Motif ID: Rara

Z-value: 0.601


Transcription factors associated with Rara:

Gene SymbolEntrez IDGene Name
Rara ENSMUSG00000037992.10 Rara

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raramm10_v2_chr11_+_98927785_989278180.235.7e-02Click!


Activity profile for motif Rara.

activity profile for motif Rara


Sorted Z-values histogram for motif Rara

Sorted Z-values for motif Rara



Network of associatons between targets according to the STRING database.



First level regulatory network of Rara

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_141599835 6.041 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr13_+_94875600 4.858 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr3_-_54915867 3.702 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr12_+_87026564 3.307 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr4_+_150853919 2.427 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr2_+_169633517 2.364 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr4_+_48045144 2.225 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr17_-_56133817 2.220 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr17_+_34593388 2.157 ENSMUST00000174532.1
 Pbx2
pre B cell leukemia homeobox 2
chr4_-_46991842 1.993 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr8_-_94876269 1.963 ENSMUST00000046461.7
 Dok4
docking protein 4
chr4_+_32238950 1.669 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr11_+_98960412 1.645 ENSMUST00000107473.2
 Rara
retinoic acid receptor, alpha
chr14_+_58070547 1.604 ENSMUST00000165526.1
 Fgf9
fibroblast growth factor 9
chr12_-_108893197 1.589 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr10_-_89257790 1.464 ENSMUST00000045601.7
 Ano4
anoctamin 4
chr14_+_55618023 1.444 ENSMUST00000002395.7
 Rec8
REC8 homolog (yeast)
chr11_-_5915124 1.423 ENSMUST00000109823.2
ENSMUST00000109822.1
 Gck

glucokinase

chr14_-_16575456 1.308 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr11_+_94629741 1.281 ENSMUST00000021239.6
 Lrrc59
leucine rich repeat containing 59
chr6_+_91157373 1.261 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr7_-_141429351 1.227 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chrX_-_59567348 1.225 ENSMUST00000124402.1
 Fgf13
fibroblast growth factor 13
chr14_+_76488436 1.172 ENSMUST00000101618.2
 Tsc22d1
TSC22 domain family, member 1
chr14_-_74947865 1.112 ENSMUST00000088970.5
 Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr8_+_106150359 1.110 ENSMUST00000034377.6
 Pla2g15
phospholipase A2, group XV
chr2_+_26319741 1.102 ENSMUST00000066889.6
 Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr10_+_21993890 1.068 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr7_-_141429433 1.044 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chr11_+_4986824 1.009 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr6_+_30723541 0.982 ENSMUST00000115127.1
 Mest
mesoderm specific transcript
chr1_+_134037490 0.949 ENSMUST00000162779.1
 Fmod
fibromodulin
chr5_+_135806859 0.932 ENSMUST00000126232.1
 Srrm3
serine/arginine repetitive matrix 3
chr4_+_32238713 0.905 ENSMUST00000108180.2
 Bach2
BTB and CNC homology 2
chr4_-_128609981 0.895 ENSMUST00000141040.1
ENSMUST00000147876.1
ENSMUST00000097877.2
 Zscan20


zinc finger and SCAN domains 20


chr6_+_115601907 0.883 ENSMUST00000000449.7
 Mkrn2
makorin, ring finger protein, 2
chr9_-_109074049 0.866 ENSMUST00000161521.1
ENSMUST00000045011.2
 Atrip

ATR interacting protein

chr2_-_34754364 0.863 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
 Gapvd1


GTPase activating protein and VPS9 domains 1


chr10_+_79910856 0.831 ENSMUST00000181321.1
 Gm26602
predicted gene, 26602
chr7_+_120635176 0.768 ENSMUST00000033176.5
 Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr11_-_97700327 0.673 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr9_-_43105718 0.667 ENSMUST00000165665.1
 Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr14_+_20674311 0.646 ENSMUST00000048657.8
 Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr1_-_175692624 0.636 ENSMUST00000027809.7
 Opn3
opsin 3
chr2_+_181365384 0.536 ENSMUST00000108807.2
 Zgpat
zinc finger, CCCH-type with G patch domain
chr14_+_64588112 0.521 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr2_-_5845164 0.506 ENSMUST00000043864.3
 Cdc123
cell division cycle 123
chrX_+_74254782 0.493 ENSMUST00000119197.1
ENSMUST00000088313.4
 Emd

