Motif ID: Pax6

Z-value: 0.722


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105668888_105668914-0.761.8e-14Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 7.594 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_57118981 5.686 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr19_-_57118897 4.750 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr13_-_110280103 4.494 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr3_+_65109343 3.980 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr1_-_38836090 3.606 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr4_+_85205417 3.583 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr6_-_60829826 3.356 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr3_-_89245159 2.842 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr2_-_162661075 2.791 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr8_-_57962564 2.762 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr10_+_80356459 2.720 ENSMUST00000039836.8
ENSMUST00000105351.1
 Plk5

polo-like kinase 5

chr18_-_34373313 2.612 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr17_+_43016536 2.488 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr11_-_95587691 2.471 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr6_-_118780324 2.406 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
 Cacna1c



calcium channel, voltage-dependent, L type, alpha 1C subunit



chr5_-_18360384 2.404 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr7_-_12775658 2.404 ENSMUST00000046245.5
 Zscan18
zinc finger and SCAN domain containing 18
chr18_+_37447641 2.342 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr3_-_89245005 2.315 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 5.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 4.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.3 4.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 3.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.8 3.4 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.3 2.7 GO:0002347 response to tumor cell(GO:0002347)
0.8 2.5 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.8 2.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.6 2.4 GO:0098912 smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.2 2.4 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 1.7 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.2 1.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 1.3 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.3 1.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 1.2 GO:0006760 folic acid-containing compound metabolic process(GO:0006760)
0.3 1.1 GO:0061724 lipophagy(GO:0061724)
0.1 1.1 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 1.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.2 0.9 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.7 4.0 GO:1990635 proximal dendrite(GO:1990635)
0.8 3.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 2.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.7 GO:0031932 TORC2 complex(GO:0031932)
0.1 1.6 GO:0045095 keratin filament(GO:0045095)
0.3 1.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.0 GO:0070688 MLL5-L complex(GO:0070688)
0.1 0.9 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)
0.1 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.2 GO:0003779 actin binding(GO:0003779)
0.3 5.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.8 4.6 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 4.5 GO:0031489 myosin V binding(GO:0031489)
0.2 4.0 GO:0070402 NADPH binding(GO:0070402)
0.1 3.8 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 2.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.5 2.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 2.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 1.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.2 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.1 0.8 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 0.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.6 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.0 0.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)