Motif ID: Rest

Z-value: 3.893


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.581.8e-07Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_42255704 145.517 ENSMUST00000087123.5
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chrX_-_73869804 140.187 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr18_-_31447383 90.784 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr6_-_121473630 83.873 ENSMUST00000046373.5
Iqsec3
IQ motif and Sec7 domain 3
chr11_-_35798884 72.542 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr15_-_76521902 71.012 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr9_+_40269430 65.671 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr11_+_80477015 65.231 ENSMUST00000053413.10
ENSMUST00000147694.1
Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr3_-_80802789 63.607 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr2_+_153031852 61.441 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr1_+_34579693 60.629 ENSMUST00000052670.8
Amer3
APC membrane recruitment 3
chr9_+_40269202 57.965 ENSMUST00000114956.3
ENSMUST00000049941.5
Scn3b

sodium channel, voltage-gated, type III, beta

chr4_+_101550411 57.249 ENSMUST00000094953.4
ENSMUST00000106933.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr9_+_40269273 56.485 ENSMUST00000176185.1
Scn3b
sodium channel, voltage-gated, type III, beta
chr2_-_25319095 49.093 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr2_+_132781278 49.028 ENSMUST00000028826.3
Chgb
chromogranin B
chr11_+_77930800 48.799 ENSMUST00000093995.3
ENSMUST00000000646.7
Sez6

seizure related gene 6

chr4_-_129121234 48.718 ENSMUST00000030572.3
Hpca
hippocalcin
chr12_-_112511136 47.836 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr17_-_91092715 46.581 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
20.0 180.1 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
35.7 142.9 GO:0021586 pons maturation(GO:0021586)
14.0 140.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
11.3 90.8 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
4.5 89.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
3.4 83.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
14.5 72.5 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
1.5 71.0 GO:2001222 regulation of neuron migration(GO:2001222)
3.3 63.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
9.2 55.4 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 52.7 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
3.5 52.3 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
2.3 48.8 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
16.2 48.7 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
9.3 46.6 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
4.0 44.4 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
14.4 43.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
14.3 42.8 GO:0001661 conditioned taste aversion(GO:0001661)
0.6 42.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.4 40.7 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 287.2 GO:0042734 presynaptic membrane(GO:0042734)
0.2 218.7 GO:0005794 Golgi apparatus(GO:0005794)
11.3 180.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 169.8 GO:0016021 integral component of membrane(GO:0016021)
0.1 149.2 GO:0005886 plasma membrane(GO:0005886)
2.6 100.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
6.1 90.8 GO:0031045 dense core granule(GO:0031045)
8.1 89.6 GO:1904115 axon cytoplasm(GO:1904115)
2.1 80.7 GO:0097440 apical dendrite(GO:0097440)
19.4 77.7 GO:0044307 dendritic branch(GO:0044307)
9.1 72.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
21.7 65.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
2.0 61.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 59.7 GO:0030141 secretory granule(GO:0030141)
0.2 54.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
4.9 48.7 GO:0044327 dendritic spine head(GO:0044327)
1.6 47.8 GO:0060077 inhibitory synapse(GO:0060077)
3.9 42.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 42.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
6.6 39.6 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 407.3 GO:0003674 molecular_function(GO:0003674)
25.7 180.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
28.0 140.2 GO:0033691 sialic acid binding(GO:0033691)
3.1 88.9 GO:0001786 phosphatidylserine binding(GO:0001786)
2.3 83.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
7.1 77.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.1 72.5 GO:0042054 histone methyltransferase activity(GO:0042054)
2.8 65.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
2.9 64.0 GO:0017075 syntaxin-1 binding(GO:0017075)
10.6 63.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.6 62.5 GO:0051219 phosphoprotein binding(GO:0051219)
1.2 60.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.5 57.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 48.7 GO:0003779 actin binding(GO:0003779)
3.9 46.6 GO:0097109 neuroligin family protein binding(GO:0097109)
1.0 44.4 GO:0045296 cadherin binding(GO:0045296)
3.9 42.8 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
1.6 42.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.9 39.6 GO:0030507 spectrin binding(GO:0030507)
0.1 36.7 GO:0008022 protein C-terminus binding(GO:0008022)