Motif ID: Smad3

Z-value: 0.943


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_63711994-0.362.2e-03Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_23533869 13.775 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_22042949 13.414 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr13_-_21833575 10.919 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr13_-_22035589 10.204 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr14_-_62456286 9.782 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr13_-_21787218 8.825 ENSMUST00000091751.2
 Hist1h2an
histone cluster 1, H2an
chr15_+_81936753 8.668 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr13_+_21810428 8.045 ENSMUST00000091745.5
 Hist1h2ao
histone cluster 1, H2ao
chr13_-_23571151 7.974 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae
chr15_+_81936911 7.972 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr13_-_21832194 6.263 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr19_+_5740885 5.993 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr13_+_23581563 5.021 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_-_21750505 4.696 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr11_+_58954675 4.649 ENSMUST00000047697.5
ENSMUST00000108817.3
 Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr1_-_134235420 4.261 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr13_+_23531044 4.202 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr6_-_36811361 4.104 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr13_+_22043189 4.096 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr11_-_116110211 4.024 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr2_-_173276144 4.023 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr15_-_81697256 3.857 ENSMUST00000072910.5
 Chadl
chondroadherin-like
chr13_-_23551648 3.648 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr1_+_172341197 3.550 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr1_+_146497614 3.310 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr19_-_23448322 3.193 ENSMUST00000036069.6
 Mamdc2
MAM domain containing 2
chr12_+_100779074 2.954 ENSMUST00000110073.1
ENSMUST00000110070.1
 9030617O03Rik

RIKEN cDNA 9030617O03 gene

chr13_+_21735055 2.801 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr13_+_23571382 2.737 ENSMUST00000079251.5
 Hist1h2bg
histone cluster 1, H2bg
chr6_+_136808248 2.721 ENSMUST00000074556.4
 H2afj
H2A histone family, member J
chr13_+_21833736 2.648 ENSMUST00000180288.1
ENSMUST00000110467.1
 Hist1h2br

histone cluster 1 H2br

chr14_+_32028989 2.616 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr13_+_23684192 2.551 ENSMUST00000018246.4
 Hist1h2bc
histone cluster 1, H2bc
chr2_+_178193075 2.468 ENSMUST00000103065.1
 Phactr3
phosphatase and actin regulator 3
chr1_-_126492683 2.427 ENSMUST00000162877.1
 Nckap5
NCK-associated protein 5
chr4_+_140986873 2.395 ENSMUST00000168047.1
ENSMUST00000037055.7
ENSMUST00000127833.2
 Atp13a2


ATPase type 13A2


chr13_+_22035821 2.390 ENSMUST00000110455.2
 Hist1h2bk
histone cluster 1, H2bk
chr17_-_27623263 2.321 ENSMUST00000062397.6
ENSMUST00000176876.1
 Nudt3

nudix (nucleotide diphosphate linked moiety X)-type motif 3

chr10_+_33905015 2.313 ENSMUST00000169670.1
 Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chr17_-_27623441 2.118 ENSMUST00000025050.5
 Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr13_+_21787461 2.086 ENSMUST00000110473.2
ENSMUST00000102982.1
 Hist1h2bp

histone cluster 1, H2bp

chr13_-_23683941 2.022 ENSMUST00000171127.1
 Hist1h2ac
histone cluster 1, H2ac
chr14_+_64589802 2.004 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr1_-_126492900 1.975 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr13_-_21810190 1.960 ENSMUST00000110469.1
ENSMUST00000091749.2
 Hist1h2bq

histone cluster 1, H2bq

chr11_-_102447647 1.919 ENSMUST00000049057.4
 Fam171a2
family with sequence similarity 171, member A2
chrX_-_95026671 1.880 ENSMUST00000096367.3
 Spin4
spindlin family, member 4
chrX_+_10485121 1.853 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr5_-_53707532 1.840 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr16_-_45158183 1.739 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr9_-_66514567 1.718 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr4_+_102570065 1.695 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_130055010 1.440 ENSMUST00000123617.1
 Col16a1
collagen, type XVI, alpha 1
chr15_-_58823530 1.437 ENSMUST00000072113.5
 Tmem65
transmembrane protein 65
chrX_-_20291776 1.379 ENSMUST00000072451.4
 Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr10_-_120979327 1.248 ENSMUST00000119944.1
ENSMUST00000119093.1
 Lemd3

