Motif ID: Smad2

Z-value: 0.474


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.524.4e-06Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 68 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_42583628 3.450 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr9_-_119578981 3.153 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_-_116237767 3.150 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr6_-_6882068 2.859 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr19_+_59458372 2.747 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr8_-_87959560 2.687 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr4_+_11191726 2.606 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr6_+_83137089 2.263 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr3_+_127633134 2.217 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr15_+_57694651 2.148 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr16_+_64851991 1.753 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr6_-_55175019 1.572 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr5_-_113800356 1.487 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr17_-_35700520 1.469 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr13_-_78199757 1.414 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr4_+_11191354 1.360 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr15_-_103251465 1.160 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr7_-_45052865 1.115 ENSMUST00000057293.6
 Prr12
proline rich 12
chr13_+_23752267 1.088 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr7_+_82867327 1.050 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 4.0 GO:0006270 DNA replication initiation(GO:0006270)
0.7 3.4 GO:0021764 amygdala development(GO:0021764)
1.1 3.2 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.5 3.1 GO:0045218 zonula adherens maintenance(GO:0045218)
1.0 2.9 GO:0060166 olfactory pit development(GO:0060166)
0.1 2.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 2.2 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 2.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 1.6 GO:0009636 response to toxic substance(GO:0009636)
0.3 1.5 GO:1903012 positive regulation of bone development(GO:1903012)
0.3 1.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 1.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 1.2 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.4 1.1 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 1.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.0 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 1.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.9 GO:0043248 proteasome assembly(GO:0043248)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.3 3.1 GO:0005915 zonula adherens(GO:0005915)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.3 1.0 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.8 GO:0043218 compact myelin(GO:0043218)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.5 GO:0005827 polar microtubule(GO:0005827)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.5 3.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 3.1 GO:0070097 delta-catenin binding(GO:0070097)
0.1 2.9 GO:0071837 HMG box domain binding(GO:0071837)
0.2 2.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 2.2 GO:0070888 E-box binding(GO:0070888)
0.0 2.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 1.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.2 1.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.3 1.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.2 1.0 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 1.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.6 GO:0001727 lipid kinase activity(GO:0001727)