Motif ID: Pitx2_Otx2

Z-value: 1.614

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx2mm10_v2_chr14_-_48662740_486628720.709.9e-12Click!
Pitx2mm10_v2_chr3_+_129199878_1291999130.667.3e-10Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_75782080 27.025 ENSMUST00000181224.1
AU020206
expressed sequence AU020206
chr6_-_88898664 22.021 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr2_+_164562579 19.750 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr11_-_106998483 18.911 ENSMUST00000124541.1
Kpna2
karyopherin (importin) alpha 2
chr9_-_70421533 15.184 ENSMUST00000034742.6
Ccnb2
cyclin B2
chr6_+_34354119 14.895 ENSMUST00000038406.6
Akr1b8
aldo-keto reductase family 1, member B8
chr9_+_119357381 14.734 ENSMUST00000039610.8
Xylb
xylulokinase homolog (H. influenzae)
chr4_-_117182623 14.328 ENSMUST00000065896.2
Kif2c
kinesin family member 2C
chr17_+_35861318 13.649 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr17_+_87635974 12.736 ENSMUST00000053577.8
Epcam
epithelial cell adhesion molecule
chr11_-_60811228 12.016 ENSMUST00000018744.8
Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr14_-_20181773 11.961 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr14_-_47411666 11.342 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr10_-_77089428 11.221 ENSMUST00000156009.1
Col18a1
collagen, type XVIII, alpha 1
chr18_+_34751803 11.203 ENSMUST00000181453.1
ENSMUST00000181641.1
2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr11_+_97029925 10.918 ENSMUST00000021249.4
Scrn2
secernin 2
chr16_+_30065333 10.834 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr10_-_128180265 10.722 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr17_+_35861343 10.345 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr1_+_135232045 10.241 ENSMUST00000110798.3
Gm4204
predicted gene 4204

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 405 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 32.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 22.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.7 22.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 19.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
5.7 17.1 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
5.6 16.8 GO:0042732 D-xylose metabolic process(GO:0042732)
5.0 14.9 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
2.9 14.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 14.1 GO:0031109 microtubule polymerization or depolymerization(GO:0031109)
0.3 13.9 GO:0048538 thymus development(GO:0048538)
2.8 13.8 GO:0015705 iodide transport(GO:0015705)
0.4 13.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
3.2 12.7 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.2 12.5 GO:0006012 galactose metabolic process(GO:0006012)
4.0 12.0 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
1.2 12.0 GO:0030322 stabilization of membrane potential(GO:0030322)
1.4 11.6 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
3.6 10.8 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.2 10.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.7 10.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 65.0 GO:0070062 extracellular exosome(GO:0070062)
0.6 43.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 40.8 GO:0005643 nuclear pore(GO:0005643)
0.7 32.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
3.3 26.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
1.5 24.8 GO:0005652 nuclear lamina(GO:0005652)
1.3 21.1 GO:0031616 spindle pole centrosome(GO:0031616)
2.3 16.3 GO:0001940 male pronucleus(GO:0001940)
0.3 16.1 GO:0005871 kinesin complex(GO:0005871)
0.1 15.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 15.0 GO:0005581 collagen trimer(GO:0005581)
0.1 14.1 GO:0005903 brush border(GO:0005903)
0.3 13.8 GO:0034707 chloride channel complex(GO:0034707)
0.2 13.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 12.6 GO:0005840 ribosome(GO:0005840)
0.5 12.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 12.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 12.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 11.9 GO:0005667 transcription factor complex(GO:0005667)
1.4 11.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 294 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 65.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 52.0 GO:0044822 poly(A) RNA binding(GO:0044822)
0.7 32.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.1 31.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
2.8 22.0 GO:0003688 DNA replication origin binding(GO:0003688)
5.7 17.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 17.0 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.1 15.7 GO:0005198 structural molecule activity(GO:0005198)
1.2 15.3 GO:0008301 DNA binding, bending(GO:0008301)
2.5 14.9 GO:0001758 retinal dehydrogenase activity(GO:0001758)
3.5 13.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
4.6 13.7 GO:0070905 serine binding(GO:0070905)
0.3 13.3 GO:0016504 peptidase activator activity(GO:0016504)
0.9 13.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 12.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
1.6 12.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.9 12.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
1.1 12.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.1 11.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
1.1 11.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)