Motif ID: Six3_Six1_Six2

Z-value: 0.884

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85620816_856208430.694.0e-11Click!
Six2mm10_v2_chr17_-_85688252_856882750.581.8e-07Click!
Six1mm10_v2_chr12_-_73047179_730471790.474.7e-05Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 73 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_139454747 16.314 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr18_+_56432116 14.370 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_-_142966709 13.618 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_+_98422961 11.706 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr5_+_140607334 9.461 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_-_75894474 8.906 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr15_-_82244716 8.481 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr9_+_65141154 6.816 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr7_-_80115294 6.524 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr10_-_128180265 5.764 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_+_98571004 4.576 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr13_+_94083490 3.511 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr5_+_139423151 3.507 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr3_-_37724321 3.466 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr3_+_130068390 3.289 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr8_-_4275886 3.280 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr10_+_24595623 3.212 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr6_-_23248264 3.125 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_136467958 3.086 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr8_+_57455898 2.621 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.3 GO:0051661 maintenance of centrosome location(GO:0051661)
2.9 11.7 GO:0006776 vitamin A metabolic process(GO:0006776)
1.9 9.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 6.6 GO:0050885 neuromuscular process controlling balance(GO:0050885)
2.2 6.5 GO:0006097 glyoxylate cycle(GO:0006097)
0.7 4.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
1.2 3.5 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.2 3.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.8 3.2 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 3.2 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
1.0 3.1 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.5 3.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 3.0 GO:0032526 response to retinoic acid(GO:0032526)
0.2 2.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.8 2.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 2.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 1.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.4 1.7 GO:0060032 notochord regression(GO:0060032)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.6 GO:0035855 megakaryocyte development(GO:0035855)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.3 GO:0036449 microtubule minus-end(GO:0036449)
0.2 14.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 11.0 GO:0000776 kinetochore(GO:0000776)
0.0 11.0 GO:0044297 cell body(GO:0044297)
0.1 6.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 6.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 4.9 GO:0005688 U6 snRNP(GO:0005688)
0.4 3.5 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.0 3.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 3.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 3.1 GO:0051233 spindle midzone(GO:0051233)
0.3 2.6 GO:0061574 ASAP complex(GO:0061574)
0.0 2.6 GO:0044306 neuron projection terminus(GO:0044306)
0.8 2.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.7 GO:0097542 ciliary tip(GO:0097542)
0.1 1.6 GO:0031209 SCAR complex(GO:0031209)
0.1 1.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.3 GO:0001772 immunological synapse(GO:0001772)
0.1 1.2 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.3 GO:0005516 calmodulin binding(GO:0005516)
2.0 11.7 GO:0019841 retinol binding(GO:0019841)
3.2 9.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
2.2 6.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.0 4.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.6 3.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 3.3 GO:0051087 chaperone binding(GO:0051087)
0.1 3.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.8 3.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 2.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 2.0 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.9 GO:0030331 estrogen receptor binding(GO:0030331)
0.4 1.2 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 1.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0051537 ferrous iron binding(GO:0008198) 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 0.6 GO:0016206 catechol O-methyltransferase activity(GO:0016206)