Motif ID: Pitx3

Z-value: 0.741


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_62899118 3.868 ENSMUST00000174189.1
Tet1
tet methylcytosine dioxygenase 1
chr18_+_64254359 3.380 ENSMUST00000025477.7
St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr8_+_65967157 2.724 ENSMUST00000072482.6
March1
membrane-associated ring finger (C3HC4) 1
chr7_+_18987518 2.472 ENSMUST00000063563.7
Nanos2
nanos homolog 2 (Drosophila)
chr17_-_32800938 2.263 ENSMUST00000080905.6
Zfp811
zinc finger protein 811
chr10_-_53379816 2.224 ENSMUST00000095691.5
Cep85l
centrosomal protein 85-like
chr10_+_81718919 2.097 ENSMUST00000085664.5
Zfp433
RIKEN cDNA 1700123A16 gene
chr9_-_22307638 2.087 ENSMUST00000086278.6
Zfp810
zinc finger protein 810
chr16_+_17276291 2.058 ENSMUST00000164950.1
ENSMUST00000159242.1
Tmem191c

transmembrane protein 191C

chrX_+_7909542 2.032 ENSMUST00000086274.2
Gm10490
predicted gene 10490
chr13_-_67609617 1.950 ENSMUST00000138725.1
AA987161
expressed sequence AA987161
chr5_+_90759299 1.949 ENSMUST00000031318.4
Cxcl5
chemokine (C-X-C motif) ligand 5
chr7_-_45370559 1.917 ENSMUST00000003971.7
Lin7b
lin-7 homolog B (C. elegans)
chr15_+_80287234 1.906 ENSMUST00000160424.1
Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr8_+_69300776 1.871 ENSMUST00000078257.6
D130040H23Rik
RIKEN cDNA D130040H23 gene
chr9_+_118506226 1.802 ENSMUST00000084820.4
Golga4
golgi autoantigen, golgin subfamily a, 4
chr11_-_79296906 1.759 ENSMUST00000068448.2
Gm9964
predicted gene 9964
chr2_-_132578244 1.757 ENSMUST00000110142.1
Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr13_-_77131276 1.740 ENSMUST00000159300.1
Ankrd32
ankyrin repeat domain 32
chr15_+_76879232 1.719 ENSMUST00000023179.5
Zfp7
zinc finger protein 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 3.9 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.8 3.4 GO:1990743 protein sialylation(GO:1990743)
0.0 2.7 GO:0001824 blastocyst development(GO:0001824)
0.5 2.5 GO:0044838 cell quiescence(GO:0044838)
0.1 2.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.6 2.3 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.7 2.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 2.1 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.4 2.0 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1 2.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.6 1.9 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.4 1.9 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 1.9 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 1.8 GO:0000042 protein targeting to Golgi(GO:0000042)
0.3 1.7 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 1.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 1.6 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.5 1.5 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.4 1.5 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 2.3 GO:0000802 transverse filament(GO:0000802)
0.1 1.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.5 1.5 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.3 1.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)
0.1 1.3 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.3 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.2 GO:0072686 mitotic spindle(GO:0072686)
0.3 1.1 GO:0031230 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.1 1.1 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 1.0 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.9 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.6 3.9 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 3.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.6 3.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 3.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.7 GO:0042287 MHC protein binding(GO:0042287)
0.0 2.7 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 2.5 GO:0030246 carbohydrate binding(GO:0030246)
0.2 2.4 GO:0031005 filamin binding(GO:0031005)
0.0 2.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 2.1 GO:0030275 LRR domain binding(GO:0030275)
0.4 2.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.5 1.9 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.2 1.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.9 GO:0003729 mRNA binding(GO:0003729)
0.2 1.8 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 1.8 GO:0002020 protease binding(GO:0002020)
0.0 1.7 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.1 1.5 GO:0017049 GTP-Rho binding(GO:0017049)