emerin

chr4_-_152318458 0.439 ENSMUST00000170820.1
ENSMUST00000076183.5
 Rnf207

ring finger protein 207

chr9_+_54586450 0.432 ENSMUST00000167866.1
 Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr3_+_152210458 0.419 ENSMUST00000166984.1
ENSMUST00000106121.1
 Fubp1

far upstream element (FUSE) binding protein 1

chrX_+_74254736 0.376 ENSMUST00000096424.4
 Emd
emerin
chr6_+_18848571 0.346 ENSMUST00000056398.8
 Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr11_-_50953745 0.339 ENSMUST00000162420.1
ENSMUST00000051159.2
 Prop1

paired like homeodomain factor 1

chr7_+_45873127 0.335 ENSMUST00000107718.1
 Kdelr1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr10_+_19951055 0.307 ENSMUST00000152533.1
 Map3k5
mitogen-activated protein kinase kinase kinase 5
chr8_-_119778380 0.279 ENSMUST00000049156.5
 Tldc1
TBC/LysM associated domain containing 1
chr17_-_32388885 0.257 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr2_-_181365306 0.242 ENSMUST00000108808.1
ENSMUST00000170190.1
ENSMUST00000127988.1
 Arfrp1


ADP-ribosylation factor related protein 1


chrX_+_106187100 0.168 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr13_+_49421229 0.162 ENSMUST00000021817.8
 Ippk
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr7_+_45872772 0.155 ENSMUST00000002855.5
ENSMUST00000107719.1
 Kdelr1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr1_-_163403627 0.136 ENSMUST00000045138.4
 Gorab
golgin, RAB6-interacting
chr7_-_17056669 0.131 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr4_+_41348996 0.118 ENSMUST00000072866.5
ENSMUST00000108060.3
 Ubap1

ubiquitin-associated protein 1

chr2_+_120977017 0.095 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chrX_-_75874536 0.092 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr2_+_131262469 0.080 ENSMUST00000150843.1
 Pank2
pantothenate kinase 2
chr8_+_11556061 0.075 ENSMUST00000054399.4
 Ing1
inhibitor of growth family, member 1
chr2_+_5845017 0.059 ENSMUST00000026927.3
ENSMUST00000179748.1
 Nudt5

nudix (nucleoside diphosphate linked moiety X)-type motif 5

chr3_-_36475688 0.039 ENSMUST00000029266.8
 Anxa5
annexin A5
chr4_+_141444654 0.035 ENSMUST00000006377.6
 Zbtb17
zinc finger and BTB domain containing 17
chr8_+_69659263 0.031 ENSMUST00000169125.1
 Zfp964
zinc finger protein 964
chr5_+_138255608 0.024 ENSMUST00000062067.6
 Lamtor4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.8 2.3 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.7 2.2 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.5 1.6 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.5 1.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.5 1.5 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.5 1.4 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.4 6.0 GO:0033623 regulation of integrin activation(GO:0033623)
0.4 5.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.2 1.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 1.2 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.2 0.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.2 1.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 1.4 GO:0007141 male meiosis I(GO:0007141)
0.1 1.6 GO:0060484 male sex determination(GO:0030238) lung-associated mesenchyme development(GO:0060484)
0.1 0.4 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.1 0.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 1.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 2.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 2.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.4 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 2.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.9 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 1.0 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.3 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 1.3 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.9 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.1 GO:1904251 regulation of bile acid metabolic process(GO:1904251)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 1.4 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 0.8 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.4 GO:0045180 basal cortex(GO:0045180)
0.1 0.7 GO:0001739 sex chromatin(GO:0001739)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.9 GO:0005652 nuclear lamina(GO:0005652)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.3 GO:0014704 intercalated disc(GO:0014704)
0.0 2.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.4 6.0 GO:0031005 filamin binding(GO:0031005)
0.3 2.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.3 2.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 1.4 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.2 0.6 GO:0009881 photoreceptor activity(GO:0009881)
0.2 1.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.4 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 4.8 GO:0022839 ion gated channel activity(GO:0022839)
0.1 1.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 0.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 1.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.7 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 2.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.0 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 2.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.0 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 2.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)