Motif ID: Six3_Six1_Six2

Z-value: 0.884

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85620816_856208430.694.0e-11Click!
Six2mm10_v2_chr17_-_85688252_856882750.581.8e-07Click!
Six1mm10_v2_chr12_-_73047179_730471790.474.7e-05Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_139454747 16.314 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr18_+_56432116 14.370 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_-_142966709 13.618 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_+_98422961 11.706 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr5_+_140607334 9.461 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_-_75894474 8.906 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr15_-_82244716 8.481 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr9_+_65141154 6.816 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr7_-_80115294 6.524 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr10_-_128180265 5.764 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_+_98571004 4.576 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr13_+_94083490 3.511 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr5_+_139423151 3.507 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr3_-_37724321 3.466 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr3_+_130068390 3.289 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr8_-_4275886 3.280 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr10_+_24595623 3.212 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr6_-_23248264 3.125 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_136467958 3.086 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr8_+_57455898 2.621 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr13_+_104229366 2.556 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr17_+_35241838 2.503 ENSMUST00000173731.1
 Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr3_+_146220955 2.487 ENSMUST00000039164.2
 Lpar3
lysophosphatidic acid receptor 3
chr17_+_35241746 2.391 ENSMUST00000068056.5
ENSMUST00000174757.1
 Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr9_+_104002546 2.313 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chrX_+_169685191 2.127 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr9_+_72958785 1.928 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr14_+_57798182 1.904 ENSMUST00000111269.1
 Sap18
Sin3-associated polypeptide 18
chr1_-_118982551 1.710 ENSMUST00000159678.1
 Gli2
GLI-Kruppel family member GLI2
chr3_+_94398517 1.666 ENSMUST00000050975.3
 Lingo4
leucine rich repeat and Ig domain containing 4
chr2_-_13271268 1.659 ENSMUST00000137670.1
ENSMUST00000114791.2
 Rsu1

Ras suppressor protein 1

chrX_-_74373260 1.643 ENSMUST00000073067.4
ENSMUST00000037967.5
 Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr4_+_133176336 1.581 ENSMUST00000105912.1
 Wasf2
WAS protein family, member 2
chr2_-_13271419 1.548 ENSMUST00000028059.2
 Rsu1
Ras suppressor protein 1
chr15_-_76206309 1.433 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
 Plec


plectin


chrX_-_74373218 1.395 ENSMUST00000178691.1
ENSMUST00000114146.1
 Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr11_-_101987004 1.262 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr10_+_100488289 1.203 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr4_-_43030440 1.200 ENSMUST00000135660.1
 Stoml2
stomatin (Epb7.2)-like 2
chr19_-_55315980 1.142 ENSMUST00000076891.5
 Zdhhc6
zinc finger, DHHC domain containing 6
chr7_-_141168671 1.138 ENSMUST00000106033.3
 Rnh1
ribonuclease/angiogenin inhibitor 1
chr11_-_69695521 1.114 ENSMUST00000181261.1
 Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr5_+_21543525 1.112 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr5_-_62765618 1.093 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_121839460 1.000 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr3_+_88207308 0.981 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr8_+_69832633 0.943 ENSMUST00000131637.2
ENSMUST00000081503.6
 Pbx4

pre B cell leukemia homeobox 4

chr13_+_43785107 0.877 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr12_+_84773262 0.744 ENSMUST00000021667.5
 Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr8_-_106573461 0.739 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr12_+_30584429 0.728 ENSMUST00000057151.8
 Tmem18
transmembrane protein 18
chr14_+_57798156 0.704 ENSMUST00000128764.1
 Sap18
Sin3-associated polypeptide 18
chr7_-_101903783 0.642 ENSMUST00000106969.1
 Tomt
transmembrane O-methyltransferase
chr4_-_32950813 0.615 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr17_+_40811089 0.573 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr4_+_11758147 0.547 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr5_+_104046869 0.534 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr4_+_134864536 0.520 ENSMUST00000030627.7
 Rhd
Rh blood group, D antigen
chr2_+_131491764 0.489 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
 Smox






