Motif ID: Osr2_Osr1

Z-value: 0.840

Transcription factors associated with Osr2_Osr1:

Gene SymbolEntrez IDGene Name
Osr1 ENSMUSG00000048387.7 Osr1
Osr2 ENSMUSG00000022330.4 Osr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Osr1mm10_v2_chr12_+_9574437_95744480.191.1e-01Click!


Activity profile for motif Osr2_Osr1.

activity profile for motif Osr2_Osr1


Sorted Z-values histogram for motif Osr2_Osr1

Sorted Z-values for motif Osr2_Osr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Osr2_Osr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 178 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_109823585 7.407 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr2_-_80128834 7.055 ENSMUST00000102654.4
ENSMUST00000102655.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr4_+_13743424 6.740 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_126950687 5.915 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr4_-_134254076 5.416 ENSMUST00000060050.5
 Grrp1
glycine/arginine rich protein 1
chr15_-_43869993 5.338 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr3_-_89322883 5.189 ENSMUST00000029673.5
 Efna3
ephrin A3
chr7_-_57509995 5.123 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr5_+_107497762 4.983 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr5_+_107497718 4.907 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chrX_+_170010744 4.881 ENSMUST00000178789.1
 Gm21887
predicted gene, 21887
chr4_+_43383449 4.351 ENSMUST00000135216.1
ENSMUST00000152322.1
 Rusc2

RUN and SH3 domain containing 2

chr1_-_43163891 4.257 ENSMUST00000008280.7
 Fhl2
four and a half LIM domains 2
chr8_+_12984246 4.250 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chrY_+_90785442 4.142 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr2_+_136892168 3.863 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr7_-_123500449 3.476 ENSMUST00000042470.7
ENSMUST00000128217.1
 Zkscan2

zinc finger with KRAB and SCAN domains 2

chr9_-_16378231 3.253 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr3_-_127225847 3.158 ENSMUST00000182726.1
ENSMUST00000182779.1
 Ank2

ankyrin 2, brain

chr15_-_78718113 3.026 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 6.7 GO:0051101 regulation of DNA binding(GO:0051101)
0.8 6.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 6.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.2 5.9 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.6 5.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 5.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 5.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 4.3 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.6 4.2 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.9 3.5 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
1.1 3.3 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.1 3.3 GO:0010842 retina layer formation(GO:0010842)
0.0 3.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.9 2.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244) glutamate secretion, neurotransmission(GO:0061535)
0.0 2.5 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.5 2.3 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.2 2.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.3 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 2.2 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.1 GO:0036477 somatodendritic compartment(GO:0036477)
0.0 10.8 GO:0097708 cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708)
0.4 9.9 GO:0031430 M band(GO:0031430)
0.1 8.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 8.3 GO:0030027 lamellipodium(GO:0030027)
0.6 6.2 GO:0031931 TORC1 complex(GO:0031931)
0.3 5.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 3.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.5 GO:0072562 blood microparticle(GO:0072562)
0.0 3.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 3.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.0 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.4 2.6 GO:0071437 invadopodium(GO:0071437)
0.6 2.3 GO:1990032 parallel fiber(GO:1990032)
0.1 2.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.6 1.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.6 GO:0000145 exocyst(GO:0000145)
0.1 1.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 1.5 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0003714 transcription corepressor activity(GO:0003714)
1.0 7.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 6.1 GO:0050811 GABA receptor binding(GO:0050811)
0.2 5.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 5.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 5.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 4.6 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 4.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 4.3 GO:0070064 proline-rich region binding(GO:0070064)
0.3 4.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 4.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 3.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 3.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 3.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.3 3.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 2.8 GO:0034946 2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466)
0.4 2.4 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.3 2.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 2.3 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 2.2 GO:0050321 tau-protein kinase activity(GO:0050321)