Motif ID: Runx1

Z-value: 0.772


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 16.319 ENSMUST00000168589.1
Sla
src-like adaptor
chr17_+_3397189 11.209 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr2_+_37516618 8.112 ENSMUST00000065441.6
Gpr21
G protein-coupled receptor 21
chr13_+_76579670 5.115 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1

multiple C2 domains, transmembrane 1

chr1_-_169747634 4.775 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chrX_+_159697308 4.594 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr4_+_102760294 4.589 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr16_+_42907563 4.498 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr12_-_25096080 4.490 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr17_-_90455872 3.996 ENSMUST00000174337.1
ENSMUST00000172466.1
Nrxn1

neurexin I

chr2_-_52558539 3.962 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr10_+_69925954 3.945 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
Ank3


ankyrin 3, epithelial


chr4_-_14621805 3.919 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr17_+_35236556 3.881 ENSMUST00000068261.8
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr3_+_96181151 3.833 ENSMUST00000035371.8
Sv2a
synaptic vesicle glycoprotein 2 a
chr14_-_124677089 3.777 ENSMUST00000095529.3
Fgf14
fibroblast growth factor 14
chr15_-_76090013 3.679 ENSMUST00000019516.4
Nrbp2
nuclear receptor binding protein 2
chr9_+_113812547 3.448 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr2_+_32629467 3.126 ENSMUST00000068271.4
Ak1
adenylate kinase 1
chr8_+_105690906 3.020 ENSMUST00000062574.6
Rltpr
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.4 8.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
1.1 7.4 GO:0019532 oxalate transport(GO:0019532)
0.2 6.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 5.8 GO:0015807 L-amino acid transport(GO:0015807)
0.8 5.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 4.8 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 4.8 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.2 4.6 GO:0097320 membrane tubulation(GO:0097320)
0.9 4.5 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.8 4.0 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.6 4.0 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.4 3.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.8 3.8 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 3.8 GO:0006836 neurotransmitter transport(GO:0006836)
0.6 3.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 3.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 3.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
1.0 3.0 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
0.0 3.0 GO:0015992 proton transport(GO:0015992)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.4 GO:0005829 cytosol(GO:0005829)
0.0 9.3 GO:0005768 endosome(GO:0005768)
0.0 7.7 GO:0000785 chromatin(GO:0000785)
0.0 5.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 4.9 GO:0072562 blood microparticle(GO:0072562)
0.4 4.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 4.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 4.0 GO:0042734 presynaptic membrane(GO:0042734)
0.4 3.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 3.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 3.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.6 GO:0030139 endocytic vesicle(GO:0030139)
1.1 3.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 3.1 GO:0001520 outer dense fiber(GO:0001520)
0.3 3.0 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 2.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.4 GO:0043235 receptor complex(GO:0043235)
0.0 2.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.1 GO:0045177 apical part of cell(GO:0045177)
0.6 1.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 9.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.7 8.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.7 7.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 7.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 6.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 5.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.7 5.0 GO:0001851 complement component C3b binding(GO:0001851)
0.2 4.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 4.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 4.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 4.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 4.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 3.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 3.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 3.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 3.4 GO:0044325 ion channel binding(GO:0044325)
0.0 3.3 GO:0008083 growth factor activity(GO:0008083)
0.3 3.1 GO:0004017 adenylate kinase activity(GO:0004017)