+_21616230 7.770 ENSMUST00000174008.1
Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr2_+_157560078 7.526 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
Nnat







neuronatin







chr9_+_21616166 7.083 ENSMUST00000034707.8
ENSMUST00000098948.3
Smarca4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

chr14_+_59625281 6.994 ENSMUST00000053949.5
Shisa2
shisa homolog 2 (Xenopus laevis)
chr17_-_75551838 6.834 ENSMUST00000112507.3
Fam98a
family with sequence similarity 98, member A
chr11_+_73177236 6.670 ENSMUST00000108477.1
Tax1bp3
Tax1 (human T cell leukemia virus type I) binding protein 3
chrX_-_158043266 6.649 ENSMUST00000026750.8
ENSMUST00000112513.1
Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr11_+_50377719 6.420 ENSMUST00000069304.7
ENSMUST00000077817.7
Hnrnph1

heterogeneous nuclear ribonucleoprotein H1

chr11_+_73177083 6.278 ENSMUST00000040687.5
Tax1bp3
Tax1 (human T cell leukemia virus type I) binding protein 3
chr1_+_24005505 6.171 ENSMUST00000181961.1
Gm26524
predicted gene, 26524
chr7_-_29281977 6.157 ENSMUST00000098604.4
ENSMUST00000108236.3
Spint2

serine protease inhibitor, Kunitz type 2

chr1_-_54557595 6.069 ENSMUST00000097739.3
Pgap1
post-GPI attachment to proteins 1
chr7_-_137314394 6.026 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr16_+_90727490 5.984 ENSMUST00000181232.1
Gm17518
predicted gene, 17518
chr10_+_80295930 5.968 ENSMUST00000105359.1
Apc2
adenomatosis polyposis coli 2
chr10_+_79682169 5.871 ENSMUST00000020550.5
Cdc34
cell division cycle 34
chr1_-_24005608 5.861 ENSMUST00000027338.3
1110058L19Rik
RIKEN cDNA 1110058L19 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 620 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
3.7 14.9 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
1.9 13.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.5 13.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 12.9 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.5 12.8 GO:0007020 microtubule nucleation(GO:0007020)
0.2 11.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
1.0 10.9 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.5 10.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.5 9.9 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
3.2 9.5 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.1 9.3 GO:0006413 translational initiation(GO:0006413)
0.5 9.2 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
1.8 9.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.5 8.7 GO:0043968 histone H2A acetylation(GO:0043968)
2.1 8.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.4 7.9 GO:0045116 protein neddylation(GO:0045116)
1.9 7.7 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
1.9 7.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.3 7.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 285 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 18.2 GO:0005730 nucleolus(GO:0005730)
0.1 17.1 GO:0005874 microtubule(GO:0005874)
0.2 15.3 GO:0005814 centriole(GO:0005814)
0.4 13.6 GO:0090544 BAF-type complex(GO:0090544)
0.3 13.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 12.2 GO:0030027 lamellipodium(GO:0030027)
0.7 11.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
2.0 11.8 GO:0005726 perichromatin fibrils(GO:0005726)
0.3 11.6 GO:0016235 aggresome(GO:0016235)
1.0 10.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
3.6 10.8 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.7 10.2 GO:0032039 integrator complex(GO:0032039)
0.2 10.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.2 9.6 GO:0031415 NatA complex(GO:0031415)
0.1 9.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 9.2 GO:0005923 bicellular tight junction(GO:0005923)
0.2 9.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 9.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
2.1 8.5 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 376 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 64.9 GO:0044822 poly(A) RNA binding(GO:0044822)
0.1 35.5 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 22.6 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
1.9 21.3 GO:0030957 Tat protein binding(GO:0030957)
0.6 19.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 19.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 17.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 17.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 10.3 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
1.2 9.9 GO:0043208 glycosphingolipid binding(GO:0043208)
0.2 9.9 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.6 9.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 9.6 GO:0010340 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880) carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
3.2 9.5 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.3 9.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 9.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 9.2 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 9.2 GO:0008565 protein transporter activity(GO:0008565)
1.8 9.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.2 9.1 GO:0001540 beta-amyloid binding(GO:0001540)