Motif ID: Plagl1

Z-value: 0.553


Transcription factors associated with Plagl1:

Gene SymbolEntrez IDGene Name
Plagl1 ENSMUSG00000019817.12 Plagl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.651.1e-09Click!


Activity profile for motif Plagl1.

activity profile for motif Plagl1


Sorted Z-values histogram for motif Plagl1

Sorted Z-values for motif Plagl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plagl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 125 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_91807424 5.466 ENSMUST00000162300.1
 Grip2
glutamate receptor interacting protein 2
chr6_-_91807318 4.858 ENSMUST00000159684.1
 Grip2
glutamate receptor interacting protein 2
chr2_-_104257400 4.720 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr17_+_46297406 4.530 ENSMUST00000061722.6
ENSMUST00000166280.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr4_+_152338619 3.764 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr10_-_81482655 3.289 ENSMUST00000120508.1
ENSMUST00000118763.1
 Celf5

CUGBP, Elav-like family member 5

chr4_+_47288057 3.204 ENSMUST00000140413.1
ENSMUST00000107731.2
 Col15a1

collagen, type XV, alpha 1

chr17_+_46297917 3.022 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr17_-_24644933 2.874 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr3_+_26331150 2.688 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr5_-_139130159 2.672 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_+_101496648 2.411 ENSMUST00000106930.1
ENSMUST00000154120.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr19_+_4711153 2.270 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr18_+_32377176 2.246 ENSMUST00000091967.5
ENSMUST00000025239.7
 Bin1

bridging integrator 1

chr11_+_98741871 2.231 ENSMUST00000103139.4
 Thra
thyroid hormone receptor alpha
chr4_+_47288287 2.078 ENSMUST00000146967.1
 Col15a1
collagen, type XV, alpha 1
chr6_+_4504814 2.054 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr19_+_6497772 2.011 ENSMUST00000113458.1
ENSMUST00000113459.1
 Nrxn2

neurexin II

chr11_+_98741805 1.944 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr11_-_120047144 1.927 ENSMUST00000103020.1
 Aatk
apoptosis-associated tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 10.3 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.2 7.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 4.7 GO:0098792 xenophagy(GO:0098792)
1.4 4.2 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.1 3.9 GO:0071625 vocalization behavior(GO:0071625)
0.8 3.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 3.3 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 2.8 GO:0051028 mRNA transport(GO:0051028)
0.2 2.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 2.4 GO:0046684 response to pyrethroid(GO:0046684)
0.4 2.4 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 2.3 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.1 2.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 2.3 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.2 2.2 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.2 2.1 GO:0043589 skin morphogenesis(GO:0043589)
0.5 1.9 GO:0046898 response to cycloheximide(GO:0046898)
0.4 1.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 1.9 GO:0032482 Rab protein signal transduction(GO:0032482)
0.2 1.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.3 GO:0043198 dendritic shaft(GO:0043198)
0.1 5.9 GO:0005581 collagen trimer(GO:0005581)
0.2 4.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 3.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 2.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.7 GO:0032420 stereocilium(GO:0032420)
0.1 2.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.4 2.3 GO:0008091 spectrin(GO:0008091)
0.0 2.2 GO:0044295 axonal growth cone(GO:0044295)
0.7 2.1 GO:0005584 collagen type I trimer(GO:0005584)
0.0 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.3 1.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 1.9 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.5 GO:0030426 growth cone(GO:0030426)
0.1 1.4 GO:0005869 dynactin complex(GO:0005869)
0.1 1.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 7.6 GO:0005198 structural molecule activity(GO:0005198)
0.0 5.0 GO:0005509 calcium ion binding(GO:0005509)
1.4 4.2 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.1 3.8 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 2.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 2.5 GO:0048156 tau protein binding(GO:0048156)
0.1 2.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.5 2.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 2.3 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.1 2.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 2.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.6 1.9 GO:0070905 serine binding(GO:0070905)
0.2 1.9 GO:0051434 BH3 domain binding(GO:0051434)
0.0 1.9 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.2 1.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 1.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.4 1.5 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)