Motif ID: Runx3

Z-value: 0.589


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 77 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_20181773 7.416 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr2_-_71546745 5.079 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr13_-_22041352 4.831 ENSMUST00000102977.2
Hist1h4i
histone cluster 1, H4i
chr19_-_36736653 4.364 ENSMUST00000087321.2
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr13_+_51645232 4.348 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr18_-_47368446 3.275 ENSMUST00000076043.6
ENSMUST00000135790.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr3_-_154330543 3.186 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr11_-_89302545 3.106 ENSMUST00000061728.3
Nog
noggin
chr2_+_72476159 3.089 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr2_+_72476225 3.071 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr13_-_23551648 2.885 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr17_+_27556668 2.584 ENSMUST00000117254.1
ENSMUST00000118570.1
Hmga1

high mobility group AT-hook 1

chr17_+_27556613 2.558 ENSMUST00000117600.1
ENSMUST00000114888.3
Hmga1

high mobility group AT-hook 1

chr17_+_27556641 2.511 ENSMUST00000119486.1
ENSMUST00000118599.1
Hmga1

high mobility group AT-hook 1

chrX_+_99136119 2.479 ENSMUST00000052839.6
Efnb1
ephrin B1
chr13_-_23698454 2.400 ENSMUST00000102967.1
Hist1h4c
histone cluster 1, H4c
chr13_-_21832194 2.134 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr2_+_145785980 2.134 ENSMUST00000110005.1
ENSMUST00000094480.4
Rin2

Ras and Rab interactor 2

chr7_-_78783026 1.751 ENSMUST00000032841.5
Mrpl46
mitochondrial ribosomal protein L46
chr11_-_5878207 1.707 ENSMUST00000102922.3
Pold2
polymerase (DNA directed), delta 2, regulatory subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 7.7 GO:0006284 base-excision repair(GO:0006284)
1.7 5.1 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 4.3 GO:0007127 meiosis I(GO:0007127)
0.2 3.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 3.2 GO:0021884 forebrain neuron development(GO:0021884)
0.8 3.1 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 3.1 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.3 2.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 2.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 2.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.8 GO:0060009 Sertoli cell development(GO:0060009)
0.6 1.7 GO:0014891 striated muscle atrophy(GO:0014891)
0.2 1.7 GO:1903689 regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.2 1.7 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 1.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.2 1.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 1.4 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.4 1.2 GO:0006083 acetate metabolic process(GO:0006083)
0.2 1.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.7 GO:0000786 nucleosome(GO:0000786)
1.1 7.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.5 4.4 GO:0042587 glycogen granule(GO:0042587)
0.5 3.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 2.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.6 1.7 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.6 1.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 1.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 1.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.2 GO:0045120 pronucleus(GO:0045120)
0.2 1.1 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.3 GO:0042393 histone binding(GO:0042393)
0.9 7.7 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 5.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 4.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 4.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 3.1 GO:0019955 cytokine binding(GO:0019955)
0.0 2.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 2.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 2.2 GO:0008201 heparin binding(GO:0008201)
0.6 1.7 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.4 1.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.4 GO:0008242 omega peptidase activity(GO:0008242)
0.1 1.4 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.4 1.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 1.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 1.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.1 GO:0004526 ribonuclease P activity(GO:0004526)