Motif ID: Plag1

Z-value: 0.517


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_3938401-0.161.8e-01Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_133498538 3.705 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr4_-_129121699 3.193 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr11_+_77930800 2.725 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr15_-_78544345 2.630 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr5_+_117841839 2.192 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr13_-_14523178 2.186 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr19_-_5457397 2.060 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr10_+_58813359 2.057 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr4_-_129121889 2.007 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr16_-_18622403 1.985 ENSMUST00000167388.1
 Gp1bb
glycoprotein Ib, beta polypeptide
chr7_-_79386943 1.898 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr3_+_89520152 1.851 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr4_-_129121234 1.829 ENSMUST00000030572.3
 Hpca
hippocalcin
chr5_+_117781017 1.757 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr3_-_88000350 1.658 ENSMUST00000090971.5
 Bcan
brevican
chr7_-_46099752 1.612 ENSMUST00000180081.1
 Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
chrX_+_166344692 1.513 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr9_+_40269202 1.464 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr6_-_48841373 1.458 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr7_-_27446599 1.428 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 7.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 6.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 5.9 GO:0021696 cerebellar cortex morphogenesis(GO:0021696)
0.6 4.0 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 4.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
1.0 3.9 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.5 3.5 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 3.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 3.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 2.8 GO:0010107 potassium ion import(GO:0010107)
0.1 2.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 2.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 2.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 2.1 GO:0006813 potassium ion transport(GO:0006813)
0.4 2.0 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.2 2.0 GO:0032482 Rab protein signal transduction(GO:0032482)
0.4 1.9 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.3 1.9 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 1.9 GO:0033344 cholesterol efflux(GO:0033344)
0.1 1.8 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 5.8 GO:0044297 cell body(GO:0044297)
0.1 4.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.8 4.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 4.0 GO:0097060 synaptic membrane(GO:0097060)
0.3 3.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 3.1 GO:0097440 apical dendrite(GO:0097440)
0.2 2.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.4 GO:0034704 calcium channel complex(GO:0034704)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.3 GO:0032590 dendrite membrane(GO:0032590)
0.4 2.2 GO:0008091 spectrin(GO:0008091)
0.2 2.2 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.0 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.6 1.9 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 1.9 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.3 3.9 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 2.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.9 2.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 2.4 GO:0030507 spectrin binding(GO:0030507)
0.0 2.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.5 2.0 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 2.0 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.2 2.0 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.1 2.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.5 1.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 1.9 GO:0005131 growth hormone receptor binding(GO:0005131)
0.2 1.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.8 GO:0005267 potassium channel activity(GO:0005267)
0.6 1.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 1.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.6 GO:0031749 D2 dopamine receptor binding(GO:0031749)