Motif ID: Rfx3_Rfx1_Rfx4

Z-value: 2.468

Transcription factors associated with Rfx3_Rfx1_Rfx4:

Gene SymbolEntrez IDGene Name
Rfx1 ENSMUSG00000031706.6 Rfx1
Rfx3 ENSMUSG00000040929.10 Rfx3
Rfx4 ENSMUSG00000020037.9 Rfx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx4mm10_v2_chr10_+_84756055_84756084-0.597.3e-08Click!
Rfx3mm10_v2_chr19_-_28010995_280110540.171.6e-01Click!
Rfx1mm10_v2_chr8_+_84066824_840668820.047.4e-01Click!


Activity profile for motif Rfx3_Rfx1_Rfx4.

activity profile for motif Rfx3_Rfx1_Rfx4


Sorted Z-values histogram for motif Rfx3_Rfx1_Rfx4

Sorted Z-values for motif Rfx3_Rfx1_Rfx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7919816 46.232 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr10_-_81472859 28.027 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr11_-_6606053 23.885 ENSMUST00000045713.3
 Nacad
NAC alpha domain containing
chr15_+_98167806 22.569 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr7_-_140082246 19.736 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr7_-_4546567 19.104 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr7_-_140082489 18.914 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr12_+_29528382 17.156 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr7_+_99268338 16.863 ENSMUST00000107100.2
 Map6
microtubule-associated protein 6
chr1_-_60043087 16.814 ENSMUST00000027172.6
 Ica1l
islet cell autoantigen 1-like
chr5_+_24985840 16.494 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr9_+_59589288 16.060 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr10_+_80295930 15.199 ENSMUST00000105359.1
 Apc2
adenomatosis polyposis coli 2
chr7_-_31051431 15.070 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr19_-_46327121 14.888 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr11_+_70029742 14.819 ENSMUST00000132597.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr17_+_34629533 14.522 ENSMUST00000015620.6
 Prrt1
proline-rich transmembrane protein 1
chr11_-_61453992 14.044 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
 Rnf112


ring finger protein 112


chr4_+_152338619 13.867 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr1_+_66386968 13.686 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 46.2 GO:0016486 response to dietary excess(GO:0002021) peptide hormone processing(GO:0016486)
1.8 40.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 38.1 GO:0030032 lamellipodium assembly(GO:0030032)
2.1 27.9 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
5.4 26.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.3 25.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.6 25.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.9 23.4 GO:0060074 synapse maturation(GO:0060074)
0.7 23.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
5.3 21.4 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
1.1 21.2 GO:0071625 vocalization behavior(GO:0071625)
0.7 17.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.4 17.2 GO:0032418 lysosome localization(GO:0032418)
0.3 16.4 GO:0022900 electron transport chain(GO:0022900)
3.0 15.2 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
3.0 14.9 GO:0032423 regulation of mismatch repair(GO:0032423)
2.9 14.7 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.7 14.6 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
1.6 14.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.3 13.3 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 54.8 GO:0005802 trans-Golgi network(GO:0005802)
0.4 38.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 34.4 GO:0097708 cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708)
0.9 29.9 GO:0035371 microtubule plus-end(GO:0035371)
0.2 27.7 GO:0016607 nuclear speck(GO:0016607)
2.3 25.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 25.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 23.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 23.1 GO:0045202 synapse(GO:0045202)
1.1 22.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.8 20.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.3 19.1 GO:0031045 dense core granule(GO:0031045)
0.5 18.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 18.8 GO:0016021 integral component of membrane(GO:0016021)
0.1 16.8 GO:0005769 early endosome(GO:0005769)
1.2 15.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.0 15.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 14.7 GO:0031225 anchored component of membrane(GO:0031225)
0.6 14.1 GO:0031430 M band(GO:0031430)
1.5 13.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 54.9 GO:0008270 zinc ion binding(GO:0008270)
1.0 46.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
6.4 38.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 32.2 GO:0008017 microtubule binding(GO:0008017)
1.0 25.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.5 21.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
2.4 19.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
6.1 18.4 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
1.0 18.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.5 17.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.1 17.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.6 17.1 GO:0005112 Notch binding(GO:0005112)
0.9 14.9 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.6 14.7 GO:0032183 SUMO binding(GO:0032183)
0.5 14.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 14.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.7 13.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 13.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.3 13.4 GO:0005246 calcium channel regulator activity(GO:0005246)
2.7 13.3 GO:0086080 connexin binding(GO:0071253) protein binding involved in heterotypic cell-cell adhesion(GO:0086080)