Motif ID: Rfx3_Rfx1_Rfx4
Z-value: 2.468
Transcription factors associated with Rfx3_Rfx1_Rfx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rfx1 | ENSMUSG00000031706.6 | Rfx1 |
| Rfx3 | ENSMUSG00000040929.10 | Rfx3 |
| Rfx4 | ENSMUSG00000020037.9 | Rfx4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx4 | mm10_v2_chr10_+_84756055_84756084 | -0.59 | 7.3e-08 | Click! |
| Rfx3 | mm10_v2_chr19_-_28010995_28011054 | 0.17 | 1.6e-01 | Click! |
| Rfx1 | mm10_v2_chr8_+_84066824_84066882 | 0.04 | 7.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 26.8 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 5.3 | 21.4 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 3.5 | 10.4 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) endothelial cell-cell adhesion(GO:0071603) |
| 3.3 | 13.3 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 3.0 | 15.2 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
| 3.0 | 14.9 | GO:0032423 | regulation of mismatch repair(GO:0032423) |
| 3.0 | 8.9 | GO:2000834 | androgen secretion(GO:0035935) testosterone secretion(GO:0035936) negative regulation of glucagon secretion(GO:0070093) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
| 2.9 | 14.7 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 2.4 | 12.1 | GO:0021508 | floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505) |
| 2.3 | 46.2 | GO:0016486 | response to dietary excess(GO:0002021) peptide hormone processing(GO:0016486) |
| 2.1 | 27.9 | GO:0097688 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 2.0 | 6.1 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 1.8 | 40.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 1.8 | 12.7 | GO:0002437 | inflammatory response to antigenic stimulus(GO:0002437) |
| 1.6 | 9.7 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 1.6 | 6.3 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 1.6 | 14.1 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.6 | 25.1 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 1.4 | 4.3 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 1.4 | 5.6 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 1.4 | 8.2 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.4 | 5.4 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 1.3 | 8.0 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 1.3 | 6.6 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
| 1.3 | 7.6 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 1.2 | 3.5 | GO:0045014 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
| 1.1 | 3.3 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 1.1 | 11.7 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 1.1 | 7.4 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 1.1 | 21.2 | GO:0071625 | vocalization behavior(GO:0071625) |
| 1.0 | 5.9 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 1.0 | 2.9 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.9 | 5.7 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.9 | 2.8 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.9 | 8.2 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.9 | 23.4 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.9 | 3.4 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
| 0.8 | 10.2 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.8 | 1.7 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.8 | 2.5 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.8 | 2.4 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.8 | 4.5 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.7 | 11.2 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.7 | 3.7 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 0.7 | 4.4 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.7 | 2.2 | GO:1903546 | protein localization to photoreceptor outer segment(GO:1903546) |
| 0.7 | 17.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.7 | 14.6 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.7 | 7.6 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.7 | 23.1 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.7 | 2.0 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.6 | 3.8 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.6 | 7.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.6 | 5.5 | GO:0046626 | regulation of insulin receptor signaling pathway(GO:0046626) |
| 0.6 | 6.6 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.6 | 8.4 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.6 | 1.8 | GO:0036216 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) |
| 0.6 | 2.4 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.6 | 1.7 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
| 0.6 | 1.7 | GO:0030862 | regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862) |
| 0.6 | 1.7 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.5 | 1.6 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.5 | 2.1 | GO:0032439 | endosome localization(GO:0032439) Golgi to lysosome transport(GO:0090160) |
| 0.5 | 6.4 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.5 | 4.0 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.5 | 1.5 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
| 0.5 | 0.5 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.5 | 2.9 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.5 | 2.4 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.5 | 3.9 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.5 | 7.1 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.5 | 2.3 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.5 | 1.4 | GO:0090285 | regulation of protein glycosylation in Golgi(GO:0090283) negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.5 | 2.3 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.5 | 1.8 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.5 | 0.5 | GO:0032700 | negative regulation of interleukin-17 production(GO:0032700) |
| 0.4 | 2.6 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
| 0.4 | 38.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.4 | 12.2 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.4 | 4.0 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 0.4 | 17.2 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.4 | 1.2 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) phosphate ion transmembrane transport(GO:0035435) |
| 0.4 | 5.2 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.4 | 4.0 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473) |
| 0.4 | 5.9 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.4 | 1.1 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
| 0.4 | 1.1 | GO:0052490 | suppression by virus of host apoptotic process(GO:0019050) negative regulation by symbiont of host apoptotic process(GO:0033668) modulation by virus of host apoptotic process(GO:0039526) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490) |
| 0.4 | 8.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.4 | 4.1 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.4 | 1.1 | GO:1904742 | protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742) |
