Motif ID: Prox1

Z-value: 0.478


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.636.0e-09Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169747634 2.654 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr15_-_80014808 2.180 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr10_-_81025521 1.918 ENSMUST00000144640.1
Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_+_130913264 1.651 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr4_+_130913120 1.548 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr10_-_81025406 1.493 ENSMUST00000055125.4
Diras1
DIRAS family, GTP-binding RAS-like 1
chr5_-_37824580 1.267 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr4_-_36951223 1.242 ENSMUST00000108122.1
Lingo2
leucine rich repeat and Ig domain containing 2
chr4_+_42950369 1.188 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_-_20682963 1.090 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chrX_-_43274786 1.081 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr12_-_83487708 1.041 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr6_+_58640536 1.038 ENSMUST00000145161.1
ENSMUST00000114294.1
Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr2_-_92459709 0.991 ENSMUST00000136718.1
ENSMUST00000067631.6
Slc35c1

solute carrier family 35, member C1

chr7_-_19458494 0.875 ENSMUST00000085715.5
Mark4
MAP/microtubule affinity-regulating kinase 4
chr19_+_60144682 0.828 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr19_-_43524462 0.805 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr6_-_131388417 0.796 ENSMUST00000032309.6
ENSMUST00000087865.2
Ybx3

Y box protein 3

chr7_-_127448993 0.793 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr11_+_4986824 0.759 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.7 2.2 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.4 1.3 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 1.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 1.0 GO:0046618 drug export(GO:0046618)
0.2 1.0 GO:0030259 lipid glycosylation(GO:0030259)
0.0 1.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.3 0.8 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.3 0.8 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.8 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.3 0.6 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.6 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.2 0.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.0 GO:0071565 nBAF complex(GO:0071565)
0.1 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.6 GO:0000243 commitment complex(GO:0000243)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 2.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.8 GO:0051087 chaperone binding(GO:0051087)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.3 GO:0002039 p53 binding(GO:0002039)
0.2 1.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 0.8 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.6 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.6 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)
0.2 0.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.5 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.5 GO:0031418 L-ascorbic acid binding(GO:0031418)