Motif ID: Prox1

Z-value: 0.478


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.636.0e-09Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_169747634 2.654 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr15_-_80014808 2.180 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr10_-_81025521 1.918 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_+_130913264 1.651 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr4_+_130913120 1.548 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr10_-_81025406 1.493 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr5_-_37824580 1.267 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr4_-_36951223 1.242 ENSMUST00000108122.1
 Lingo2
leucine rich repeat and Ig domain containing 2
chr4_+_42950369 1.188 ENSMUST00000084662.5
 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_-_20682963 1.090 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chrX_-_43274786 1.081 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr12_-_83487708 1.041 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr6_+_58640536 1.038 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr2_-_92459709 0.991 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chr7_-_19458494 0.875 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr19_+_60144682 0.828 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr19_-_43524462 0.805 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr6_-_131388417 0.796 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr7_-_127448993 0.793 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr11_+_4986824 0.759 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr17_-_34959232 0.751 ENSMUST00000165202.1
ENSMUST00000172753.1
 Hspa1b

heat shock protein 1B

chr19_+_46056539 0.717 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
 Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr7_-_127449109 0.712 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689
chr2_-_168734236 0.631 ENSMUST00000109175.2
 Atp9a
ATPase, class II, type 9A
chr9_+_104569671 0.617 ENSMUST00000057742.8
 Cpne4
copine IV
chr11_+_19924354 0.610 ENSMUST00000093299.6
 Spred2
sprouty-related, EVH1 domain containing 2
chr11_+_19924403 0.608 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr12_-_36042476 0.598 ENSMUST00000020896.8
 Tspan13
tetraspanin 13
chr17_-_34972124 0.588 ENSMUST00000087328.2
ENSMUST00000179128.1
 Hspa1a

heat shock protein 1A

chr17_+_27839974 0.580 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr2_+_36230426 0.565 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr14_-_96519067 0.559 ENSMUST00000022666.7
 Klhl1
kelch-like 1
chr8_-_99416397 0.544 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chr9_-_106247730 0.520 ENSMUST00000112524.2
ENSMUST00000074082.6
 Alas1

aminolevulinic acid synthase 1

chr2_+_136891501 0.515 ENSMUST00000141463.1
 Slx4ip
SLX4 interacting protein
chr19_+_41911851 0.510 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr5_+_139211934 0.504 ENSMUST00000148772.1
ENSMUST00000110882.1
 Sun1

Sad1 and UNC84 domain containing 1

chr11_-_115933464 0.500 ENSMUST00000021097.3
 Recql5
RecQ protein-like 5
chr14_-_55944536 0.497 ENSMUST00000022834.6
 Cma1
chymase 1, mast cell
chrX_-_73966329 0.496 ENSMUST00000114372.2
ENSMUST00000033761.6
 Hcfc1

host cell factor C1

chr15_-_89149557 0.483 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr8_-_85080679 0.463 ENSMUST00000093357.5
 Wdr83
WD repeat domain containing 83
chr6_+_146796041 0.456 ENSMUST00000111639.1
 Arntl2
aryl hydrocarbon receptor nuclear translocator-like 2
chr11_-_120784183 0.451 ENSMUST00000026156.7
 Rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr5_+_124112297 0.451 ENSMUST00000024470.6
ENSMUST00000119269.1
 Ogfod2

2-oxoglutarate and iron-dependent oxygenase domain containing 2

chr7_+_24081888 0.450 ENSMUST00000068975.3
 Zfp180
zinc finger protein 180
chr19_+_46152505 0.434 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr17_+_37045963 0.410 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr10_-_81496313 0.409 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr8_+_85080939 0.408 ENSMUST00000140621.1
 BC056474
cDNA sequence BC056474
chr5_+_139252343 0.400 ENSMUST00000130326.1
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr2_+_27009936 0.382 ENSMUST00000133807.1
 Cacfd1
calcium channel flower domain containing 1
chr18_-_67245818 0.375 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr8_-_85080652 0.371 ENSMUST00000152785.1
 Wdr83
WD repeat domain containing 83
chr5_-_138187177 0.361 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr2_+_34406882 0.336 ENSMUST00000113123.1
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr10_-_81496329 0.330 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr2_+_34406949 0.328 ENSMUST00000040459.4
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr2_+_34406845 0.322 ENSMUST00000124443.1
ENSMUST00000113124.1
 Mapkap1