| 0.4 | 3.2 | GO:0061051 | positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051) |
| 0.4 | 1.4 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.4 | 2.8 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.3 | 1.0 | GO:0070649 | formin-nucleated actin cable assembly(GO:0070649) |
| 0.3 | 6.9 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.3 | 13.1 | GO:0045687 | positive regulation of glial cell differentiation(GO:0045687) |
| 0.3 | 3.0 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.3 | 1.0 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.3 | 4.9 | GO:0046321 | positive regulation of fatty acid oxidation(GO:0046321) |
| 0.3 | 1.0 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.3 | 1.6 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.3 | 2.3 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.3 | 11.0 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.3 | 3.0 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.3 | 4.2 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.3 | 7.0 | GO:2000171 | negative regulation of dendrite development(GO:2000171) |
| 0.3 | 25.9 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.3 | 0.6 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.3 | 1.7 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.3 | 1.1 | GO:0090148 | membrane fission(GO:0090148) |
| 0.3 | 2.2 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.3 | 6.5 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.3 | 0.3 | GO:2000646 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) positive regulation of receptor catabolic process(GO:2000646) |
| 0.3 | 0.8 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 0.3 | 16.4 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.3 | 0.5 | GO:1902953 | positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) |
| 0.3 | 3.6 | GO:0010388 | protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388) |
| 0.2 | 1.2 | GO:2001286 | regulation of caveolin-mediated endocytosis(GO:2001286) |
| 0.2 | 0.7 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.2 | 0.9 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.2 | 1.6 | GO:0061092 | involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.2 | 0.9 | GO:0006624 | vacuolar protein processing(GO:0006624) late endosome to lysosome transport(GO:1902774) negative regulation of vacuolar transport(GO:1903336) |
| 0.2 | 0.9 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.2 | 0.9 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
| 0.2 | 3.8 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.2 | 1.0 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.2 | 1.8 | GO:0021678 | third ventricle development(GO:0021678) |
| 0.2 | 1.0 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.2 | 2.7 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.2 | 3.0 | GO:0097484 | dendrite extension(GO:0097484) |
| 0.2 | 1.0 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.2 | 1.5 | GO:0006532 | aspartate biosynthetic process(GO:0006532) |
| 0.2 | 4.4 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.2 | 1.6 | GO:2001223 | negative regulation of neuron migration(GO:2001223) |
| 0.2 | 0.7 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.2 | 8.7 | GO:0035904 | aorta development(GO:0035904) |
| 0.2 | 4.1 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.2 | 2.6 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.1 | 3.2 | GO:0060043 | regulation of cardiac muscle cell proliferation(GO:0060043) |
| 0.1 | 3.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.9 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817) |
| 0.1 | 0.8 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.1 | 0.6 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 1.7 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 0.5 | GO:0048318 | axial mesoderm development(GO:0048318) |
| 0.1 | 1.0 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.5 | GO:0009597 | detection of virus(GO:0009597) positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) |
| 0.1 | 0.8 | GO:0045217 | cell-cell junction maintenance(GO:0045217) |
| 0.1 | 8.4 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.1 | 1.0 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.1 | 1.5 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.1 | 0.7 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.1 | 1.0 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.1 | 6.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.1 | 11.3 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.1 | 0.4 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.1 | 0.3 | GO:0006788 | heme oxidation(GO:0006788) |
| 0.1 | 0.3 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 6.1 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 0.5 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 0.5 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.1 | 2.8 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 1.8 | GO:0032402 | establishment of melanosome localization(GO:0032401) melanosome transport(GO:0032402) |
| 0.1 | 2.9 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
| 0.1 | 1.6 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 0.4 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 5.2 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.1 | 2.3 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.1 | 0.7 | GO:0015862 | uridine transport(GO:0015862) |
| 0.1 | 4.6 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.1 | 1.5 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.1 | 10.1 | GO:0030509 | BMP signaling pathway(GO:0030509) |
| 0.1 | 2.5 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis(GO:0032469) |
| 0.1 | 1.0 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 1.5 | GO:0001553 | luteinization(GO:0001553) |
| 0.1 | 0.8 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 0.7 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 0.3 | GO:0043312 | neutrophil degranulation(GO:0043312) |
| 0.1 | 0.3 | GO:0036451 | cap mRNA methylation(GO:0036451) |
| 0.1 | 0.4 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.1 | 0.6 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 0.1 | 0.1 | GO:1903525 | regulation of membrane tubulation(GO:1903525) |
| 0.1 | 1.9 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.1 | 2.6 | GO:0045453 | bone resorption(GO:0045453) |
| 0.1 | 1.3 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.1 | 6.2 | GO:0007631 | feeding behavior(GO:0007631) |
| 0.1 | 0.9 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.1 | 1.6 | GO:0060438 | trachea development(GO:0060438) |
| 0.1 | 0.7 | GO:0045019 | negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of nitric oxide metabolic process(GO:1904406) |
| 0.1 | 0.8 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) |
