Motif ID: Prop1

Z-value: 0.887


Transcription factors associated with Prop1:

Gene SymbolEntrez IDGene Name
Prop1 ENSMUSG00000044542.3 Prop1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prop1mm10_v2_chr11_-_50953745_509537680.056.6e-01Click!


Activity profile for motif Prop1.

activity profile for motif Prop1


Sorted Z-values histogram for motif Prop1

Sorted Z-values for motif Prop1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prop1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_61804453 8.413 ENSMUST00000048934.8
Tbr1
T-box brain gene 1
chr14_-_40893222 6.427 ENSMUST00000096000.3
Sh2d4b
SH2 domain containing 4B
chr18_-_66860458 5.262 ENSMUST00000057942.2
Mc4r
melanocortin 4 receptor
chr9_+_118478182 4.693 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr4_-_119492563 4.522 ENSMUST00000049994.7
Rimkla
ribosomal modification protein rimK-like family member A
chr4_-_110292719 4.497 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_+_107511416 3.998 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr9_+_118478344 3.983 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr18_-_62741387 3.923 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr1_-_176807124 3.861 ENSMUST00000057037.7
Cep170
centrosomal protein 170
chr14_+_75455957 3.822 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chr10_-_109009055 3.676 ENSMUST00000156979.1
Syt1
synaptotagmin I
chr10_+_69925766 3.518 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
Ank3


ankyrin 3, epithelial


chr10_+_69925954 3.421 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
Ank3


ankyrin 3, epithelial


chr10_+_69925484 3.419 ENSMUST00000182692.1
ENSMUST00000092433.5
Ank3

ankyrin 3, epithelial

chr13_+_94875600 3.352 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr3_+_94377432 3.340 ENSMUST00000107292.1
Rorc
RAR-related orphan receptor gamma
chr2_-_112480817 3.034 ENSMUST00000099589.2
Chrm5
cholinergic receptor, muscarinic 5
chr2_+_82053222 2.993 ENSMUST00000047527.7
Zfp804a
zinc finger protein 804A
chr10_-_45470201 2.924 ENSMUST00000079390.6
Lin28b
lin-28 homolog B (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 12.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.9 8.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.7 8.4 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.9 6.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
1.3 5.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.1 5.3 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.5 5.2 GO:0007379 segment specification(GO:0007379)
0.1 4.6 GO:0043488 regulation of mRNA stability(GO:0043488)
0.3 4.5 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.8 3.9 GO:0060467 negative regulation of fertilization(GO:0060467)
0.8 3.8 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.5 3.7 GO:0005513 detection of calcium ion(GO:0005513)
0.2 3.4 GO:0021979 hypothalamus cell differentiation(GO:0021979)
1.1 3.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.5 3.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3 2.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.9 2.8 GO:0007210 serotonin receptor signaling pathway(GO:0007210)
0.5 2.8 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.3 2.4 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2 2.3 GO:0021796 cerebral cortex regionalization(GO:0021796)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 5.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 5.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 4.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 4.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 4.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 4.3 GO:0005814 centriole(GO:0005814)
0.2 3.7 GO:0031045 dense core granule(GO:0031045)
1.1 3.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 2.8 GO:0070852 cell body fiber(GO:0070852)
0.0 2.8 GO:0015935 small ribosomal subunit(GO:0015935)
0.4 2.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.3 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 2.1 GO:0031526 brush border membrane(GO:0031526)
0.4 1.9 GO:0008623 CHRAC(GO:0008623)
0.3 1.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.7 GO:0030016 myofibril(GO:0030016)
0.2 1.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 9.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 8.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 7.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.6 6.2 GO:0008142 oxysterol binding(GO:0008142)
1.8 5.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 4.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 4.5 GO:0017091 AU-rich element binding(GO:0017091)
0.0 4.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 4.3 GO:0005496 steroid binding(GO:0005496)
0.2 3.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 3.5 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.4 3.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
1.0 3.0 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 3.0 GO:0008565 protein transporter activity(GO:0008565)
0.0 3.0 GO:0017124 SH3 domain binding(GO:0017124)
0.7 2.8 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)
0.3 2.7 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 2.5 GO:0005507 copper ion binding(GO:0005507)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)