Motif ID: Smad3

Z-value: 0.943


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_63711994-0.362.2e-03Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Showing 1 to 20 of 88 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_23533869 13.775 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_22042949 13.414 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr13_-_21833575 10.919 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr13_-_22035589 10.204 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr14_-_62456286 9.782 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr13_-_21787218 8.825 ENSMUST00000091751.2
 Hist1h2an
histone cluster 1, H2an
chr15_+_81936753 8.668 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr13_+_21810428 8.045 ENSMUST00000091745.5
 Hist1h2ao
histone cluster 1, H2ao
chr13_-_23571151 7.974 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae
chr15_+_81936911 7.972 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr13_-_21832194 6.263 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr19_+_5740885 5.993 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr13_+_23581563 5.021 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_-_21750505 4.696 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr11_+_58954675 4.649 ENSMUST00000047697.5
ENSMUST00000108817.3
 Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr1_-_134235420 4.261 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr13_+_23531044 4.202 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr6_-_36811361 4.104 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr13_+_22043189 4.096 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr11_-_116110211 4.024 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 71.6 GO:0006342 chromatin silencing(GO:0006342)
1.4 26.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 12.5 GO:0006397 mRNA processing(GO:0006397)
0.3 9.8 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.6 7.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 6.8 GO:0006334 nucleosome assembly(GO:0006334)
2.0 6.0 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.5 4.4 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
1.4 4.3 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
1.4 4.1 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.8 4.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
1.3 3.9 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
1.2 3.5 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 3.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.4 3.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.6 2.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039) peptidyl-aspartic acid modification(GO:0018197)
0.1 2.3 GO:0003341 cilium movement(GO:0003341)
0.7 2.2 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.6 1.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 1.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 72.5 GO:0000786 nucleosome(GO:0000786)
0.1 32.3 GO:0000790 nuclear chromatin(GO:0000790)
0.1 15.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.1 9.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 4.3 GO:0032279 asymmetric synapse(GO:0032279)
0.1 4.0 GO:0031901 early endosome membrane(GO:0031901)
0.3 3.5 GO:0097449 astrocyte projection(GO:0097449)
0.0 3.5 GO:0030133 transport vesicle(GO:0030133)
0.2 3.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.4 GO:0005771 multivesicular body(GO:0005771)
0.7 2.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.4 GO:0014704 intercalated disc(GO:0014704)
0.1 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.9 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 0.9 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 52.3 GO:0003677 DNA binding(GO:0003677)
0.1 36.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 24.7 GO:0042393 histone binding(GO:0042393)
1.1 9.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 6.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.7 4.4 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.1 4.4 GO:0050699 WW domain binding(GO:0050699)
0.6 4.3 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
1.4 4.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 3.9 GO:0005518 collagen binding(GO:0005518)
1.2 3.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 3.2 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.1 2.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 2.4 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 2.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.9 GO:0030552 cAMP binding(GO:0030552)
0.0 1.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 1.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 1.7 GO:0004708 MAP kinase kinase activity(GO:0004708)