Motif ID: Smad1

Z-value: 1.241


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.491.7e-05Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_73483602 10.781 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr6_-_55175019 6.801 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr7_-_103843154 6.510 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr18_+_20665250 5.562 ENSMUST00000075312.3
 Ttr
transthyretin
chr10_+_79988584 5.536 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr12_+_109452833 4.775 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr2_+_93642307 4.711 ENSMUST00000042078.3
ENSMUST00000111254.1
 Alx4

aristaless-like homeobox 4

chr17_-_32166879 4.653 ENSMUST00000087723.3
 Notch3
notch 3
chr6_+_4504814 4.648 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr11_+_32296489 4.576 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr1_-_171234290 4.166 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_-_142576492 4.116 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr9_-_114564315 3.885 ENSMUST00000111816.2
 Trim71
tripartite motif-containing 71
chr11_-_55419898 3.866 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr19_-_24031006 3.859 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr8_+_104101625 3.736 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr17_-_84682932 3.700 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr17_+_35439155 3.456 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr19_+_20601958 3.129 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr7_-_144738520 3.116 ENSMUST00000118556.2
ENSMUST00000033393.8
 Ano1

anoctamin 1, calcium activated chloride channel


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 767 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 12.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.0 12.7 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.4 10.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 9.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.6 8.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.7 7.0 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.4 6.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.3 6.9 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
1.3 6.5 GO:0015671 oxygen transport(GO:0015671)
0.1 6.4 GO:0048844 artery morphogenesis(GO:0048844)
1.3 6.3 GO:0015705 iodide transport(GO:0015705)
0.8 5.6 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.4 5.5 GO:0043589 skin morphogenesis(GO:0043589)
0.1 5.4 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
1.8 5.3 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.5 5.2 GO:0015884 folic acid transport(GO:0015884)
0.4 5.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
1.7 5.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
1.0 5.0 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
1.2 4.7 GO:0048819 regulation of hair follicle maturation(GO:0048819) regulation of catagen(GO:0051794)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 301 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 25.0 GO:0070062 extracellular exosome(GO:0070062)
0.0 20.2 GO:0005615 extracellular space(GO:0005615)
0.1 20.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 19.3 GO:0072562 blood microparticle(GO:0072562)
0.0 17.0 GO:0005667 transcription factor complex(GO:0005667)
0.2 15.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 10.0 GO:0005925 focal adhesion(GO:0005925)
0.1 8.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 8.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.7 8.6 GO:0042612 MHC class I protein complex(GO:0042612)
2.1 8.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 7.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 6.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 6.9 GO:0005581 collagen trimer(GO:0005581)
0.2 6.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.6 6.5 GO:0005833 hemoglobin complex(GO:0005833)
0.0 6.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 5.8 GO:0031012 extracellular matrix(GO:0031012)
0.1 5.7 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 486 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 18.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 18.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 10.9 GO:0071837 HMG box domain binding(GO:0071837)
2.6 10.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 10.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 10.0 GO:0008201 heparin binding(GO:0008201)
0.3 9.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.6 7.6 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 7.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.6 6.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 6.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.6 6.3 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
1.0 5.8 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.8 5.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 5.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
1.1 5.5 GO:0002060 purine nucleobase binding(GO:0002060)
0.9 5.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 5.1 GO:0005178 integrin binding(GO:0005178)
1.6 4.9 GO:0005534 galactose binding(GO:0005534)