Motif ID: Pou4f1_Pou6f1

Z-value: 0.734

Transcription factors associated with Pou4f1_Pou6f1:

Gene SymbolEntrez IDGene Name
Pou4f1 ENSMUSG00000048349.8 Pou4f1
Pou6f1 ENSMUSG00000009739.10 Pou6f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou6f1mm10_v2_chr15_-_100599983_1006000390.681.2e-10Click!
Pou4f1mm10_v2_chr14_-_104467984_104468041-0.432.3e-04Click!


Activity profile for motif Pou4f1_Pou6f1.

activity profile for motif Pou4f1_Pou6f1


Sorted Z-values histogram for motif Pou4f1_Pou6f1

Sorted Z-values for motif Pou4f1_Pou6f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou4f1_Pou6f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_42681513 7.570 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr9_-_58202281 6.485 ENSMUST00000163897.1
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr9_-_58201705 5.756 ENSMUST00000163200.1
ENSMUST00000165276.1
 Islr2

immunoglobulin superfamily containing leucine-rich repeat 2

chr14_-_30353468 5.345 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr9_+_113812547 5.109 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr15_+_92161343 5.070 ENSMUST00000068378.5
 Cntn1
contactin 1
chr1_-_56978534 5.030 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr15_-_100599983 4.986 ENSMUST00000073837.6
 Pou6f1
POU domain, class 6, transcription factor 1
chr8_+_12984246 4.956 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chr4_+_152338619 4.835 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr15_-_100599864 4.826 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr18_+_37504264 4.807 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr11_+_98348404 4.781 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr1_-_176807124 3.865 ENSMUST00000057037.7
 Cep170
centrosomal protein 170
chr15_+_18818895 3.677 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr1_-_60043087 3.447 ENSMUST00000027172.6
 Ica1l
islet cell autoantigen 1-like
chr2_+_68104671 3.413 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr6_+_80018877 3.329 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4



chr3_+_26331150 3.192 ENSMUST00000099182.2
 A830092H15Rik
RIKEN cDNA A830092H15 gene
chr9_-_40346290 3.058 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 9.2 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.7 8.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 7.2 GO:0007097 nuclear migration(GO:0007097)
0.4 6.2 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.4 5.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 5.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
1.8 5.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.9 5.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 5.1 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.2 5.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
1.6 4.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
1.0 4.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.4 4.5 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
1.1 4.3 GO:0009414 response to water deprivation(GO:0009414)
0.3 4.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 3.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 3.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.0 2.9 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.3 2.9 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 11.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.3 8.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 6.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 6.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 6.0 GO:0031225 anchored component of membrane(GO:0031225)
0.5 5.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.7 5.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 5.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 4.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 4.3 GO:0042641 actomyosin(GO:0042641)
0.0 4.2 GO:0055037 recycling endosome(GO:0055037)
0.0 3.9 GO:0005814 centriole(GO:0005814)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 2.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 2.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.6 GO:0016607 nuclear speck(GO:0016607)
0.0 2.6 GO:0030424 axon(GO:0030424)
0.1 2.5 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.4 7.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.2 6.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 5.8 GO:0017124 SH3 domain binding(GO:0017124)
0.4 5.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.9 5.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 5.1 GO:0001948 glycoprotein binding(GO:0001948)
0.3 5.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 4.9 GO:0000287 magnesium ion binding(GO:0000287)
1.6 4.8 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1 4.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 4.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 4.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 3.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.4 3.4 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 3.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 2.9 GO:0003680 AT DNA binding(GO:0003680)
0.7 2.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 2.7 GO:0008017 microtubule binding(GO:0008017)
0.5 2.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)