Motif ID: Pknox2_Pknox1
Z-value: 0.918
Transcription factors associated with Pknox2_Pknox1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pknox1 | ENSMUSG00000006705.6 | Pknox1 |
| Pknox2 | ENSMUSG00000035934.9 | Pknox2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pknox1 | mm10_v2_chr17_+_31564749_31564854 | 0.42 | 3.0e-04 | Click! |
| Pknox2 | mm10_v2_chr9_-_37147257_37147323 | 0.38 | 1.0e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 7.5 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 1.4 | 9.8 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 1.3 | 6.5 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) |
| 1.2 | 3.5 | GO:1901228 | regulation of osteoclast proliferation(GO:0090289) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 1.0 | 9.8 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.7 | 4.2 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.6 | 1.8 | GO:0030070 | insulin processing(GO:0030070) |
| 0.6 | 4.1 | GO:0072539 | T-helper 17 cell differentiation(GO:0072539) |
| 0.4 | 2.9 | GO:1905206 | positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206) |
| 0.4 | 2.3 | GO:0035743 | CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745) |
| 0.4 | 2.5 | GO:0019254 | carnitine metabolic process, CoA-linked(GO:0019254) |
| 0.3 | 2.0 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.3 | 3.9 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.2 | 0.7 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.2 | 3.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.2 | 3.0 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 0.7 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.2 | 0.5 | GO:0090071 | negative regulation of ribosome biogenesis(GO:0090071) |
| 0.2 | 1.8 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
| 0.2 | 1.6 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 1.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.1 | 0.7 | GO:2000325 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 0.1 | 1.3 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.1 | 0.6 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
| 0.1 | 2.2 | GO:0007530 | sex determination(GO:0007530) |
| 0.1 | 1.3 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.1 | 1.0 | GO:0097070 | ductus arteriosus closure(GO:0097070) |
| 0.1 | 4.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 2.7 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 1.4 | GO:0061029 | eyelid development in camera-type eye(GO:0061029) |
| 0.1 | 0.2 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 0.4 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 1.4 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.0 | 2.7 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 3.2 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 4.7 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 0.2 | GO:0031652 | positive regulation of heat generation(GO:0031652) |
| 0.0 | 1.8 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.2 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.0 | 3.4 | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) |
| 0.0 | 2.0 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 1.0 | GO:0071158 | positive regulation of cell cycle arrest(GO:0071158) |
| 0.0 | 0.2 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.0 | 0.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 3.0 | GO:0048814 | regulation of dendrite morphogenesis(GO:0048814) |
| 0.0 | 0.2 | GO:2000252 | negative regulation of feeding behavior(GO:2000252) |
| 0.0 | 0.8 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 0.0 | 0.8 | GO:0007099 | centriole replication(GO:0007099) |
| 0.0 | 3.3 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.0 | 7.3 | GO:0045666 | positive regulation of neuron differentiation(GO:0045666) |
| 0.0 | 0.6 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.1 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.9 | GO:0071953 | elastic fiber(GO:0071953) |
| 1.3 | 4.0 | GO:0000801 | central element(GO:0000801) |
| 0.4 | 9.8 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.3 | 3.1 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.2 | 2.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 1.8 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 3.0 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 1.4 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 0.8 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 5.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.4 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 0.5 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 0.4 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 3.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.7 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 6.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 13.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 5.0 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 5.7 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 2.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 6.9 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 0.2 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 9.8 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 1.0 | 4.2 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 1.0 | 4.1 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.6 | 3.9 | GO:0070728 | leucine binding(GO:0070728) |
| 0.6 | 2.5 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) |
| 0.6 | 6.5 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.4 | 3.5 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.3 | 1.0 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
| 0.2 | 3.3 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 1.3 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.2 | 1.8 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) cobalt ion binding(GO:0050897) |
| 0.1 | 9.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 4.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 4.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.8 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 7.3 | GO:0020037 | heme binding(GO:0020037) |
| 0.1 | 0.5 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.1 | 1.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 2.9 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.1 | 2.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 2.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 1.5 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 0.7 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 1.3 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 2.0 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 10.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 0.2 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 2.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 1.2 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.4 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 2.0 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 16.7 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 0.3 | GO:0005536 | glucose binding(GO:0005536) |
| 0.0 | 2.3 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.8 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 2.0 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.4 | GO:0008026 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
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