Motif ID: Pou6f2_Pou4f2

Z-value: 0.738

Transcription factors associated with Pou6f2_Pou4f2:

Gene SymbolEntrez IDGene Name
Pou4f2 ENSMUSG00000031688.3 Pou4f2
Pou6f2 ENSMUSG00000009734.11 Pou6f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou4f2mm10_v2_chr8_-_78436640_784366490.405.4e-04Click!
Pou6f2mm10_v2_chr13_-_18382041_18382041-0.075.5e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_56296551 11.629 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr18_-_31949571 7.718 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr10_+_99263224 6.169 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr6_+_63255971 6.114 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr1_+_153665666 5.910 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr13_-_81570640 5.613 ENSMUST00000109565.2
Gpr98
G protein-coupled receptor 98
chr1_+_153665274 5.474 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr1_-_72874877 5.292 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr12_-_56535047 5.068 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr4_-_58499398 5.003 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr14_+_27039001 4.808 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr2_+_109917639 4.700 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr7_-_49636847 4.143 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr1_+_153665587 4.126 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr1_+_153665627 4.030 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr6_+_88724828 3.706 ENSMUST00000089449.2
Mgll
monoglyceride lipase
chr2_+_71528657 3.560 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr17_-_49564262 3.331 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr4_+_117849361 3.055 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_+_172341197 3.021 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr6_+_88724667 2.984 ENSMUST00000163271.1
Mgll
monoglyceride lipase
chr4_+_117849193 2.938 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr3_+_68572245 2.856 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr5_-_62765618 2.689 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_138422898 2.678 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chr19_+_3323301 2.589 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr2_-_168767029 2.575 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr12_+_38781093 2.434 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr12_+_38780284 2.387 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr8_-_61902669 2.254 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr13_+_99100698 2.248 ENSMUST00000181742.1
Gm807
predicted gene 807
chr2_+_132847719 2.053 ENSMUST00000124836.1
ENSMUST00000154160.1
Crls1

cardiolipin synthase 1

chr5_+_135106881 2.038 ENSMUST00000005507.3
Mlxipl
MLX interacting protein-like
chr3_-_154328634 1.945 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr19_-_19001099 1.902 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb

RAR-related orphan receptor beta

chr6_-_138426735 1.867 ENSMUST00000162932.1
Lmo3
LIM domain only 3
chr12_+_38780817 1.835 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr2_-_168767136 1.784 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr8_-_92355764 1.748 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr10_-_70655934 1.688 ENSMUST00000162144.1
ENSMUST00000162793.1
Phyhipl

phytanoyl-CoA hydroxylase interacting protein-like

chr4_-_14621669 1.627 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr11_-_89538556 1.588 ENSMUST00000169201.1
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr1_-_119053619 1.580 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr4_-_14621805 1.379 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr5_+_139543889 1.357 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr7_-_116031047 1.347 ENSMUST00000106612.1
Sox6
SRY-box containing gene 6
chr11_+_60537978 1.330 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr4_+_115088708 1.309 ENSMUST00000171877.1
ENSMUST00000177647.1
ENSMUST00000106548.2
ENSMUST00000030488.2
Pdzk1ip1



PDZK1 interacting protein 1



chr4_+_102589687 1.256 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr19_+_24875679 1.239 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr10_-_92164666 1.218 ENSMUST00000183123.1
ENSMUST00000182033.1
Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr15_-_50882806 1.218 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr18_-_15063560 1.140 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chrX_-_53269786 1.123 ENSMUST00000114841.1
ENSMUST00000071023.5
Fam122b

family with sequence similarity 122, member B

chr14_-_118052235 1.085 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr1_+_143777263 1.082 ENSMUST00000018333.6
Uchl5
ubiquitin carboxyl-terminal esterase L5
chr4_+_150237694 1.075 ENSMUST00000141931.1
Eno1
enolase 1, alpha non-neuron
chr13_-_102905740 1.072 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr8_-_67818218 1.062 ENSMUST00000059374.4
Psd3
pleckstrin and Sec7 domain containing 3
chr13_-_102906046 1.032 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr2_-_106002008 0.997 ENSMUST00000155811.1
Dnajc24
DnaJ (Hsp40) homolog, subfamily C, member 24
chrX_-_59166080 0.996 ENSMUST00000119306.1
Fgf13
fibroblast growth factor 13
chr5_-_62766153 0.966 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_34592248 0.924 ENSMUST00000038149.6
Pbx2
pre B cell leukemia homeobox 2
chr1_+_10993452 0.882 ENSMUST00000027056.5
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_+_56447965 0.881 ENSMUST00000079663.6
Gm2174
predicted gene 2174
chr16_-_59632520 0.879 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr4_+_5724304 0.840 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr9_-_37147257 0.834 ENSMUST00000039674.5
ENSMUST00000080754.5
Pknox2

