Motif ID: Onecut2_Onecut3

Z-value: 0.603

Transcription factors associated with Onecut2_Onecut3:

Gene SymbolEntrez IDGene Name
Onecut2 ENSMUSG00000045991.12 Onecut2
Onecut3 ENSMUSG00000045518.8 Onecut3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut3mm10_v2_chr10_+_80494835_804948730.311.0e-02Click!
Onecut2mm10_v2_chr18_+_64340225_64340364-0.084.9e-01Click!


Activity profile for motif Onecut2_Onecut3.

activity profile for motif Onecut2_Onecut3


Sorted Z-values histogram for motif Onecut2_Onecut3

Sorted Z-values for motif Onecut2_Onecut3



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 8.907 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_49636847 4.948 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_109545390 4.451 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr12_+_109544498 4.005 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr10_+_69533761 3.483 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr3_+_102010138 3.021 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr4_+_43384332 2.424 ENSMUST00000136360.1
 Rusc2
RUN and SH3 domain containing 2
chrY_+_897782 2.376 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr10_+_69533803 2.335 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
 Ank3


ankyrin 3, epithelial


chr6_-_127769427 1.873 ENSMUST00000032500.8
 Prmt8
protein arginine N-methyltransferase 8
chr10_-_45470201 1.718 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr7_-_34655500 1.543 ENSMUST00000032709.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr3_+_136670076 1.409 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_-_56895737 1.369 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr1_-_64121456 1.311 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr6_+_5390387 1.235 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr4_+_109343029 1.224 ENSMUST00000030281.5
 Eps15
epidermal growth factor receptor pathway substrate 15
chr10_+_69534208 1.208 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
 Ank3





ankyrin 3, epithelial





chr9_+_53771499 1.205 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr11_+_46235460 1.200 ENSMUST00000060185.2
 Fndc9
fibronectin type III domain containing 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 8.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 7.8 GO:0008340 determination of adult lifespan(GO:0008340)
0.7 7.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 4.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 3.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 2.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.5 2.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.6 1.9 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.5 1.9 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.2 1.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.4 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.2 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.3 1.0 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.2 1.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 0.9 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.7 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.7 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.2 0.6 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 1.9 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.3 1.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 0.5 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.4 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 7.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 3.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 2.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.4 1.9 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.3 1.9 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.0 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.9 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.7 GO:0031402 sodium ion binding(GO:0031402)
0.2 0.6 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 0.5 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.2 0.5 GO:0004140 dephospho-CoA kinase activity(GO:0004140)