Motif ID: Sox11

Z-value: 0.397


Transcription factors associated with Sox11:

Gene SymbolEntrez IDGene Name
Sox11 ENSMUSG00000063632.5 Sox11

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox11mm10_v2_chr12_-_27342696_273427260.762.5e-14Click!


Activity profile for motif Sox11.

activity profile for motif Sox11


Sorted Z-values histogram for motif Sox11

Sorted Z-values for motif Sox11



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox11

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_16378231 2.898 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr5_+_14514918 2.226 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr2_-_79456750 2.218 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr5_-_131616599 1.745 ENSMUST00000161804.1
 Auts2
autism susceptibility candidate 2
chr9_+_89909775 1.408 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr13_-_99516537 1.380 ENSMUST00000064762.4
 Map1b
microtubule-associated protein 1B
chr11_+_69364010 1.195 ENSMUST00000166700.1
 Gm17305
predicted gene, 17305
chrX_+_85574018 1.164 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
 Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr11_+_24080664 1.118 ENSMUST00000118955.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr16_-_50330987 1.030 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr8_-_34965631 0.994 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr9_+_107888129 0.983 ENSMUST00000035202.2
 Mon1a
MON1 homolog A (yeast)
chrX_+_166344692 0.869 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr6_-_60829826 0.868 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr1_+_82233112 0.794 ENSMUST00000023262.5
 Gm9747
predicted gene 9747
chr17_-_29007925 0.735 ENSMUST00000009138.5
ENSMUST00000119274.1
 Stk38

serine/threonine kinase 38

chr4_-_44072578 0.713 ENSMUST00000173383.1
 Gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr16_+_8830093 0.704 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr14_-_52213379 0.655 ENSMUST00000140603.1
 Chd8
chromodomain helicase DNA binding protein 8
chr11_+_4873951 0.626 ENSMUST00000038570.2
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr2_+_154548888 0.625 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr17_+_43016536 0.609 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr13_-_84064772 0.608 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr2_-_36136773 0.604 ENSMUST00000028251.3
 Rbm18
RNA binding motif protein 18
chr7_-_73541738 0.591 ENSMUST00000169922.2
 Chd2
chromodomain helicase DNA binding protein 2
chr6_-_42693087 0.591 ENSMUST00000121083.1
 Fam115a
family with sequence similarity 115, member A
chr19_-_46969474 0.578 ENSMUST00000086961.7
 Nt5c2
5'-nucleotidase, cytosolic II
chr10_+_119992916 0.570 ENSMUST00000105261.2
 Grip1
glutamate receptor interacting protein 1
chrX_-_37104523 0.564 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr6_-_42693030 0.527 ENSMUST00000045140.4
 Fam115a
family with sequence similarity 115, member A
chr4_-_97584612 0.495 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_15055274 0.487 ENSMUST00000069870.3
 Arl5b
ADP-ribosylation factor-like 5B
chr11_-_69369377 0.484 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr10_+_24869982 0.484 ENSMUST00000092646.6
 Med23
mediator complex subunit 23
chr4_+_59003121 0.469 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr7_+_70388305 0.440 ENSMUST00000080024.5
 B130024G19Rik
RIKEN cDNA B130024G19 gene
chr1_+_44119952 0.431 ENSMUST00000114709.2
 Bivm
basic, immunoglobulin-like variable motif containing
chr6_-_12109583 0.420 ENSMUST00000080891.5
 Gm6578
predicted gene 6578
chr5_+_64812336 0.415 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr4_-_97584605 0.398 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_+_21848039 0.375 ENSMUST00000098238.2
ENSMUST00000108229.1
 Sfrs18

serine/arginine-rich splicing factor 18

chr2_-_36136602 0.370 ENSMUST00000122456.1
 Rbm18
RNA binding motif protein 18
chr15_-_81104999 0.363 ENSMUST00000109579.2
 Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr6_-_136173492 0.360 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr8_-_83442648 0.355 ENSMUST00000167525.1
 Scoc
short coiled-coil protein
chr9_+_32116040 0.345 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr16_-_38341812 0.335 ENSMUST00000114740.2
ENSMUST00000023501.8
 Maats1

