Motif ID: Snai1_Zeb1_Snai2

Z-value: 2.437

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.807.2e-17Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.291.4e-02Click!
Snai1mm10_v2_chr2_+_167538192_167538210-0.009.8e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_57907587 30.080 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr4_+_85205417 29.831 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr18_-_61911783 29.157 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr12_+_82616885 26.798 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr11_-_67922136 25.407 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr7_-_29281977 24.159 ENSMUST00000098604.4
ENSMUST00000108236.3
 Spint2

serine protease inhibitor, Kunitz type 2

chr15_-_66831625 23.717 ENSMUST00000164163.1
 Sla
src-like adaptor
chr3_+_75557530 21.788 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr5_-_147076482 21.639 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr19_-_57314896 19.493 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr11_-_100397740 19.107 ENSMUST00000001592.8
ENSMUST00000107403.1
 Jup

junction plakoglobin

chr7_-_27446599 18.593 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr4_+_85205120 18.272 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr2_-_32312162 18.168 ENSMUST00000155269.1
 Dnm1
dynamin 1
chrX_-_158043266 17.975 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr7_-_126704179 17.930 ENSMUST00000106364.1
 Coro1a
coronin, actin binding protein 1A
chr7_+_44384803 17.829 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr2_+_49787675 17.687 ENSMUST00000028103.6
 Lypd6b
LY6/PLAUR domain containing 6B
chr5_+_37028329 17.317 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr8_-_125898291 16.887 ENSMUST00000047239.6
 Pcnxl2
pecanex-like 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 885 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 69.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
2.5 55.0 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
6.9 48.6 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.6 45.9 GO:0030032 lamellipodium assembly(GO:0030032)
1.0 37.5 GO:0008333 endosome to lysosome transport(GO:0008333)
3.9 35.4 GO:0071420 cellular response to histamine(GO:0071420)
2.2 35.0 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.1 32.0 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
1.4 31.6 GO:0048268 clathrin coat assembly(GO:0048268)
2.6 28.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
2.3 27.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.2 27.2 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
6.7 26.8 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
8.0 24.0 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.7 23.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
4.5 22.7 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
3.7 22.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.6 21.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.6 21.3 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
1.1 20.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 332 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 155.5 GO:0043195 terminal bouton(GO:0043195)
0.7 149.2 GO:0045211 postsynaptic membrane(GO:0045211)
2.5 74.2 GO:0033268 node of Ranvier(GO:0033268)
2.0 50.7 GO:0001891 phagocytic cup(GO:0001891)
0.8 49.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.5 47.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.4 44.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
2.2 43.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
2.3 42.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.6 40.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 39.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
2.3 29.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 28.8 GO:0055037 recycling endosome(GO:0055037)
0.3 28.2 GO:0030427 site of polarized growth(GO:0030427)
1.9 26.2 GO:0043196 varicosity(GO:0043196)
3.7 26.1 GO:0070695 FHF complex(GO:0070695)
4.3 26.0 GO:0008091 spectrin(GO:0008091)
2.4 24.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.3 23.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 23.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 508 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 46.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 44.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.6 42.6 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
1.4 42.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 41.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
5.3 37.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
3.6 35.8 GO:0032036 myosin heavy chain binding(GO:0032036)
1.4 34.5 GO:0017075 syntaxin-1 binding(GO:0017075)
2.0 33.6 GO:0004890 GABA-A receptor activity(GO:0004890)
3.0 33.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.3 33.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.1 30.4 GO:0015301 anion:anion antiporter activity(GO:0015301)
2.0 29.6 GO:0050811 GABA receptor binding(GO:0050811)
1.3 28.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.5 27.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
2.1 27.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.7 27.1 GO:0005158 insulin receptor binding(GO:0005158)
2.2 27.0 GO:0004016 adenylate cyclase activity(GO:0004016)
0.9 26.1 GO:0030215 semaphorin receptor binding(GO:0030215)
1.9 25.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)