| 0.1 | 0.9 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.1 | 0.3 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.1 | 0.9 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 0.6 | GO:0046036 | CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
| 0.1 | 0.6 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606) |
| 0.1 | 1.1 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.1 | 1.0 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.2 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.1 | 0.2 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.1 | 0.4 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.1 | 8.7 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.1 | 0.4 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.1 | 0.3 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 0.6 | GO:0071470 | cellular response to osmotic stress(GO:0071470) |
| 0.1 | 0.2 | GO:0070278 | extracellular matrix constituent secretion(GO:0070278) |
| 0.1 | 2.0 | GO:0072527 | pyrimidine-containing compound metabolic process(GO:0072527) |
| 0.0 | 0.2 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.0 | 0.4 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 1.0 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 2.1 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.0 | 0.7 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.0 | 1.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.8 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 0.4 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.0 | 0.5 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.0 | 0.1 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.0 | 0.2 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.0 | 0.2 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.0 | 1.3 | GO:0051220 | cytoplasmic sequestering of protein(GO:0051220) |
| 0.0 | 0.1 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627) |
| 0.0 | 0.4 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 1.4 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.0 | 0.3 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.3 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.0 | 0.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.0 | 0.6 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 1.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.4 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.0 | 0.2 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) |
| 0.0 | 0.3 | GO:0001504 | neurotransmitter uptake(GO:0001504) |
| 0.0 | 0.5 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 1.9 | GO:0007613 | memory(GO:0007613) |
| 0.0 | 2.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.6 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.0 | 1.9 | GO:0090090 | negative regulation of canonical Wnt signaling pathway(GO:0090090) |
| 0.0 | 0.7 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.0 | 0.2 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
| 0.0 | 1.5 | GO:0050807 | regulation of synapse organization(GO:0050807) |
| 0.0 | 1.1 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 0.2 | GO:0071028 | nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028) |
| 0.0 | 0.2 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.0 | 0.5 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.0 | 0.1 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.0 | 0.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 1.8 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.8 | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus(GO:0035773) |
| 0.0 | 0.9 | GO:0046488 | phosphatidylinositol metabolic process(GO:0046488) |
| 0.0 | 0.1 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.0 | 0.4 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.9 | GO:0050905 | neuromuscular process(GO:0050905) |
| 0.0 | 1.8 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.5 | GO:0050709 | negative regulation of protein secretion(GO:0050709) |
| 0.0 | 0.4 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 0.5 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.0 | 1.9 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 25.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 2.0 | 5.9 | GO:0016939 | kinesin II complex(GO:0016939) |
| 1.6 | 9.5 | GO:0000235 | astral microtubule(GO:0000235) |
| 1.5 | 13.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 1.4 | 4.2 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 1.3 | 19.1 | GO:0031045 | dense core granule(GO:0031045) |
| 1.2 | 6.1 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 1.2 | 15.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 1.1 | 22.6 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 1.0 | 15.1 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 1.0 | 1.0 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.9 | 29.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.8 | 2.4 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.8 | 20.6 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.7 | 8.0 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.7 | 7.6 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.7 | 13.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.6 | 6.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.6 | 8.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.6 | 14.1 | GO:0031430 | M band(GO:0031430) |
| 0.5 | 18.8 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.5 | 2.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.5 | 4.1 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.4 | 10.4 | GO:0005921 | gap junction(GO:0005921) |
| 0.4 | 2.1 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.4 | 6.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.4 | 5.1 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.4 | 5.4 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.4 | 38.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.4 | 4.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.4 | 1.1 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.3 | 3.5 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.3 | 1.7 | GO:1990745 | EARP complex(GO:1990745) |
| 0.3 | 1.3 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.3 | 6.2 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.3 | 3.8 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.3 | 8.5 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.3 | 1.1 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.3 | 8.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.2 | 54.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 8.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.2 | 2.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.2 | 11.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 7.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.2 | 1.8 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.2 | 9.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 0.9 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.2 | 6.8 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.2 | 0.6 | GO:0055087 | Ski complex(GO:0055087) |
