Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.680

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx1mm10_v2_chr1_-_163313661_1633137100.694.3e-11Click!
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.301.2e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_122419772 9.586 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr12_+_79297345 6.857 ENSMUST00000079533.5
ENSMUST00000171210.1
Rad51b

RAD51 homolog B

chr2_-_71546745 5.406 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr3_+_159839729 5.279 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr19_-_43912392 4.807 ENSMUST00000026209.4
Dnmbp
dynamin binding protein
chr17_+_27556668 4.407 ENSMUST00000117254.1
ENSMUST00000118570.1
Hmga1

high mobility group AT-hook 1

chr12_+_117843489 4.388 ENSMUST00000021592.9
Cdca7l
cell division cycle associated 7 like
chr9_+_118478344 4.340 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr17_+_27556613 4.297 ENSMUST00000117600.1
ENSMUST00000114888.3
Hmga1

high mobility group AT-hook 1

chr10_-_42583628 4.129 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr17_+_27556641 4.107 ENSMUST00000119486.1
ENSMUST00000118599.1
Hmga1

high mobility group AT-hook 1

chr9_+_35423582 3.770 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr12_+_9029982 3.711 ENSMUST00000085741.1
Ttc32
tetratricopeptide repeat domain 32
chr15_-_8710734 3.557 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_9140374 3.458 ENSMUST00000096482.3
ENSMUST00000110585.2
Skp2

S-phase kinase-associated protein 2 (p45)

chr14_+_73237891 3.456 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr17_+_78508063 3.392 ENSMUST00000024880.9
Vit
vitrin
chr3_+_146121655 3.374 ENSMUST00000039450.4
Mcoln3
mucolipin 3
chr2_+_91257323 3.297 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr4_-_134767940 3.271 ENSMUST00000037828.6
Ldlrap1
low density lipoprotein receptor adaptor protein 1

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.8 GO:0006284 base-excision repair(GO:0006284)
0.3 9.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
1.7 6.9 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
1.6 6.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.0 6.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.3 5.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
1.8 5.4 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.4 5.3 GO:0031017 exocrine pancreas development(GO:0031017)
1.5 4.6 GO:0006566 threonine metabolic process(GO:0006566)
0.5 4.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.5 3.8 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.4 3.4 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.3 3.3 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.1 3.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 3.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.7 2.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 2.9 GO:0000076 DNA replication checkpoint(GO:0000076)
0.4 2.8 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 2.8 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.5 2.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.4 6.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.4 6.3 GO:0043205 fibril(GO:0043205)
0.2 5.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 4.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.8 3.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 3.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 2.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 2.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.6 2.5 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 2.4 GO:0005902 microvillus(GO:0005902)
0.0 2.4 GO:0043197 dendritic spine(GO:0043197)
0.2 2.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 2.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 2.2 GO:0045179 apical cortex(GO:0045179)
0.2 2.0 GO:0005916 fascia adherens(GO:0005916)
0.0 1.8 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 12.8 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 12.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
1.0 6.9 GO:0000150 recombinase activity(GO:0000150)
1.3 6.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 6.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 5.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 5.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 4.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 4.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 4.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 3.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 3.5 GO:0035497 cAMP response element binding(GO:0035497)
0.4 3.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 3.2 GO:0051287 NAD binding(GO:0051287)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 2.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.5 2.8 GO:0015265 urea channel activity(GO:0015265)
0.3 2.8 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 2.7 GO:0005096 GTPase activator activity(GO:0005096)
0.2 2.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)