Motif ID: Pbx1_Pbx3
Z-value: 1.438
Transcription factors associated with Pbx1_Pbx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pbx1 | ENSMUSG00000052534.9 | Pbx1 |
| Pbx3 | ENSMUSG00000038718.9 | Pbx3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pbx1 | mm10_v2_chr1_-_168431896_168431905 | -0.66 | 5.4e-10 | Click! |
| Pbx3 | mm10_v2_chr2_-_34372004_34372044 | 0.60 | 3.5e-08 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.1 | 33.2 | GO:0097402 | neuroblast migration(GO:0097402) |
| 8.0 | 23.9 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 7.2 | 21.6 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 5.7 | 45.9 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 5.4 | 21.5 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) |
| 4.6 | 22.8 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 4.1 | 12.3 | GO:0021557 | oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 3.7 | 14.8 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 3.3 | 13.3 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 3.0 | 3.0 | GO:0061074 | regulation of neural retina development(GO:0061074) |
| 2.9 | 14.5 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 2.3 | 6.9 | GO:0060023 | soft palate development(GO:0060023) |
| 2.2 | 11.0 | GO:0021764 | amygdala development(GO:0021764) |
| 2.2 | 6.5 | GO:0030862 | neuroblast division in subventricular zone(GO:0021849) regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862) |
| 2.0 | 5.9 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 1.9 | 11.2 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 1.8 | 5.5 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 1.7 | 5.2 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 1.6 | 9.9 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 1.6 | 4.9 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 1.6 | 4.7 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 1.5 | 6.2 | GO:1903898 | positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 1.5 | 4.5 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 1.4 | 4.2 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 1.4 | 32.9 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 1.3 | 3.8 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 1.2 | 3.7 | GO:1903998 | regulation of eating behavior(GO:1903998) |
| 1.2 | 6.1 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 1.2 | 18.8 | GO:0060736 | prostate gland growth(GO:0060736) |
| 1.2 | 19.6 | GO:0007530 | sex determination(GO:0007530) |
| 1.2 | 6.9 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 1.1 | 17.9 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 1.0 | 3.1 | GO:1903232 | melanosome assembly(GO:1903232) |
| 1.0 | 3.1 | GO:1903795 | regulation of inorganic anion transmembrane transport(GO:1903795) |
| 1.0 | 2.9 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.9 | 2.8 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 0.9 | 13.0 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.9 | 8.8 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.9 | 7.8 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.9 | 9.5 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.8 | 3.4 | GO:0016259 | selenocysteine metabolic process(GO:0016259) |
| 0.8 | 4.0 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.8 | 6.3 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.7 | 3.7 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.7 | 2.9 | GO:0035553 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.7 | 1.4 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.7 | 1.4 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.7 | 2.7 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.6 | 6.5 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.6 | 16.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.6 | 4.3 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.6 | 2.3 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.6 | 6.4 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.6 | 11.0 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.6 | 1.7 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.6 | 6.7 | GO:0046697 | decidualization(GO:0046697) |
| 0.6 | 10.0 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.5 | 7.6 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.5 | 5.4 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.5 | 2.2 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.5 | 3.8 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.5 | 5.5 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.5 | 5.0 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.4 | 4.0 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.4 | 1.3 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.4 | 1.2 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.4 | 1.2 | GO:0060672 | negative regulation of keratinocyte differentiation(GO:0045617) epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.4 | 3.3 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 0.4 | 6.4 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.4 | 0.4 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) |
| 0.4 | 1.8 | GO:1905049 | negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049) |
| 0.4 | 3.9 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.4 | 1.1 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.4 | 4.2 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.3 | 0.7 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.3 | 2.4 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216) |
| 0.3 | 3.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.3 | 6.7 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.3 | 1.3 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.3 | 2.2 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.3 | 0.6 | GO:0060681 | branch elongation involved in ureteric bud branching(GO:0060681) |
| 0.3 | 2.7 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.3 | 4.1 | GO:0006337 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
| 0.3 | 4.4 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.3 | 5.2 | GO:0046855 | phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) |
| 0.3 | 0.3 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.3 | 1.0 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.3 | 2.6 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.3 | 4.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.3 | 4.1 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.2 | 13.2 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.2 | 0.7 | GO:0070428 | granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) |
| 0.2 | 0.5 | GO:0071455 | cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455) |
| 0.2 | 2.8 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 0.2 | 1.2 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.2 | 2.4 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.2 | 2.2 | GO:0006573 | valine metabolic process(GO:0006573) |
| 0.2 | 1.2 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.2 | 1.5 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 1.1 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
| 0.2 | 1.3 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.2 | 5.0 | GO:0006739 | NADP metabolic process(GO:0006739) |
| 0.1 | 0.4 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.1 | 6.9 | GO:1904894 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
| 0.1 | 0.8 | GO:0000303 | response to superoxide(GO:0000303) |