Pbx/knotted 1 homeobox 2

chr4_+_150237211 0.832 ENSMUST00000133839.1
Eno1
enolase 1, alpha non-neuron
chr4_-_14621494 0.806 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr18_-_88927447 0.785 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr10_-_128549125 0.720 ENSMUST00000177163.1
ENSMUST00000176683.1
ENSMUST00000176010.1
Rpl41


ribosomal protein L41


chrX_+_16619698 0.701 ENSMUST00000026013.5
Maoa
monoamine oxidase A
chr14_-_69805524 0.666 ENSMUST00000022665.2
Rhobtb2
Rho-related BTB domain containing 2
chr6_+_29859374 0.663 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr6_+_29859686 0.660 ENSMUST00000134438.1
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr6_+_29859662 0.616 ENSMUST00000128927.2
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr10_-_128549102 0.615 ENSMUST00000176906.1
Rpl41
ribosomal protein L41
chr9_+_15239045 0.609 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr2_+_3114220 0.593 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chrX_+_99975570 0.544 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr10_-_53647080 0.537 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr4_-_133602168 0.476 ENSMUST00000057311.3
Sfn
stratifin
chr17_-_3557713 0.475 ENSMUST00000041003.6
Tfb1m
transcription factor B1, mitochondrial
chr7_+_28881656 0.395 ENSMUST00000066880.4
Capn12
calpain 12
chr10_-_95673451 0.366 ENSMUST00000099328.1
Anapc15-ps
anaphase prompoting complex C subunit 15, pseudogene
chr6_+_125552948 0.355 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr12_-_112511136 0.337 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr2_-_148045891 0.327 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr9_+_53771499 0.303 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr17_+_46681038 0.300 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr17_+_17402672 0.288 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr8_-_84662841 0.249 ENSMUST00000060427.4
Ier2
immediate early response 2
chrX_+_9885622 0.191 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr13_-_38635036 0.180 ENSMUST00000035899.6
Bloc1s5
biogenesis of organelles complex-1, subunit 5, muted
chr13_-_103764502 0.172 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr2_-_33718789 0.167 ENSMUST00000130532.1
9430024E24Rik
RIKEN cDNA 9430024E24 gene
chr8_+_4238815 0.107 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr3_-_88552859 0.022 ENSMUST00000119002.1
ENSMUST00000029698.8
Lamtor2

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
2.1 6.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
2.0 6.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.7 5.1 GO:0021759 globus pallidus development(GO:0021759)
1.6 4.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.5 19.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.3 5.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.2 3.6 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
1.0 3.0 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
1.0 6.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.9 7.7 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.8 5.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.5 3.8 GO:0019532 oxalate transport(GO:0019532)
0.5 2.0 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.4 6.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 1.6 GO:0060032 notochord regression(GO:0060032)
0.3 1.3 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.3 1.9 GO:0046549 retinal cone cell development(GO:0046549)
0.3 2.1 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.3 4.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 1.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 4.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 0.7 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 2.6 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 6.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 1.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 0.5 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 1.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 1.6 GO:0050957 equilibrioception(GO:0050957)
0.2 1.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 2.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 2.9 GO:0001553 luteinization(GO:0001553)
0.1 0.9 GO:0046909 intermembrane transport(GO:0046909)
0.1 1.0 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 1.3 GO:0001780 neutrophil homeostasis(GO:0001780)
0.1 4.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 1.1 GO:0048853 forebrain morphogenesis(GO:0048853)
0.1 0.2 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 0.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 1.2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 1.9 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 2.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.0 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.5 GO:0000154 rRNA modification(GO:0000154)
0.0 0.8 GO:0050868 negative regulation of T cell activation(GO:0050868)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.5 19.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 6.7 GO:0043196 varicosity(GO:0043196)
0.3 1.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 3.0 GO:0097449 astrocyte projection(GO:0097449)
0.1 1.6 GO:0097542 ciliary tip(GO:0097542)
0.1 2.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 2.3 GO:0002102 podosome(GO:0002102)
0.1 1.1 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 5.0 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 5.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 4.4 GO:0000792 heterochromatin(GO:0000792)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)
0.0 6.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0070382 exocytic vesicle(GO:0070382)
0.0 1.7 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
1.0 3.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.0 5.7 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.8 5.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.7 5.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.6 1.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.6 6.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.5 19.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.5 2.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.4 5.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.4 2.1 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.4 4.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.4 11.6 GO:0008009 chemokine activity(GO:0008009)
0.4 0.7 GO:0051378 serotonin binding(GO:0051378)
0.3 3.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 1.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.3 6.1 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.3 1.9 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 6.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 3.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.1 GO:0070628 proteasome binding(GO:0070628)
0.0 1.0 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 3.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 24.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)