Motif ID: Rreb1

Z-value: 0.966


Transcription factors associated with Rreb1:

Gene SymbolEntrez IDGene Name
Rreb1 ENSMUSG00000039087.10 Rreb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1mm10_v2_chr13_+_37826225_37826315-0.094.5e-01Click!


Activity profile for motif Rreb1.

activity profile for motif Rreb1


Sorted Z-values histogram for motif Rreb1

Sorted Z-values for motif Rreb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rreb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7919816 9.464 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_+_67586520 8.519 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_67586675 7.604 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr15_+_83791939 7.477 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr13_+_43615710 7.474 ENSMUST00000059986.2
 Rnf182
ring finger protein 182
chr3_+_55461758 6.643 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr16_-_67620880 6.317 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr3_+_96181151 6.316 ENSMUST00000035371.8
 Sv2a
synaptic vesicle glycoprotein 2 a
chr8_+_57455898 6.178 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr3_-_89245159 6.115 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr7_+_5056856 5.990 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chr5_+_37047464 5.954 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr14_-_34201604 5.899 ENSMUST00000096019.2
 Gprin2
G protein regulated inducer of neurite outgrowth 2
chr2_-_33371486 5.896 ENSMUST00000113165.1
 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr12_+_29528382 5.754 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr13_+_109632760 5.580 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr16_-_67620805 5.537 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr3_-_73056943 5.524 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr17_+_35076902 5.500 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr7_+_5056706 5.437 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 GO:0051017 actin filament bundle assembly(GO:0051017)
0.6 11.0 GO:0002021 response to dietary excess(GO:0002021)
2.1 10.7 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.2 9.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 9.7 GO:0006836 neurotransmitter transport(GO:0006836)
1.9 9.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.3 7.8 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 7.7 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.3 7.6 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.1 7.1 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 6.9 GO:0016567 protein ubiquitination(GO:0016567)
0.2 6.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 6.4 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
2.0 6.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 6.0 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
1.2 5.8 GO:0046684 response to pyrethroid(GO:0046684)
1.1 5.7 GO:0034436 glycoprotein transport(GO:0034436)
0.7 5.6 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
1.1 4.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.9 4.3 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 13.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 12.8 GO:0005884 actin filament(GO:0005884)
0.2 11.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 9.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 8.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 7.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 6.2 GO:0044306 neuron projection terminus(GO:0044306)
0.6 6.0 GO:0044327 dendritic spine head(GO:0044327)
0.0 6.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.4 5.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.4 5.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 5.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 4.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 4.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.4 4.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 4.2 GO:0030141 secretory granule(GO:0030141)
0.3 4.1 GO:0032279 asymmetric synapse(GO:0032279)
0.8 4.0 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 4.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 4.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 GO:0051015 actin filament binding(GO:0051015)
1.8 10.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 9.3 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.3 9.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 9.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.3 8.8 GO:0070412 R-SMAD binding(GO:0070412)
2.5 7.6 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.1 7.5 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 6.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
1.0 6.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.3 6.5 GO:0031402 sodium ion binding(GO:0031402)
0.3 6.0 GO:0050811 GABA receptor binding(GO:0050811)
0.0 5.9 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 5.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.9 5.7 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)
0.1 5.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2 5.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.8 4.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 4.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 4.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)