| 0.1 | 5.3 | GO:0021884 | forebrain neuron development(GO:0021884) |
| 0.1 | 3.6 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.1 | 1.6 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 1.4 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 14.7 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.1 | 1.4 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
| 0.1 | 0.5 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.1 | 2.8 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 4.4 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.1 | 3.8 | GO:0006801 | superoxide metabolic process(GO:0006801) |
| 0.1 | 0.6 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 4.2 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 10.2 | GO:0001843 | neural tube closure(GO:0001843) |
| 0.1 | 18.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 4.5 | GO:0032330 | regulation of chondrocyte differentiation(GO:0032330) |
| 0.1 | 0.2 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 0.1 | 0.2 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.1 | 4.6 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.1 | 4.6 | GO:0001942 | hair follicle development(GO:0001942) molting cycle process(GO:0022404) hair cycle process(GO:0022405) |
| 0.1 | 0.8 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 3.3 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.1 | 0.3 | GO:0015677 | copper ion import(GO:0015677) |
| 0.1 | 1.3 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
| 0.1 | 1.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 0.4 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.1 | 1.6 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.2 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.0 | 0.8 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
| 0.0 | 1.6 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.0 | 1.1 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 4.6 | GO:0030218 | erythrocyte differentiation(GO:0030218) |
| 0.0 | 0.5 | GO:0032367 | intracellular cholesterol transport(GO:0032367) |
| 0.0 | 4.1 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 1.2 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.0 | 0.2 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.0 | 0.3 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.0 | 0.1 | GO:0097298 | regulation of nucleus size(GO:0097298) |
| 0.0 | 0.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.8 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.0 | 0.3 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.0 | 0.2 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 5.6 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.0 | 0.6 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.7 | GO:0000154 | rRNA modification(GO:0000154) |
| 0.0 | 5.8 | GO:0001654 | eye development(GO:0001654) |
| 0.0 | 0.2 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 0.0 | 0.8 | GO:0048661 | positive regulation of smooth muscle cell proliferation(GO:0048661) |
| 0.0 | 2.2 | GO:0001764 | neuron migration(GO:0001764) |
| 0.0 | 0.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 1.1 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 12.0 | GO:0055114 | oxidation-reduction process(GO:0055114) |
| 0.0 | 1.8 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.3 | GO:0035966 | response to topologically incorrect protein(GO:0035966) |
| 0.0 | 0.8 | GO:0009636 | response to toxic substance(GO:0009636) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 17.8 | GO:0000801 | central element(GO:0000801) |
| 5.1 | 45.9 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 4.3 | 38.9 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 4.3 | 21.6 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 2.6 | 13.0 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 2.0 | 5.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.9 | 9.7 | GO:0008623 | CHRAC(GO:0008623) |
| 1.5 | 9.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 1.2 | 11.0 | GO:0072687 | meiotic spindle(GO:0072687) |
| 1.1 | 5.3 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.8 | 3.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.8 | 4.0 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.6 | 3.7 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.6 | 23.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.6 | 2.8 | GO:1990357 | terminal web(GO:1990357) |
| 0.6 | 4.4 | GO:0016234 | inclusion body(GO:0016234) |
| 0.5 | 2.7 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.5 | 4.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.5 | 6.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.4 | 5.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.4 | 2.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.3 | 2.5 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.3 | 1.1 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.2 | 8.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.2 | 5.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 10.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 1.4 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.2 | 6.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.2 | 3.7 | GO:0045120 | pronucleus(GO:0045120) |
| 0.2 | 1.4 | GO:0043219 | lateral loop(GO:0043219) |
| 0.1 | 1.9 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 2.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 1.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 3.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.6 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 0.9 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 4.5 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 2.4 | GO:0000780 | condensed nuclear chromosome, centromeric region(GO:0000780) |
| 0.1 | 0.9 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.1 | 9.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 4.1 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.1 | 43.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 1.3 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 1.1 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.1 | 6.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 1.3 | GO:0001527 | microfibril(GO:0001527) |
| 0.1 | 6.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 8.8 | GO:0030496 | midbody(GO:0030496) |
| 0.1 | 3.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 0.3 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 1.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 1.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 11.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 3.6 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.1 | 4.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 11.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.3 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 1.5 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.1 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 10.5 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 2.4 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 1.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 4.1 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 1.9 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 0.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 20.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 1.2 | GO:0098803 | respiratory chain complex(GO:0098803) |