MYCBP-associated, testis expressed 1

chr12_-_54862783 0.326 ENSMUST00000078124.7
 Cfl2
cofilin 2, muscle
chr9_+_101074727 0.307 ENSMUST00000085177.3
 Msl2
male-specific lethal 2 homolog (Drosophila)
chr5_+_144100387 0.293 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr13_+_40859768 0.293 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr7_-_55962466 0.281 ENSMUST00000032635.7
ENSMUST00000152649.1
 Nipa2

non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)

chr10_-_76110956 0.277 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr5_-_148552783 0.273 ENSMUST00000079324.7
ENSMUST00000164904.1
 Ubl3

ubiquitin-like 3

chr4_-_129378116 0.270 ENSMUST00000030610.2
 Zbtb8a
zinc finger and BTB domain containing 8a
chr12_+_8921598 0.257 ENSMUST00000020909.3
 Laptm4a
lysosomal-associated protein transmembrane 4A
chr9_+_52047150 0.228 ENSMUST00000163153.1
 Rdx
radixin
chr7_+_83631959 0.220 ENSMUST00000075418.7
ENSMUST00000117410.1
 Stard5

StAR-related lipid transfer (START) domain containing 5

chr5_+_121795034 0.220 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr11_-_64436653 0.216 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr15_+_76797628 0.216 ENSMUST00000165535.2
 Gm17271
predicted gene, 17271
chr19_+_8837676 0.207 ENSMUST00000159634.1
 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr8_+_85432686 0.125 ENSMUST00000180883.1
 1700051O22Rik
RIKEN cDNA 1700051O22 Gene
chr2_-_86347764 0.099 ENSMUST00000099894.2
 Olfr1055
olfactory receptor 1055
chr10_-_14718191 0.095 ENSMUST00000020016.4
 Gje1
gap junction protein, epsilon 1
chr5_+_145084100 0.095 ENSMUST00000124379.1
 Arpc1a
actin related protein 2/3 complex, subunit 1A
chr2_-_127247768 0.067 ENSMUST00000003759.4
 Ciao1
cytosolic iron-sulfur protein assembly 1
chr2_-_156111954 0.055 ENSMUST00000142960.2
ENSMUST00000136296.2
ENSMUST00000059647.5
ENSMUST00000109604.2
ENSMUST00000138068.1
ENSMUST00000128499.1
 Cpne1

Rbm12



copine I

RNA binding motif protein 12



chr16_-_17911303 0.046 ENSMUST00000003621.8
 Dgcr14
DiGeorge syndrome critical region gene 14
chr2_-_127247620 0.035 ENSMUST00000174030.1
ENSMUST00000174863.1
 Ciao1

cytosolic iron-sulfur protein assembly 1

chrM_+_7759 0.034 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr5_-_123141067 0.020 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.6 2.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.4 2.2 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.3 1.0 GO:1904742 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.2 1.7 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 0.6 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.2 0.5 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.1 2.9 GO:0010842 retina layer formation(GO:0010842)
0.1 1.4 GO:0061162 establishment of monopolar cell polarity(GO:0061162)
0.1 1.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 1.4 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.6 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.3 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.6 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0 0.7 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.3 GO:0033572 transferrin transport(GO:0033572)
0.0 1.0 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.3 GO:0030836 positive regulation of actin filament depolymerization(GO:0030836)
0.0 0.4 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.2 GO:0034389 lipid particle organization(GO:0034389)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0044316 cone cell pedicle(GO:0044316)
0.2 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.4 GO:0043196 varicosity(GO:0043196)
0.1 0.7 GO:0070688 MLL5-L complex(GO:0070688)
0.1 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0051286 cell tip(GO:0051286)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 0.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 2.2 GO:0005522 profilin binding(GO:0005522)
0.1 0.9 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.7 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 2.2 GO:0070888 E-box binding(GO:0070888)
0.0 1.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.0 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 1.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)