LEM domain containing 3

chr16_-_15594507 1.183 ENSMUST00000115776.1
ENSMUST00000115777.3
 Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr9_+_13621646 1.095 ENSMUST00000034401.8
 Maml2
mastermind like 2 (Drosophila)
chrX_+_143664290 1.092 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr16_-_15594472 1.056 ENSMUST00000118236.1
ENSMUST00000096234.3
 Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr9_-_106656081 0.977 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr12_+_119945957 0.948 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chr7_+_44384803 0.896 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr6_+_129533183 0.892 ENSMUST00000032264.6
 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr2_-_104257400 0.864 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr11_-_87828289 0.861 ENSMUST00000136446.1
 Lpo
lactoperoxidase
chr1_+_75210832 0.857 ENSMUST00000027401.4
ENSMUST00000144355.1
ENSMUST00000123825.1
 Stk16


serine/threonine kinase 16


chr12_+_12911986 0.818 ENSMUST00000085720.1
 Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr7_+_51880312 0.674 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr13_+_23746734 0.666 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr14_+_119138415 0.661 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chrX_+_143664365 0.640 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr2_-_30194112 0.518 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr18_-_74207771 0.509 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr7_+_82867327 0.506 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr7_-_81454751 0.495 ENSMUST00000098331.3
ENSMUST00000178892.1
 Cpeb1

cytoplasmic polyadenylation element binding protein 1

chr17_-_6827990 0.490 ENSMUST00000181895.1
 Gm2885
predicted gene 2885
chr11_+_46436925 0.453 ENSMUST00000152119.1
ENSMUST00000140027.1
ENSMUST00000020665.6
ENSMUST00000170928.1
ENSMUST00000109231.1
ENSMUST00000109232.3
ENSMUST00000128940.1
 Med7






mediator complex subunit 7






chr9_+_109038565 0.413 ENSMUST00000112059.3
ENSMUST00000026737.5
 Shisa5

shisa homolog 5 (Xenopus laevis)

chr1_-_75210732 0.286 ENSMUST00000113623.1
 Glb1l
galactosidase, beta 1-like
chrX_-_144688180 0.282 ENSMUST00000040184.3
 Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr6_-_129533267 0.276 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr2_-_29869785 0.243 ENSMUST00000047607.1
 2600006K01Rik
RIKEN cDNA 2600006K01 gene
chr9_+_21196705 0.239 ENSMUST00000003395.9
 Pde4a
phosphodiesterase 4A, cAMP specific
chr9_+_69454066 0.214 ENSMUST00000134907.1
 Anxa2
annexin A2
chr3_+_102734496 0.158 ENSMUST00000029451.5
 Tspan2
tetraspanin 2
chr11_-_79254663 0.074 ENSMUST00000017821.5
 Wsb1
WD repeat and SOCS box-containing 1
chrX_-_150814265 0.025 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.5 4.4 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
1.4 4.3 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
1.4 26.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.4 4.1 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
1.3 3.9 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
1.2 3.5 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.8 4.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.7 2.2 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.7 71.6 GO:0006342 chromatin silencing(GO:0006342)
0.6 7.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.6 1.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.6 2.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039) peptidyl-aspartic acid modification(GO:0018197)
0.4 3.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 9.8 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.3 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 1.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.9 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 6.8 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.7 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 3.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 1.4 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 1.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 1.4 GO:0051894 integrin activation(GO:0033622) positive regulation of focal adhesion assembly(GO:0051894)
0.1 2.3 GO:0003341 cilium movement(GO:0003341)
0.1 0.2 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.5 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0 1.0 GO:0014047 glutamate secretion(GO:0014047)
0.0 12.5 GO:0006397 mRNA processing(GO:0006397)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.7 GO:0008643 carbohydrate transport(GO:0008643)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.9 72.5 GO:0000786 nucleosome(GO:0000786)
0.7 2.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.3 3.5 GO:0097449 astrocyte projection(GO:0097449)
0.2 4.3 GO:0032279 asymmetric synapse(GO:0032279)
0.2 3.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.4 GO:0005771 multivesicular body(GO:0005771)
0.1 4.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 32.3 GO:0000790 nuclear chromatin(GO:0000790)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 15.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 1.4 GO:0014704 intercalated disc(GO:0014704)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 3.5 GO:0030133 transport vesicle(GO:0030133)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.2 3.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.1 9.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.7 4.4 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.6 4.3 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.3 2.4 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.2 6.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 1.0 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 0.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 2.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 4.4 GO:0050699 WW domain binding(GO:0050699)
0.1 0.9 GO:0030957 Tat protein binding(GO:0030957)
0.1 24.7 GO:0042393 histone binding(GO:0042393)
0.1 0.7 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 3.9 GO:0005518 collagen binding(GO:0005518)
0.1 1.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 36.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.0 2.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.9 GO:0030552 cAMP binding(GO:0030552)
0.0 0.5 GO:0035925 translation repressor activity, nucleic acid binding(GO:0000900) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 52.3 GO:0003677 DNA binding(GO:0003677)
0.0 3.2 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 0.9 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.4 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)