Motif ID: Prox1

Z-value: 0.478


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.636.0e-09Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169747634 2.654 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr15_-_80014808 2.180 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr10_-_81025521 1.918 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_+_130913264 1.651 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr4_+_130913120 1.548 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr10_-_81025406 1.493 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr5_-_37824580 1.267 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr4_-_36951223 1.242 ENSMUST00000108122.1
 Lingo2
leucine rich repeat and Ig domain containing 2
chr4_+_42950369 1.188 ENSMUST00000084662.5
 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_-_20682963 1.090 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chrX_-_43274786 1.081 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr12_-_83487708 1.041 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr6_+_58640536 1.038 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr2_-_92459709 0.991 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chr7_-_19458494 0.875 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr19_+_60144682 0.828 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr19_-_43524462 0.805 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr6_-_131388417 0.796 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr7_-_127448993 0.793 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr11_+_4986824 0.759 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.7 2.2 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.4 1.3 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 1.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 1.0 GO:0046618 drug export(GO:0046618)
0.2 1.0 GO:0030259 lipid glycosylation(GO:0030259)
0.0 1.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.3 0.8 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.3 0.8 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.8 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.3 0.6 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.6 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.2 0.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.0 GO:0071565 nBAF complex(GO:0071565)
0.1 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.6 GO:0000243 commitment complex(GO:0000243)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 2.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.8 GO:0051087 chaperone binding(GO:0051087)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.3 GO:0002039 p53 binding(GO:0002039)
0.2 1.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 0.8 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.6 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.6 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)
0.2 0.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.5 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.5 GO:0031418 L-ascorbic acid binding(GO:0031418)