Motif ID: Rad21_Smc3

Z-value: 0.838

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smc3mm10_v2_chr19_+_53600377_53600435-0.362.2e-03Click!
Rad21mm10_v2_chr15_-_51991679_51991760-0.142.6e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_74442551 5.164 ENSMUST00000121875.1
 Myo5b
myosin VB
chr18_+_74442500 4.985 ENSMUST00000074157.6
 Myo5b
myosin VB
chr13_+_98354234 4.963 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr2_+_167538192 4.899 ENSMUST00000052631.7
 Snai1
snail homolog 1 (Drosophila)
chr8_+_119446719 3.967 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr10_-_31445921 3.833 ENSMUST00000000305.5
 Tpd52l1
tumor protein D52-like 1
chr2_-_166155272 3.824 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr2_-_117342709 3.717 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr2_-_158146385 3.683 ENSMUST00000103122.3
 Tgm2
transglutaminase 2, C polypeptide
chr19_-_10240689 3.664 ENSMUST00000088013.5
 Myrf
myelin regulatory factor
chr4_+_100095791 3.398 ENSMUST00000039630.5
 Ror1
receptor tyrosine kinase-like orphan receptor 1
chr11_-_59964936 3.204 ENSMUST00000062405.7
 Rasd1
RAS, dexamethasone-induced 1
chr2_+_26586607 3.167 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr7_+_16891755 2.941 ENSMUST00000078182.4
 Gng8
guanine nucleotide binding protein (G protein), gamma 8
chr7_+_25686994 2.905 ENSMUST00000002678.9
 Tgfb1
transforming growth factor, beta 1
chr8_+_87473116 2.897 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr5_+_30921556 2.874 ENSMUST00000031053.8
 Khk
ketohexokinase
chr4_+_63215402 2.867 ENSMUST00000036300.6
 Col27a1
collagen, type XXVII, alpha 1
chr7_+_35119285 2.826 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr3_-_84155762 2.772 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 10.1 GO:0032439 endosome localization(GO:0032439)
2.6 7.8 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
1.3 5.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.7 5.0 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
1.6 4.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 4.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 4.5 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
1.2 3.7 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.4 3.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 3.6 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.1 3.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 3.4 GO:0051321 meiotic cell cycle(GO:0051321)
0.1 3.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 3.2 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.6 3.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
1.0 2.9 GO:0002295 T-helper cell lineage commitment(GO:0002295) evasion or tolerance of host defenses by virus(GO:0019049) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) positive regulation of mononuclear cell migration(GO:0071677) negative regulation of hyaluronan biosynthetic process(GO:1900126) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.6 2.9 GO:0019236 response to pheromone(GO:0019236)
0.6 2.9 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.4 2.8 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.5 2.7 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 10.4 GO:0045179 apical cortex(GO:0045179)
0.0 7.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 6.9 GO:0005769 early endosome(GO:0005769)
0.1 5.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 4.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 4.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.8 GO:0005844 polysome(GO:0005844)
0.0 3.2 GO:0005902 microvillus(GO:0005902)
1.0 3.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 3.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 3.1 GO:0043235 receptor complex(GO:0043235)
0.2 2.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 2.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 2.4 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.2 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.1 GO:0005921 gap junction(GO:0005921)
0.3 2.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.9 GO:0000794 condensed nuclear chromosome(GO:0000794)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.6 7.8 GO:0004454 ketohexokinase activity(GO:0004454)
0.2 7.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 6.6 GO:0005525 GTP binding(GO:0005525)
0.1 6.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 5.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 5.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 5.0 GO:0008301 DNA binding, bending(GO:0008301)
0.2 4.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.4 4.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.9 3.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.5 3.4 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 3.4 GO:0005112 Notch binding(GO:0005112)
0.1 3.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.7 2.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 2.8 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 2.8 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.3 2.6 GO:0008097 5S rRNA binding(GO:0008097)
0.1 2.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)