Motif ID: Sin3a

Z-value: 1.304


Transcription factors associated with Sin3a:

Gene SymbolEntrez IDGene Name
Sin3a ENSMUSG00000042557.8 Sin3a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sin3amm10_v2_chr9_+_57072024_570720480.191.2e-01Click!


Activity profile for motif Sin3a.

activity profile for motif Sin3a


Sorted Z-values histogram for motif Sin3a

Sorted Z-values for motif Sin3a



Network of associatons between targets according to the STRING database.



First level regulatory network of Sin3a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_69360294 12.378 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chr5_-_106458440 7.801 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr18_-_72351009 7.450 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr18_-_72351029 7.160 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chr18_+_64340225 6.929 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr6_-_39206782 6.871 ENSMUST00000002305.8
 Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr15_-_66286224 6.457 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr14_-_12823031 6.251 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
 Cadps



Ca2+-dependent secretion activator



chrX_-_104201099 5.187 ENSMUST00000087879.4
 C77370
expressed sequence C77370
chrX_-_104201126 5.155 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chrX_-_147554050 5.138 ENSMUST00000112819.2
ENSMUST00000136789.1
 Lrch2

leucine-rich repeats and calponin homology (CH) domain containing 2

chr15_-_78120011 4.933 ENSMUST00000019290.2
 Cacng2
calcium channel, voltage-dependent, gamma subunit 2
chr5_+_117413977 4.667 ENSMUST00000180430.1
 Ksr2
kinase suppressor of ras 2
chr2_-_153529941 4.642 ENSMUST00000035346.7
 8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr11_-_69369377 4.597 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr3_-_52104891 4.567 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr1_+_167001457 4.551 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr16_-_74411292 4.481 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr1_-_119837613 4.439 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr12_-_5375682 4.384 ENSMUST00000020958.8
 Klhl29
kelch-like 29

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 527 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 14.5 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.8 12.1 GO:0060081 membrane hyperpolarization(GO:0060081)
0.1 11.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.3 10.3 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.2 10.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.6 9.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 9.6 GO:0016082 synaptic vesicle priming(GO:0016082)
0.3 9.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
3.1 9.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 8.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.6 7.5 GO:0071286 cellular response to magnesium ion(GO:0071286)
1.5 7.4 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
1.2 6.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.5 6.9 GO:1990403 embryonic brain development(GO:1990403)
0.6 6.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 6.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.5 6.0 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.6 5.6 GO:0071420 cellular response to histamine(GO:0071420)
0.7 5.4 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.2 5.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 15.5 GO:0032584 growth cone membrane(GO:0032584)
0.5 15.2 GO:0030673 axolemma(GO:0030673)
0.5 14.9 GO:0043194 axon initial segment(GO:0043194)
1.3 12.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 11.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 10.0 GO:0016607 nuclear speck(GO:0016607)
0.2 9.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 9.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 9.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 8.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.4 7.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.6 7.8 GO:0030314 junctional membrane complex(GO:0030314)
0.0 7.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 6.8 GO:0043198 dendritic shaft(GO:0043198)
0.2 6.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 6.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 5.7 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 5.3 GO:0043204 perikaryon(GO:0043204)
0.1 5.2 GO:0072562 blood microparticle(GO:0072562)
0.1 5.1 GO:0060170 ciliary membrane(GO:0060170)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 303 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.6 15.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
2.5 15.3 GO:0005042 netrin receptor activity(GO:0005042)
0.1 14.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 14.5 GO:0045296 cadherin binding(GO:0045296)
1.7 13.6 GO:0002151 G-quadruplex RNA binding(GO:0002151)
1.7 11.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 11.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 10.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.4 9.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.4 9.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 9.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 9.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.6 9.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.0 8.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.9 8.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 7.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 7.5 GO:0008017 microtubule binding(GO:0008017)
0.0 7.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.6 7.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)