| 0.0 | 1.8 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 9.3 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 0.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.7 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.1 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 0.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 3.6 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.7 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 13.3 | GO:0035939 | microsatellite binding(GO:0035939) |
| 4.3 | 21.6 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 2.0 | 47.2 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 1.8 | 34.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 1.7 | 5.2 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 1.6 | 7.8 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 1.3 | 5.4 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
| 1.3 | 5.2 | GO:0042731 | PH domain binding(GO:0042731) |
| 1.3 | 6.4 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 1.2 | 13.2 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 1.1 | 17.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 1.0 | 3.1 | GO:0035651 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
| 1.0 | 4.2 | GO:0019808 | polyamine binding(GO:0019808) |
| 1.0 | 3.8 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.9 | 3.6 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.8 | 3.3 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.8 | 3.3 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.7 | 2.9 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.7 | 2.2 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.7 | 6.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.6 | 19.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.6 | 3.8 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.6 | 5.0 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.6 | 5.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.5 | 17.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.5 | 39.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.5 | 8.0 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.5 | 3.7 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.5 | 7.4 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.5 | 6.4 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.4 | 6.7 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.4 | 4.0 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.4 | 19.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.4 | 45.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.4 | 1.2 | GO:0004471 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) |
| 0.4 | 4.9 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.4 | 4.0 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.4 | 1.2 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
| 0.4 | 5.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.4 | 2.3 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.4 | 1.8 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.4 | 5.6 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.3 | 2.4 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.3 | 13.6 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693) |
| 0.3 | 10.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.3 | 5.5 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.3 | 3.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.3 | 6.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.3 | 4.4 | GO:0005536 | glucose binding(GO:0005536) |
| 0.3 | 2.4 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) mRNA CDS binding(GO:1990715) |
| 0.3 | 1.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.3 | 4.5 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.3 | 81.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.2 | 10.7 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.2 | 1.6 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 17.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.2 | 4.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 1.0 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.2 | 1.6 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.2 | 1.4 | GO:0001094 | RNA polymerase II basal transcription factor binding(GO:0001091) TFIID-class transcription factor binding(GO:0001094) |
| 0.2 | 7.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 1.2 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.2 | 1.1 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.2 | 5.4 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.2 | 2.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.2 | 2.3 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 3.8 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.9 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 5.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 1.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 4.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 3.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 0.4 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.1 | 2.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 5.0 | GO:0050661 | NADP binding(GO:0050661) |
| 0.1 | 1.6 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 3.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 0.3 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 0.1 | 2.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 6.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 2.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 2.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 0.6 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 0.2 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.1 | 0.9 | GO:0046933 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 0.8 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 1.2 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.1 | 0.2 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.1 | 2.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 2.3 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.1 | 2.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 0.4 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.1 | 0.2 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 7.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 1.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.6 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 1.2 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.6 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.8 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 2.9 | GO:0008186 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.0 | 0.2 | GO:0019841 | retinal binding(GO:0016918) retinol binding(GO:0019841) |
| 0.0 | 1.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.4 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.7 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 1.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.8 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.1 | GO:0004558 | alpha-1,4-glucosidase activity(GO:0004558) |
| 0.0 | 0.3 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.5 | GO:0015491 | cation:cation antiporter activity(GO:0015491) |
| 0.0 | 1.3 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 1.0 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.3 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.0 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.0 | 1.0 | GO:0005178 | integrin binding(GO:0005178) |
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