Motif ID: Smad4

Z-value: 1.387


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.132.9e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 176 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103314944 19.489 ENSMUST00000179363.1
Fam181a
family with sequence similarity 181, member A
chr10_-_42583628 18.572 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_+_70562854 14.229 ENSMUST00000130998.1
Gad1
glutamate decarboxylase 1
chr2_+_70563435 13.675 ENSMUST00000123330.1
Gad1
glutamate decarboxylase 1
chr18_+_57133065 13.447 ENSMUST00000075770.6
Megf10
multiple EGF-like-domains 10
chr4_-_117178726 12.985 ENSMUST00000153953.1
ENSMUST00000106436.1
Kif2c

kinesin family member 2C

chr14_+_50944499 12.629 ENSMUST00000178092.1
Pnp
purine-nucleoside phosphorylase
chr7_+_45216671 12.531 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr14_-_54577578 12.434 ENSMUST00000054487.8
Ajuba
ajuba LIM protein
chr7_+_45215753 9.744 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
Tead2


TEA domain family member 2


chr3_+_89436699 9.680 ENSMUST00000038942.3
ENSMUST00000130858.1
Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr19_-_40271506 9.380 ENSMUST00000068439.6
Pdlim1
PDZ and LIM domain 1 (elfin)
chr11_-_89302545 8.371 ENSMUST00000061728.3
Nog
noggin
chr17_+_75178797 8.353 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr7_-_89517576 8.263 ENSMUST00000041761.5
Prss23
protease, serine, 23
chr3_+_89436736 8.172 ENSMUST00000146630.1
ENSMUST00000145753.1
Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr17_-_70851710 7.942 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr7_+_110221697 7.662 ENSMUST00000033325.7
Swap70
SWA-70 protein
chr6_+_15720654 7.652 ENSMUST00000101663.3
Mdfic
MyoD family inhibitor domain containing
chr5_+_92683625 7.648 ENSMUST00000168878.1
Shroom3
shroom family member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 27.9 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.1 22.2 GO:0030903 notochord development(GO:0030903)
1.1 21.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
3.7 18.6 GO:0021764 amygdala development(GO:0021764)
0.7 15.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
3.1 15.6 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
2.6 13.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
4.2 12.6 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
2.5 12.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
4.0 11.9 GO:0015889 cobalamin transport(GO:0015889)
0.3 10.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
1.7 8.6 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
2.1 8.4 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.5 7.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 7.7 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.3 7.7 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 7.7 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
2.5 7.6 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 7.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.8 7.4 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 41.4 GO:0005667 transcription factor complex(GO:0005667)
0.9 27.9 GO:0060077 inhibitory synapse(GO:0060077)
0.3 26.5 GO:0000786 nucleosome(GO:0000786)
0.0 21.7 GO:0005874 microtubule(GO:0005874)
5.3 15.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.6 13.0 GO:0001891 phagocytic cup(GO:0001891)
0.2 12.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 11.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.3 10.7 GO:0035371 microtubule plus-end(GO:0035371)
0.2 10.4 GO:0005581 collagen trimer(GO:0005581)
0.0 9.5 GO:0005730 nucleolus(GO:0005730)
0.0 8.4 GO:0005802 trans-Golgi network(GO:0005802)
0.7 7.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.5 7.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 6.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 5.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 4.3 GO:0005938 cell cortex(GO:0005938)
0.5 3.8 GO:0070652 HAUS complex(GO:0070652)
0.2 3.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.3 3.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 27.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 25.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 21.8 GO:0042393 histone binding(GO:0042393)
0.3 18.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
4.1 16.3 GO:0050436 microfibril binding(GO:0050436)
4.2 12.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
1.0 12.4 GO:0045294 alpha-catenin binding(GO:0045294)
1.7 11.9 GO:0031419 cobalamin binding(GO:0031419)
0.4 11.0 GO:0008432 JUN kinase binding(GO:0008432)
0.0 11.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.7 10.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.6 10.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 9.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 8.5 GO:0070888 E-box binding(GO:0070888)
0.1 8.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.7 7.7 GO:0030957 Tat protein binding(GO:0030957)
0.5 7.7 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 7.7 GO:0005096 GTPase activator activity(GO:0005096)
0.4 7.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 7.6 GO:0051015 actin filament binding(GO:0051015)