Motif ID: Onecut1_Cux2

Z-value: 1.174

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.398.0e-04Click!
Cux2mm10_v2_chr5_-_122002340_1220023680.084.9e-01Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 25.787 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_102010138 19.563 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr14_+_68083853 15.730 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr12_+_55598917 11.898 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr19_-_57197377 9.072 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197496 8.790 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197435 8.644 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr1_-_158958367 7.524 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr19_-_57197556 7.360 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr9_-_50739365 7.136 ENSMUST00000117093.1
ENSMUST00000121634.1
 Dixdc1

DIX domain containing 1

chr12_+_72441933 6.690 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr1_+_165302625 6.252 ENSMUST00000111450.1
 Gpr161
G protein-coupled receptor 161
chrX_-_43274786 5.616 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chrX_+_134404780 5.143 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr3_+_8509477 4.915 ENSMUST00000029002.7
 Stmn2
stathmin-like 2
chrX_+_134404543 4.692 ENSMUST00000113228.1
ENSMUST00000153424.1
 Drp2

dystrophin related protein 2

chr18_-_72351029 4.615 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chr18_-_72351009 4.606 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr10_-_112928974 4.571 ENSMUST00000099276.2
 Atxn7l3b
ataxin 7-like 3B
chr12_+_72441852 4.536 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 32.8 GO:0030032 lamellipodium assembly(GO:0030032)
4.3 25.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 19.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
5.2 15.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.8 9.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.5 8.0 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.5 7.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.6 6.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.6 6.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 5.7 GO:0050808 synapse organization(GO:0050808)
0.3 5.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 5.6 GO:0060349 bone morphogenesis(GO:0060349)
1.6 4.9 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
1.4 4.3 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.2 3.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 3.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 3.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 3.2 GO:0071625 vocalization behavior(GO:0071625)
1.0 2.9 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 2.9 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 71.7 GO:0005634 nucleus(GO:0005634)
0.3 33.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 16.9 GO:0045211 postsynaptic membrane(GO:0045211)
5.2 15.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 9.9 GO:0005794 Golgi apparatus(GO:0005794)
0.8 9.2 GO:0032584 growth cone membrane(GO:0032584)
0.1 7.3 GO:0055037 recycling endosome(GO:0055037)
0.0 7.1 GO:0043679 axon terminus(GO:0043679)
0.2 4.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 4.0 GO:0000792 heterochromatin(GO:0000792)
0.0 3.9 GO:0030027 lamellipodium(GO:0030027)
0.1 3.6 GO:0043034 costamere(GO:0043034)
0.3 3.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.5 GO:0071564 npBAF complex(GO:0071564)
0.0 2.4 GO:0072562 blood microparticle(GO:0072562)
0.3 2.0 GO:0033269 internode region of axon(GO:0033269)
0.2 1.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.8 GO:0044308 axonal spine(GO:0044308)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 25.8 GO:0003779 actin binding(GO:0003779)
0.3 19.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 16.8 GO:0008270 zinc ion binding(GO:0008270)
0.7 15.7 GO:0043274 phospholipase binding(GO:0043274)
0.1 11.9 GO:0003714 transcription corepressor activity(GO:0003714)
1.5 9.2 GO:0005042 netrin receptor activity(GO:0005042)
1.2 8.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 8.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 8.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 7.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.9 6.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 5.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 4.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 4.9 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.4 4.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 3.6 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 2.9 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 2.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 2.7 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)