mitogen-activated protein kinase associated protein 1

chr9_-_64726583 0.320 ENSMUST00000168366.1
 Rab11a
RAB11a, member RAS oncogene family
chr11_+_120784257 0.319 ENSMUST00000100134.3
 Gps1
G protein pathway suppressor 1
chr2_+_27009926 0.303 ENSMUST00000114005.2
ENSMUST00000114004.1
ENSMUST00000114006.1
ENSMUST00000114007.1
 Cacfd1



calcium channel flower domain containing 1



chr7_-_126861648 0.289 ENSMUST00000129812.1
ENSMUST00000106342.1
 Ino80e

INO80 complex subunit E

chr4_-_131821516 0.284 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr7_+_127777095 0.272 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr17_-_70924958 0.270 ENSMUST00000180468.1
 Gm26510
predicted gene, 26510
chr9_-_110117303 0.258 ENSMUST00000136969.1
 Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr5_+_139252314 0.229 ENSMUST00000026976.5
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr17_+_47630690 0.228 ENSMUST00000024779.8
 Usp49
ubiquitin specific peptidase 49
chr7_-_80947499 0.218 ENSMUST00000120285.1
 Sec11a
SEC11 homolog A (S. cerevisiae)
chr2_-_167062981 0.211 ENSMUST00000048988.7
 Znfx1
zinc finger, NFX1-type containing 1
chr4_+_140701466 0.201 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr8_+_31111816 0.179 ENSMUST00000046941.7
 Rnf122
ring finger protein 122
chr1_-_160792908 0.171 ENSMUST00000028049.7
 Rabgap1l
RAB GTPase activating protein 1-like
chr17_-_83514311 0.168 ENSMUST00000167741.1
ENSMUST00000025095.7
 Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr2_-_26910569 0.164 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
 Med22


mediator complex subunit 22


chr11_+_72207537 0.148 ENSMUST00000021158.3
 Txndc17
thioredoxin domain containing 17
chr4_+_59003121 0.144 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr8_-_70476911 0.143 ENSMUST00000066597.5
ENSMUST00000166976.1
 Klhl26

kelch-like 26

chr18_-_12819842 0.112 ENSMUST00000119043.1
 Osbpl1a
oxysterol binding protein-like 1A
chr13_+_9276477 0.104 ENSMUST00000174552.1
 Dip2c
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr2_-_136891131 0.099 ENSMUST00000144275.1
 Mkks
McKusick-Kaufman syndrome
chr12_-_40223149 0.082 ENSMUST00000171553.1
ENSMUST00000001672.5
 Ifrd1

interferon-related developmental regulator 1

chr8_+_99416585 0.069 ENSMUST00000064349.5
 A330008L17Rik
RIKEN cDNA A330008L17 gene
chr14_-_59440779 0.065 ENSMUST00000111253.2
ENSMUST00000095775.3
ENSMUST00000161459.1
 Setdb2


SET domain, bifurcated 2


chr2_-_136891363 0.063 ENSMUST00000028730.6
ENSMUST00000110089.2
 Mkks

McKusick-Kaufman syndrome

chr7_+_28716846 0.031 ENSMUST00000108279.2
 Fbxo17
F-box protein 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.4 1.3 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.3 1.0 GO:0046618 drug export(GO:0046618)
0.3 0.6 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.3 0.8 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.3 0.8 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 1.0 GO:0030259 lipid glycosylation(GO:0030259)
0.2 0.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.4 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.5 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.5 GO:0019042 viral latency(GO:0019042)
0.1 0.5 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 1.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.5 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 0.6 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.2 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.3 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 2.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.8 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 0.5 GO:0009409 response to cold(GO:0009409)
0.0 0.5 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.0 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.6 GO:0000243 commitment complex(GO:0000243)
0.1 0.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 0.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 1.0 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 3.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.8 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3 0.8 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 1.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 1.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 0.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.6 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.6 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.5 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.3 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.5 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 1.8 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 1.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0016748 succinyltransferase activity(GO:0016748) N-succinyltransferase activity(GO:0016749)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)