Motif ID: Runx2_Bcl11a

Z-value: 1.032

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24078173_24078219-0.161.8e-01Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 11.992 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr8_-_11008458 6.478 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr15_-_66801577 5.844 ENSMUST00000168589.1
 Sla
src-like adaptor
chr4_-_136892867 5.244 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr11_-_83649349 5.218 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr19_+_3935186 4.939 ENSMUST00000162708.1
ENSMUST00000165711.1
 Unc93b1

unc-93 homolog B1 (C. elegans)

chr4_+_144892813 4.888 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_+_58210397 4.731 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr11_+_101246960 4.547 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr1_-_140183404 4.403 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr3_-_87263518 4.329 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr15_+_3270767 4.131 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr15_-_37459327 4.063 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr11_-_106388066 4.034 ENSMUST00000106813.2
ENSMUST00000141146.1
 Icam2

intercellular adhesion molecule 2

chr5_-_77408034 4.000 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chr5_+_90772435 3.952 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr1_-_172297989 3.542 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr11_+_105975204 3.469 ENSMUST00000001964.7
 Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr9_-_103219823 3.254 ENSMUST00000168142.1
 Trf
transferrin
chr1_+_169655493 3.233 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 273 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.4 GO:0042572 retinol metabolic process(GO:0042572)
1.1 6.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.7 6.3 GO:0043615 astrocyte cell migration(GO:0043615)
0.7 6.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.9 6.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 5.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 5.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.7 5.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.1 5.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.6 4.9 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
1.6 4.7 GO:0046110 xanthine metabolic process(GO:0046110)
0.7 4.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.5 4.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.6 4.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.8 4.0 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
1.3 3.8 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.8 3.8 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
1.2 3.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
1.2 3.5 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
1.1 3.4 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.0 GO:0005615 extracellular space(GO:0005615)
0.2 15.8 GO:0072562 blood microparticle(GO:0072562)
0.1 12.4 GO:0016323 basolateral plasma membrane(GO:0016323)
3.0 12.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 8.0 GO:0043235 receptor complex(GO:0043235)
0.0 6.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.8 6.1 GO:0032009 early phagosome(GO:0032009)
0.1 4.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4 4.3 GO:0031091 platelet alpha granule(GO:0031091)
0.4 4.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.4 3.3 GO:0097433 dense body(GO:0097433)
0.2 3.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 3.0 GO:0031012 extracellular matrix(GO:0031012)
0.4 2.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.7 2.8 GO:0001533 cornified envelope(GO:0001533)
0.1 2.8 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 2.5 GO:0031430 M band(GO:0031430)
0.5 2.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 2.2 GO:0097228 sperm principal piece(GO:0097228)
0.1 2.2 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 12.0 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.3 9.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 7.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
2.2 6.6 GO:0001851 complement component C3b binding(GO:0001851)
0.2 6.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 6.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 5.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 5.3 GO:0008083 growth factor activity(GO:0008083)
1.6 4.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.2 4.7 GO:0030151 molybdenum ion binding(GO:0030151)
0.5 4.7 GO:0035325 Toll-like receptor binding(GO:0035325)
0.3 4.5 GO:0015026 coreceptor activity(GO:0015026)
0.2 4.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 4.2 GO:0050811 GABA receptor binding(GO:0050811)
0.3 4.1 GO:0008430 selenium binding(GO:0008430)
0.2 4.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
1.3 4.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.9 3.5 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573)
0.4 3.5 GO:1990239 steroid hormone binding(GO:1990239)
1.1 3.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)