Motif ID: Rela_Rel_Nfkb1

Z-value: 1.683

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1mm10_v2_chr3_-_135608221_1356082900.821.9e-18Click!
Relamm10_v2_chr19_+_5637475_56374860.381.2e-03Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_165234689 32.307 ENSMUST00000065438.6
 Cdh22
cadherin 22
chr7_-_25788635 27.487 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr15_-_79164477 21.254 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr8_-_61902669 20.453 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr1_+_74791516 19.182 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr7_-_103843154 18.988 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr6_+_4755327 18.303 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr19_+_46304709 17.109 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr18_+_4994600 15.293 ENSMUST00000140448.1
 Svil
supervillin
chr17_-_35000848 14.810 ENSMUST00000166828.3
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr6_+_48841476 13.305 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr14_-_70642268 12.928 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr12_+_79029150 12.572 ENSMUST00000039928.5
 Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr6_+_48841633 12.399 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr7_-_102250086 12.212 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr5_+_92925400 11.876 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr17_-_35000746 11.395 ENSMUST00000163360.1
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr13_+_33964659 9.789 ENSMUST00000021843.5
ENSMUST00000058978.7
 Nqo2

NAD(P)H dehydrogenase, quinone 2

chr6_-_24956106 9.680 ENSMUST00000127247.2
 Tmem229a
transmembrane protein 229A
chr3_-_135691512 9.605 ENSMUST00000029812.7
 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 258 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.8 47.5 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
4.6 27.5 GO:0048549 positive regulation of pinocytosis(GO:0048549)
1.3 24.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.4 22.0 GO:0002467 germinal center formation(GO:0002467)
2.0 21.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
2.1 21.3 GO:0048484 enteric nervous system development(GO:0048484)
2.0 20.4 GO:0008063 Toll signaling pathway(GO:0008063)
1.5 20.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
3.8 19.0 GO:0015671 oxygen transport(GO:0015671)
0.3 18.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 15.9 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.3 14.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
2.1 14.4 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
2.7 13.7 GO:0046601 positive regulation of centriole replication(GO:0046601)
1.1 13.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.5 12.2 GO:1900027 regulation of ruffle assembly(GO:1900027)
2.0 11.9 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.9 11.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.7 10.4 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
2.5 10.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.4 37.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 31.3 GO:0031225 anchored component of membrane(GO:0031225)
1.3 27.5 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.1 24.4 GO:0005925 focal adhesion(GO:0005925)
0.9 23.7 GO:0002102 podosome(GO:0002102)
2.9 23.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
2.4 19.0 GO:0005833 hemoglobin complex(GO:0005833)
0.2 17.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5 17.7 GO:0043034 costamere(GO:0043034)
0.1 17.0 GO:0000922 spindle pole(GO:0000922)
1.1 16.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 14.5 GO:0005667 transcription factor complex(GO:0005667)
1.7 13.7 GO:0098536 deuterosome(GO:0098536)
0.1 12.1 GO:0043209 myelin sheath(GO:0043209)
0.3 11.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 11.4 GO:0005882 intermediate filament(GO:0005882)
0.1 11.4 GO:0043296 apical junction complex(GO:0043296)
1.8 10.6 GO:0030127 COPII vesicle coat(GO:0030127)
1.0 10.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.9 9.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 72.6 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 33.6 GO:0051015 actin filament binding(GO:0051015)
0.4 33.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 30.9 GO:0005178 integrin binding(GO:0005178)
0.1 27.6 GO:0005509 calcium ion binding(GO:0005509)
2.7 27.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.6 22.3 GO:0005109 frizzled binding(GO:0005109)
0.0 20.7 GO:0044822 poly(A) RNA binding(GO:0044822)
1.7 20.4 GO:0031996 thioesterase binding(GO:0031996)
4.7 19.0 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 14.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 13.5 GO:0005525 GTP binding(GO:0005525)
1.5 13.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 13.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
4.3 12.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.7 12.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.6 11.5 GO:0035497 cAMP response element binding(GO:0035497)
0.2 11.2 GO:0019003 GDP binding(GO:0019003)
0.4 10.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.8 9.2 GO:0019215 intermediate filament binding(GO:0019215)