Motif ID: Pitx2_Otx2
Z-value: 1.614


Transcription factors associated with Pitx2_Otx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Otx2 | ENSMUSG00000021848.9 | Otx2 |
Pitx2 | ENSMUSG00000028023.10 | Pitx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Otx2 | mm10_v2_chr14_-_48662740_48662872 | 0.70 | 9.9e-12 | Click! |
Pitx2 | mm10_v2_chr3_+_129199878_129199913 | 0.66 | 7.3e-10 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 405 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 32.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.2 | 22.8 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
1.7 | 22.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.7 | 19.2 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
5.7 | 17.1 | GO:0015938 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) |
5.6 | 16.8 | GO:0042732 | D-xylose metabolic process(GO:0042732) |
5.0 | 14.9 | GO:0016095 | polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310) |
2.9 | 14.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.1 | 14.1 | GO:0031109 | microtubule polymerization or depolymerization(GO:0031109) |
0.3 | 13.9 | GO:0048538 | thymus development(GO:0048538) |
2.8 | 13.8 | GO:0015705 | iodide transport(GO:0015705) |
0.4 | 13.6 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
3.2 | 12.7 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
1.2 | 12.5 | GO:0006012 | galactose metabolic process(GO:0006012) |
4.0 | 12.0 | GO:0009177 | deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) |
1.2 | 12.0 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
1.4 | 11.6 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
3.6 | 10.8 | GO:0021557 | oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
0.2 | 10.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
0.7 | 10.4 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 215 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 65.0 | GO:0070062 | extracellular exosome(GO:0070062) |
0.6 | 43.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.5 | 40.8 | GO:0005643 | nuclear pore(GO:0005643) |
0.7 | 32.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
3.3 | 26.7 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
1.5 | 24.8 | GO:0005652 | nuclear lamina(GO:0005652) |
1.3 | 21.1 | GO:0031616 | spindle pole centrosome(GO:0031616) |
2.3 | 16.3 | GO:0001940 | male pronucleus(GO:0001940) |
0.3 | 16.1 | GO:0005871 | kinesin complex(GO:0005871) |
0.1 | 15.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.2 | 15.0 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 14.1 | GO:0005903 | brush border(GO:0005903) |
0.3 | 13.8 | GO:0034707 | chloride channel complex(GO:0034707) |
0.2 | 13.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
0.1 | 12.6 | GO:0005840 | ribosome(GO:0005840) |
0.5 | 12.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.3 | 12.3 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 12.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 11.9 | GO:0005667 | transcription factor complex(GO:0005667) |
1.4 | 11.6 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 294 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 65.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.1 | 52.0 | GO:0044822 | poly(A) RNA binding(GO:0044822) |
0.7 | 32.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
1.1 | 31.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
2.8 | 22.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
5.7 | 17.1 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
0.0 | 17.0 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
0.1 | 15.7 | GO:0005198 | structural molecule activity(GO:0005198) |
1.2 | 15.3 | GO:0008301 | DNA binding, bending(GO:0008301) |
2.5 | 14.9 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
3.5 | 13.8 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
4.6 | 13.7 | GO:0070905 | serine binding(GO:0070905) |
0.3 | 13.3 | GO:0016504 | peptidase activator activity(GO:0016504) |
0.9 | 13.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.1 | 12.9 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
1.6 | 12.7 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
0.9 | 12.6 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
1.1 | 12.0 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
1.1 | 11.6 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
1.1 | 11.6 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |