Motif ID: Six6

Z-value: 0.482


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_729397580.501.0e-05Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_140607334 7.598 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_+_98412461 5.586 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr6_-_23248264 5.474 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_98422961 4.296 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr18_+_56432116 4.013 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_-_142966709 3.691 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_-_114564315 3.575 ENSMUST00000111816.2
 Trim71
tripartite motif-containing 71
chr11_-_102365111 3.310 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr1_+_139454747 2.994 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr16_+_84774123 2.839 ENSMUST00000114195.1
 Jam2
junction adhesion molecule 2
chr10_+_24595623 2.754 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr7_+_46847128 2.629 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr15_-_82244716 2.607 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr11_+_78324200 2.559 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr1_+_45311538 2.453 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr1_+_74713551 2.361 ENSMUST00000027356.5
 Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr10_+_128238034 2.172 ENSMUST00000105245.2
 Timeless
timeless circadian clock 1
chr15_-_75894474 2.142 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr8_-_94918012 2.078 ENSMUST00000077955.5
 Ccdc102a
coiled-coil domain containing 102A
chr18_-_88927447 2.072 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.6 GO:0007386 compartment pattern specification(GO:0007386)
1.2 5.9 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
1.9 5.6 GO:0044849 estrous cycle(GO:0044849)
0.9 5.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 4.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 3.6 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 3.3 GO:0014823 response to activity(GO:0014823)
0.6 3.0 GO:0051661 maintenance of centrosome location(GO:0051661)
0.7 2.8 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.5 2.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.5 2.6 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.3 2.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 2.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.5 2.4 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 2.3 GO:0018345 protein palmitoylation(GO:0018345)
0.3 2.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 2.2 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 2.1 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 2.1 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.0 2.1 GO:0007162 negative regulation of cell adhesion(GO:0007162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.4 5.6 GO:0043219 lateral loop(GO:0043219)
0.1 5.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 5.1 GO:0000776 kinetochore(GO:0000776)
0.0 3.3 GO:0014704 intercalated disc(GO:0014704)
0.6 3.0 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.8 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 2.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 2.1 GO:0016459 myosin complex(GO:0016459)
0.0 2.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.6 1.8 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.7 GO:0097542 ciliary tip(GO:0097542)
0.0 1.6 GO:0044306 neuron projection terminus(GO:0044306)
0.1 1.4 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.7 5.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.2 5.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 5.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.7 5.6 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 5.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.7 4.3 GO:0019841 retinol binding(GO:0019841)
0.0 3.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 3.6 GO:0035198 miRNA binding(GO:0035198)
0.1 2.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.7 2.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.4 2.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 2.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 2.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 2.4 GO:0008017 microtubule binding(GO:0008017)
0.1 2.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 2.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.4 2.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 2.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.9 GO:0005516 calmodulin binding(GO:0005516)