Motif ID: Smad2

Z-value: 0.474


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.524.4e-06Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_42583628 3.450 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr9_-_119578981 3.153 ENSMUST00000117911.1
ENSMUST00000120420.1
Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_-_116237767 3.150 ENSMUST00000182834.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr6_-_6882068 2.859 ENSMUST00000142635.1
ENSMUST00000052609.8
Dlx5

distal-less homeobox 5

chr19_+_59458372 2.747 ENSMUST00000062216.3
Emx2
empty spiracles homeobox 2
chr8_-_87959560 2.687 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr4_+_11191726 2.606 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr6_+_83137089 2.263 ENSMUST00000121093.1
ENSMUST00000087938.4
Rtkn

rhotekin

chr3_+_127633134 2.217 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr15_+_57694651 2.148 ENSMUST00000096430.4
Zhx2
zinc fingers and homeoboxes 2
chr16_+_64851991 1.753 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr6_-_55175019 1.572 ENSMUST00000003569.5
Inmt
indolethylamine N-methyltransferase
chr5_-_113800356 1.487 ENSMUST00000160374.1
ENSMUST00000067853.5
Tmem119

transmembrane protein 119

chr17_-_35700520 1.469 ENSMUST00000119825.1
Ddr1
discoidin domain receptor family, member 1
chr13_-_78199757 1.414 ENSMUST00000091458.6
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr4_+_11191354 1.360 ENSMUST00000170901.1
Ccne2
cyclin E2
chr15_-_103251465 1.160 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
Nfe2




nuclear factor, erythroid derived 2




chr7_-_45052865 1.115 ENSMUST00000057293.6
Prr12
proline rich 12
chr13_+_23752267 1.088 ENSMUST00000091703.2
Hist1h3b
histone cluster 1, H3b
chr7_+_82867327 1.050 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr10_-_37138863 1.037 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr17_-_25861456 0.954 ENSMUST00000079461.8
ENSMUST00000176923.1
Wdr90

WD repeat domain 90

chr3_+_89136133 0.954 ENSMUST00000047111.6
Pklr
pyruvate kinase liver and red blood cell
chr14_-_20496780 0.856 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chrX_-_94123359 0.787 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx


zinc finger protein X-linked


chrX_-_20931520 0.780 ENSMUST00000001156.7
Cfp
complement factor properdin
chr11_+_63131512 0.772 ENSMUST00000018361.3
Pmp22
peripheral myelin protein 22
chr8_-_90908415 0.734 ENSMUST00000098517.1
Gm6658
predicted gene 6658
chr4_+_117849193 0.730 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr10_-_49788743 0.725 ENSMUST00000105483.1
ENSMUST00000105487.1
Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr13_+_104817171 0.674 ENSMUST00000022230.8
Srek1ip1
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr17_-_34615965 0.668 ENSMUST00000097345.3
ENSMUST00000015611.7
Egfl8

EGF-like domain 8

chr3_+_135438722 0.616 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chrX_-_7947848 0.595 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
Hdac6


histone deacetylase 6


chr17_+_7925990 0.580 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr2_-_91950386 0.564 ENSMUST00000111303.1
Dgkz
diacylglycerol kinase zeta
chr3_+_89136572 0.549 ENSMUST00000107482.3
ENSMUST00000127058.1
Pklr

pyruvate kinase liver and red blood cell

chr10_+_80150448 0.528 ENSMUST00000153477.1
Midn
midnolin
chr1_-_172297989 0.522 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr10_+_80151154 0.508 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn

midnolin

chr11_+_101119938 0.503 ENSMUST00000043680.8
Tubg1
tubulin, gamma 1
chr14_-_12345847 0.492 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr8_-_105637403 0.481 ENSMUST00000182046.1
Gm5914
predicted gene 5914
chr9_+_44107286 0.479 ENSMUST00000152956.1
ENSMUST00000114815.1
C1qtnf5

C1q and tumor necrosis factor related protein 5

chr18_-_42579652 0.462 ENSMUST00000054738.3
Gpr151
G protein-coupled receptor 151
chr7_-_29180699 0.462 ENSMUST00000059642.10
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr7_-_29180454 0.423 ENSMUST00000182328.1
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr13_-_104816908 0.352 ENSMUST00000022228.6
Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr8_+_109705549 0.333 ENSMUST00000034163.8
Zfp821
zinc finger protein 821
chr7_+_101321703 0.299 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
Stard10




START domain containing 10




chr6_+_125009665 0.295 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
Zfp384




zinc finger protein 384




chr2_-_128967725 0.289 ENSMUST00000099385.2
Gm10762
predicted gene 10762
chrX_-_7947763 0.267 ENSMUST00000154244.1
Hdac6
histone deacetylase 6
chr11_-_75190458 0.258 ENSMUST00000044949.4
Dph1
DPH1 homolog (S. cerevisiae)
chr4_+_117849361 0.257 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_34654342 0.245 ENSMUST00000108069.1
Kctd15
potassium channel tetramerisation domain containing 15
chr2_+_177768044 0.240 ENSMUST00000108942.3
Gm14322
predicted gene 14322
chr8_-_105637350 0.219 ENSMUST00000182863.1
Gm5914
predicted gene 5914
chrX_-_7947553 0.211 ENSMUST00000133349.1
Hdac6
histone deacetylase 6
chr4_-_155010984 0.206 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
Plch2


phospholipase C, eta 2


chr14_-_18331855 0.205 ENSMUST00000022296.6
Ube2e1
ubiquitin-conjugating enzyme E2E 1
chr15_+_102102926 0.180 ENSMUST00000169627.1
ENSMUST00000046144.9
Tenc1

tensin like C1 domain-containing phosphatase

chrX_+_99821021 0.179 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr18_+_40258361 0.143 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr12_+_33147693 0.138 ENSMUST00000077456.6
ENSMUST00000110824.2
Atxn7l1

ataxin 7-like 1

chr14_+_21500879 0.135 ENSMUST00000182964.1
Kat6b
K(lysine) acetyltransferase 6B
chr1_-_179803625 0.041 ENSMUST00000027768.7
Ahctf1
AT hook containing transcription factor 1
chr14_-_31168587 0.008 ENSMUST00000036618.7
Stab1
stabilin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
1.0 2.9 GO:0060166 olfactory pit development(GO:0060166)
0.7 3.4 GO:0021764 amygdala development(GO:0021764)
0.5 3.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.4 1.1 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.3 1.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.5 GO:1903012 positive regulation of bone development(GO:1903012)
0.3 1.0 GO:0072697 protein localization to cell cortex(GO:0072697)
0.3 4.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 1.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.2 0.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 1.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 4.0 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.2 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.5 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 2.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.9 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.8 GO:0032060 bleb assembly(GO:0032060)
0.0 1.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 2.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.5 GO:0060746 parental behavior(GO:0060746)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 2.2 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.6 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.5 GO:0070206 protein trimerization(GO:0070206)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0042585 germinal vesicle(GO:0042585)
0.3 3.1 GO:0005915 zonula adherens(GO:0005915)
0.2 3.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.5 GO:0005827 polar microtubule(GO:0005827)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.8 GO:0043218 compact myelin(GO:0043218)
0.0 1.1 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.5 3.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 1.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.3 3.1 GO:0070097 delta-catenin binding(GO:0070097)
0.2 2.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 1.0 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 1.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 4.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.5 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.1 0.6 GO:0001727 lipid kinase activity(GO:0001727)
0.1 2.2 GO:0070888 E-box binding(GO:0070888)
0.1 3.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.0 1.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 2.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)