| 0.2 | 1.0 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.2 | 27.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 4.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 6.4 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.2 | 2.4 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.2 | 4.1 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.2 | 2.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.2 | 8.1 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 6.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.9 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.1 | 0.9 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.1 | 0.2 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.1 | 14.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.4 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 0.9 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.5 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.1 | 0.7 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.1 | 5.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 5.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 1.2 | GO:0044447 | axoneme part(GO:0044447) |
| 0.1 | 16.8 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 1.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.9 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 23.8 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 4.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.8 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 3.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 1.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 2.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 1.0 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 7.4 | GO:0043679 | axon terminus(GO:0043679) |
| 0.1 | 0.4 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 1.1 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 4.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 0.9 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.1 | 0.9 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 0.5 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 10.1 | GO:0031968 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
| 0.1 | 34.4 | GO:0097708 | cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708) |
| 0.1 | 1.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 5.7 | GO:0030017 | sarcomere(GO:0030017) |
| 0.1 | 7.9 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 23.1 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 6.8 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 0.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.1 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 1.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 1.1 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 0.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 1.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 3.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 2.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 1.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 25.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 0.2 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.1 | GO:0031251 | PAN complex(GO:0031251) |
| 0.0 | 2.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 10.1 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 5.2 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.8 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 18.8 | GO:0016021 | integral component of membrane(GO:0016021) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 38.6 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 6.1 | 18.4 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 2.7 | 13.3 | GO:0086080 | connexin binding(GO:0071253) protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 2.4 | 9.7 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 2.4 | 19.2 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 2.2 | 8.8 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 2.0 | 8.0 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 2.0 | 8.0 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 1.7 | 13.7 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 1.7 | 5.1 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 1.6 | 13.2 | GO:0001618 | virus receptor activity(GO:0001618) |
| 1.6 | 9.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 1.4 | 5.4 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.3 | 9.0 | GO:0034452 | dynactin binding(GO:0034452) |
| 1.1 | 17.2 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 1.1 | 4.4 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 1.1 | 4.3 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
| 1.0 | 25.1 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 1.0 | 46.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.0 | 18.2 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.9 | 14.9 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 0.9 | 11.4 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.9 | 4.3 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.8 | 10.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.8 | 2.4 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.7 | 3.6 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.6 | 14.7 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.6 | 17.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.6 | 5.6 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.5 | 1.6 | GO:0070137 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.5 | 5.7 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.5 | 2.6 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.5 | 4.1 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.5 | 21.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.5 | 7.0 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.5 | 1.5 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.5 | 17.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.5 | 8.4 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.5 | 14.1 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 6.2 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.5 | 8.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.5 | 1.4 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 0.4 | 0.9 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.4 | 1.3 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.4 | 12.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.4 | 2.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.4 | 8.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.4 | 8.3 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.4 | 3.8 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.3 | 1.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.3 | 1.4 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.3 | 2.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.3 | 4.8 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.3 | 4.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 8.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 2.2 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.3 | 6.8 | GO:0042171 | lysophosphatidic acid acyltransferase activity(GO:0042171) |
