Motif ID: Pitx1
Z-value: 0.641
Transcription factors associated with Pitx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pitx1 | ENSMUSG00000021506.7 | Pitx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.2 | GO:0043696 | dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) |
| 1.3 | 6.6 | GO:0060447 | bud outgrowth involved in lung branching(GO:0060447) |
| 0.9 | 2.8 | GO:0072554 | blood vessel lumenization(GO:0072554) |
| 0.7 | 3.7 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.7 | 4.4 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.7 | 2.6 | GO:0003360 | brainstem development(GO:0003360) |
| 0.6 | 7.1 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.6 | 3.8 | GO:0003383 | apical constriction(GO:0003383) |
| 0.6 | 6.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.5 | 1.5 | GO:0097461 | ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) |
| 0.5 | 0.5 | GO:0060853 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101) |
| 0.5 | 2.8 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.4 | 5.1 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.4 | 2.5 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.4 | 1.4 | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway(GO:0070120) |
| 0.3 | 1.6 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 0.3 | 0.9 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
| 0.3 | 2.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.3 | 2.8 | GO:0003093 | regulation of glomerular filtration(GO:0003093) |
| 0.3 | 1.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.2 | 1.7 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.2 | 0.7 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.2 | 2.1 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
| 0.2 | 1.0 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.2 | 0.6 | GO:1904049 | regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.2 | 0.6 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.2 | 0.6 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.2 | 1.4 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 3.7 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.2 | 5.6 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.2 | 1.0 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.2 | 0.8 | GO:0032911 | nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.1 | 1.4 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 2.4 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.1 | 0.8 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 1.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.4 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
| 0.1 | 0.6 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) paramesonephric duct development(GO:0061205) |
| 0.1 | 3.7 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.1 | 2.6 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 2.9 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.1 | 1.2 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.1 | 2.6 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.1 | 0.4 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.1 | 0.4 | GO:0030242 | pexophagy(GO:0030242) |
| 0.1 | 1.7 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.1 | 0.3 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.1 | 0.4 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 0.5 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.1 | 0.2 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.1 | 0.1 | GO:0009642 | response to light intensity(GO:0009642) |
| 0.1 | 0.3 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.1 | 0.4 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.1 | 1.8 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042) |
| 0.1 | 0.2 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913) |
| 0.1 | 0.4 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.7 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.0 | 0.4 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.1 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.0 | 0.4 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.0 | 1.2 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.7 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.0 | 0.1 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.0 | 0.7 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
| 0.0 | 0.2 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.0 | 0.2 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.0 | 2.1 | GO:0045580 | regulation of T cell differentiation(GO:0045580) |
| 0.0 | 0.2 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.0 | 0.1 | GO:1904017 | positive regulation of female receptivity(GO:0045925) response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.0 | 0.1 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.0 | 0.2 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.0 | 0.0 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.0 | 0.3 | GO:0010955 | negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318) |
| 0.0 | 0.0 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.0 | 0.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.5 | GO:0035265 | organ growth(GO:0035265) |
| 0.0 | 0.0 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.0 | 0.3 | GO:0072673 | lamellipodium morphogenesis(GO:0072673) |
| 0.0 | 0.2 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
| 0.0 | 0.9 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.7 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.9 | 2.6 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 0.6 | 5.1 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.5 | 1.4 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.5 | 3.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.4 | 6.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.3 | 5.6 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.2 | 3.3 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.2 | 1.6 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.2 | 1.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.2 | 1.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 2.7 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.2 | 7.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 4.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 0.5 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 0.6 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.1 | 1.7 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.7 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.1 | 2.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 1.4 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 2.2 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 1.6 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 0.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 2.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.6 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.7 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 2.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.0 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.4 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.0 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 0.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 4.9 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 1.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 2.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.6 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 1.1 | 3.3 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 1.1 | 6.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 1.1 | 4.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.0 | 6.8 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.9 | 3.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.6 | 2.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.5 | 1.0 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.5 | 1.5 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.4 | 2.6 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.4 | 1.7 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.4 | 3.7 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.4 | 5.2 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.4 | 3.7 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.3 | 2.5 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.3 | 7.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 0.9 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.2 | 0.9 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.2 | 1.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 2.8 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 7.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 2.6 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 0.4 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.1 | 0.4 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.1 | 2.7 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 3.2 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 1.4 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 2.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 0.8 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 4.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 1.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 2.4 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 0.8 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 0.6 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 4.8 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 0.3 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.1 | 1.6 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.5 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.0 | 0.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.8 | GO:0008179 | adenylate cyclase binding(GO:0008179) receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 1.4 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.0 | 1.3 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693) |
| 0.0 | 2.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.2 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.0 | 1.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.3 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.6 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.0 | 0.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 3.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.0 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.2 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.0 | 2.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.4 | GO:0034930 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131) |
| 0.0 | 2.5 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.2 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.6 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.2 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.4 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