spermine oxidase






chr2_+_158028481 0.487 ENSMUST00000103123.3
 Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr6_+_38534823 0.453 ENSMUST00000019833.4
 1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr19_+_8764934 0.299 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chrY_-_6237995 0.268 ENSMUST00000177612.1
 Gm21746
predicted gene, 21746
chr7_+_30231884 0.254 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr7_-_126676428 0.243 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr11_-_99230998 0.241 ENSMUST00000103133.3
 Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr8_+_71951038 0.234 ENSMUST00000131237.1
ENSMUST00000136516.1
ENSMUST00000109997.2
ENSMUST00000132848.1
 Zfp961



zinc finger protein 961



chr1_-_119504736 0.225 ENSMUST00000004565.8
 Ralb
v-ral simian leukemia viral oncogene homolog B (ras related)
chr7_+_30232310 0.146 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr16_+_11203375 0.119 ENSMUST00000181526.1
 2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr16_-_11203259 0.085 ENSMUST00000119953.1
 Rsl1d1
ribosomal L1 domain containing 1
chr8_+_84831522 0.077 ENSMUST00000036734.5
 Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr13_-_74292297 0.005 ENSMUST00000109640.1
ENSMUST00000022059.7
 Ahrr

aryl-hydrocarbon receptor repressor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 16.3 GO:0051661 maintenance of centrosome location(GO:0051661)
2.9 11.7 GO:0006776 vitamin A metabolic process(GO:0006776)
2.2 6.5 GO:0006097 glyoxylate cycle(GO:0006097)
1.9 9.5 GO:0007386 compartment pattern specification(GO:0007386)
1.2 3.5 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
1.0 3.1 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.8 3.2 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.8 2.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.7 4.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.5 3.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 1.7 GO:0060032 notochord regression(GO:0060032)
0.4 1.2 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.4 1.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 1.1 GO:0048539 bone marrow development(GO:0048539)
0.2 3.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 1.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 1.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 2.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2 0.5 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 0.5 GO:0046032 ADP catabolic process(GO:0046032)
0.2 0.6 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 0.9 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 0.4 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.5 GO:0046208 spermine catabolic process(GO:0046208)
0.1 1.6 GO:0035855 megakaryocyte development(GO:0035855)
0.1 1.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 6.6 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.1 0.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 2.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.5 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 3.2 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 3.0 GO:0032526 response to retinoic acid(GO:0032526)
0.0 1.2 GO:0035058 nonmotile primary cilium assembly(GO:0035058)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.2 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 1.1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.2 GO:0051923 sulfation(GO:0051923)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 16.3 GO:0036449 microtubule minus-end(GO:0036449)
0.8 2.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.4 4.9 GO:0005688 U6 snRNP(GO:0005688)
0.4 1.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.4 3.5 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.3 2.6 GO:0061574 ASAP complex(GO:0061574)
0.2 14.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.7 GO:0097542 ciliary tip(GO:0097542)
0.1 1.6 GO:0031209 SCAR complex(GO:0031209)
0.1 6.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 3.1 GO:0051233 spindle midzone(GO:0051233)
0.1 1.2 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.1 11.0 GO:0000776 kinetochore(GO:0000776)
0.1 3.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.0 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.9 GO:0001741 XY body(GO:0001741)
0.0 1.3 GO:0001772 immunological synapse(GO:0001772)
0.0 6.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 2.6 GO:0044306 neuron projection terminus(GO:0044306)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 3.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 11.0 GO:0044297 cell body(GO:0044297)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
2.2 6.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.0 11.7 GO:0019841 retinol binding(GO:0019841)
1.0 4.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.8 3.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.6 3.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.4 2.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 1.2 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 0.6 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.2 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 0.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.2 0.5 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.2 1.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 3.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 16.3 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.5 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 1.9 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 3.3 GO:0051087 chaperone binding(GO:0051087)
0.0 0.7 GO:0051537 ferrous iron binding(GO:0008198) 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)