| 0.3 | 3.1 | GO:0052872 | 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014) |
| 0.3 | 2.5 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.3 | 13.7 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.3 | 2.4 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.3 | 2.8 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.3 | 13.4 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.3 | 0.8 | GO:0005119 | smoothened binding(GO:0005119) |
| 0.3 | 9.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.3 | 0.8 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.3 | 14.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.3 | 10.2 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) NADPH:sulfur oxidoreductase activity(GO:0043914) epoxyqueuosine reductase activity(GO:0052693) |
| 0.2 | 1.0 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
| 0.2 | 2.0 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.2 | 0.7 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.2 | 8.7 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.2 | 4.3 | GO:0050253 | prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032) |
| 0.2 | 2.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.2 | 8.8 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.2 | 0.9 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.2 | 8.5 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.2 | 0.9 | GO:0038025 | reelin receptor activity(GO:0038025) |
| 0.2 | 3.8 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.2 | 0.8 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.2 | 7.1 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.2 | 3.8 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.2 | 0.6 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.2 | 6.1 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.2 | 0.5 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) U7 snRNA binding(GO:0071209) |
| 0.2 | 0.7 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.2 | 0.4 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.2 | 2.1 | GO:0008796 | bis(5'-nucleosyl)-tetraphosphatase activity(GO:0008796) |
| 0.2 | 1.2 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.2 | 4.9 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.2 | 2.3 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.2 | 8.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 3.4 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
| 0.2 | 2.7 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.2 | 6.8 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.2 | 1.2 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 2.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 1.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 9.4 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.1 | 1.0 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.1 | 1.3 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.1 | 1.0 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 0.8 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.1 | 1.6 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 4.2 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 1.6 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 7.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 32.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 3.3 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) |
| 0.1 | 1.8 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 3.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 0.8 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 11.4 | GO:0008026 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
| 0.1 | 4.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 0.9 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.9 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 1.1 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 1.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 0.7 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) |
| 0.1 | 0.6 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.1 | 1.8 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 0.3 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.1 | 0.3 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 11.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 5.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 1.0 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.1 | 7.5 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.1 | 1.6 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 1.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 1.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.1 | 4.2 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.1 | 4.1 | GO:0043774 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) |
| 0.1 | 2.2 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 0.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 0.6 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 0.6 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.1 | GO:0036004 | GAF domain binding(GO:0036004) |
| 0.1 | 1.5 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 3.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 0.8 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 54.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 0.1 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
| 0.0 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 4.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.6 | GO:0030170 | pyridoxal phosphate binding(GO:0030170) |
| 0.0 | 0.1 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.0 | 0.3 | GO:0008905 | mannose-phosphate guanylyltransferase activity(GO:0008905) |
| 0.0 | 0.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 0.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 1.1 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 2.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.7 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 0.1 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.2 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.0 | 1.0 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.5 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 1.3 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 1.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.2 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.7 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.5 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 1.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 1.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
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