Motif ID: Rfx5

Z-value: 0.633


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.066.5e-01Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_37376359 5.985 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr7_-_105752193 5.396 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr17_+_34263209 5.172 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr7_-_30664986 5.012 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr17_+_35861318 4.590 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr7_-_45092130 4.218 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_+_35861343 3.988 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr7_+_46841475 3.958 ENSMUST00000147535.1
 Ldha
lactate dehydrogenase A
chr8_+_94214567 3.688 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr7_-_45091713 3.668 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr11_-_3539228 3.382 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr5_+_139150211 3.303 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr1_-_183147461 3.072 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr11_+_61505138 3.041 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr2_+_122147680 2.998 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr17_+_37270214 2.728 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr17_+_35379608 2.583 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr7_+_100537192 2.567 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr17_+_35439155 2.567 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr7_+_100537052 2.436 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr5_-_36830647 2.302 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr4_-_116627921 2.058 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr11_+_117523526 1.997 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr11_+_98682554 1.778 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr13_+_24831661 1.681 ENSMUST00000038039.2
 Tdp2
tyrosyl-DNA phosphodiesterase 2
chr8_-_69996326 1.677 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr18_-_51865881 1.519 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950
chr10_-_19011948 1.457 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr7_+_101378183 1.431 ENSMUST00000084895.5
 Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr12_+_108334341 1.387 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr17_+_34305883 1.319 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr17_-_24886304 1.284 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr5_-_125294107 1.228 ENSMUST00000127148.1
 Scarb1
scavenger receptor class B, member 1
chr3_-_95882193 1.053 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr11_+_72441341 1.046 ENSMUST00000045633.5
 Mybbp1a
MYB binding protein (P160) 1a
chr19_-_10482874 1.037 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chrX_-_160138375 0.940 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr7_-_19692596 0.926 ENSMUST00000108451.2
ENSMUST00000045035.4
 Apoc1

apolipoprotein C-I

chr2_-_128687354 0.915 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
 Anapc1


anaphase promoting complex subunit 1


chr8_+_84969587 0.912 ENSMUST00000109734.1
ENSMUST00000005292.8
 Prdx2

peroxiredoxin 2

chr6_-_8259098 0.898 ENSMUST00000012627.4
 Rpa3
replication protein A3
chr3_-_95882031 0.855 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr10_-_7663245 0.832 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr8_-_89187560 0.738 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr17_-_34187219 0.693 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr19_-_4615647 0.690 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr2_-_152398046 0.626 ENSMUST00000063332.8
ENSMUST00000182625.1
 Sox12

SRY-box containing gene 12

chr1_+_136676413 0.515 ENSMUST00000181491.1
 Gm19705
predicted gene, 19705
chr3_-_95882232 0.493 ENSMUST00000161866.1
 Gm129
predicted gene 129
chr7_+_44468020 0.490 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr4_+_107968332 0.456 ENSMUST00000106713.3
 Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr7_-_101921186 0.440 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr6_-_29165003 0.427 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr10_-_7663569 0.420 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr7_-_101921175 0.315 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr7_+_44467980 0.278 ENSMUST00000035844.4
 Josd2
Josephin domain containing 2
chr3_+_16183177 0.207 ENSMUST00000108345.2
ENSMUST00000108346.2
 Ythdf3

YTH domain family 3

chr9_+_44773191 0.169 ENSMUST00000147559.1
 Ift46
intraflagellar transport 46
chr19_+_32757497 0.134 ENSMUST00000013807.7
 Pten
phosphatase and tensin homolog
chr7_+_44468051 0.091 ENSMUST00000118493.1
 Josd2
Josephin domain containing 2
chr9_-_51102062 0.015 ENSMUST00000170947.1
 4833427G06Rik
RIKEN cDNA 4833427G06 gene
chr6_+_94500313 0.008 ENSMUST00000061118.8
 Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0002339 B cell selection(GO:0002339)
1.0 6.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.9 2.7 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.8 4.0 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.6 3.0 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.5 1.5 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.5 5.0 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.4 1.7 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.4 1.2 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.3 2.3 GO:0006013 mannose metabolic process(GO:0006013)
0.3 3.1 GO:0060539 diaphragm development(GO:0060539)
0.3 3.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 5.4 GO:0043171 peptide catabolic process(GO:0043171)
0.2 1.0 GO:2000210 positive regulation of anoikis(GO:2000210)
0.2 1.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.9 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.1 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.1 0.9 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 2.1 GO:0043486 histone exchange(GO:0043486)
0.1 3.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 1.3 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.1 5.0 GO:0051225 spindle assembly(GO:0051225)
0.0 1.4 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 3.0 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.9 GO:0006298 mismatch repair(GO:0006298)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.7 GO:2000116 regulation of cysteine-type endopeptidase activity(GO:2000116)
0.0 1.3 GO:0034341 response to interferon-gamma(GO:0034341)
0.0 0.9 GO:0006641 triglyceride metabolic process(GO:0006641)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.2 GO:0042611 MHC protein complex(GO:0042611)
0.6 5.0 GO:0070652 HAUS complex(GO:0070652)
0.5 8.6 GO:0005652 nuclear lamina(GO:0005652)
0.3 1.0 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 4.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 3.0 GO:0036038 MKS complex(GO:0036038)
0.1 0.9 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 6.0 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.9 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 5.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.9 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 3.7 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 9.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.0 3.0 GO:0008158 hedgehog receptor activity(GO:0008158)
1.0 4.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.6 5.2 GO:0015643 toxic substance binding(GO:0015643)
0.4 1.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 5.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.3 1.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 2.3 GO:0042605 peptide antigen binding(GO:0042605)
0.2 3.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 0.9 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 2.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.6 GO:0015197 peptide transporter activity(GO:0015197)
0.1 2.3 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.1 1.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 2.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 1.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.7 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 3.0 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 7.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)