Motif ID: Sox18_Sox12
Z-value: 0.502
Transcription factors associated with Sox18_Sox12:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Sox12 | ENSMUSG00000051817.8 | Sox12 |
Sox18 | ENSMUSG00000046470.5 | Sox18 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Sox18 | mm10_v2_chr2_-_181671622_181671645 | -0.05 | 6.7e-01 | Click! |
Sox12 | mm10_v2_chr2_-_152398046_152398076 | -0.04 | 7.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.2 | GO:0048840 | otolith development(GO:0048840) |
0.3 | 2.0 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.3 | 0.8 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
0.2 | 1.2 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
0.2 | 0.7 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
0.2 | 0.9 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
0.2 | 0.9 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.2 | 0.9 | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362) |
0.2 | 0.5 | GO:0050929 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
0.2 | 1.6 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.2 | 0.5 | GO:2000409 | positive regulation of T cell extravasation(GO:2000409) |
0.1 | 0.7 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
0.1 | 0.8 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.1 | 0.5 | GO:0033326 | cerebrospinal fluid secretion(GO:0033326) |
0.1 | 0.7 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
0.1 | 0.5 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
0.1 | 0.4 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
0.1 | 0.9 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
0.1 | 0.9 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
0.1 | 0.8 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 0.2 | GO:0042940 | D-amino acid transport(GO:0042940) |
0.1 | 0.2 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
0.1 | 0.2 | GO:0045410 | positive regulation of interleukin-6 biosynthetic process(GO:0045410) |
0.1 | 0.4 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
0.1 | 0.4 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
0.1 | 0.3 | GO:0021764 | amygdala development(GO:0021764) |
0.1 | 1.4 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
0.1 | 0.2 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
0.1 | 0.4 | GO:1902965 | regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
0.1 | 0.2 | GO:0010835 | regulation of protein ADP-ribosylation(GO:0010835) |
0.1 | 0.2 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
0.1 | 0.2 | GO:0060743 | estrous cycle(GO:0044849) epithelial cell maturation involved in prostate gland development(GO:0060743) |
0.1 | 0.4 | GO:0060903 | positive regulation of meiosis I(GO:0060903) |
0.0 | 0.3 | GO:0051096 | telomere assembly(GO:0032202) positive regulation of helicase activity(GO:0051096) |
0.0 | 1.2 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.0 | 0.2 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.0 | 0.1 | GO:0097309 | cap1 mRNA methylation(GO:0097309) |
0.0 | 0.7 | GO:0015693 | magnesium ion transport(GO:0015693) |
0.0 | 0.2 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
0.0 | 0.2 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
0.0 | 0.3 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
0.0 | 0.2 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
0.0 | 0.1 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.0 | 0.2 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
0.0 | 0.2 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
0.0 | 0.1 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
0.0 | 0.2 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
0.0 | 0.3 | GO:0030035 | microspike assembly(GO:0030035) |
0.0 | 0.4 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
0.0 | 0.1 | GO:0006624 | vacuolar protein processing(GO:0006624) |
0.0 | 0.2 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
0.0 | 0.1 | GO:0006543 | glutamine catabolic process(GO:0006543) |
0.0 | 0.2 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
0.0 | 0.2 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
0.0 | 0.2 | GO:0016576 | histone dephosphorylation(GO:0016576) |
0.0 | 0.2 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
0.0 | 1.0 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
0.0 | 0.1 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
0.0 | 0.2 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) |
0.0 | 0.2 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) |
0.0 | 0.0 | GO:0050883 | musculoskeletal movement, spinal reflex action(GO:0050883) |
0.0 | 0.2 | GO:0097264 | self proteolysis(GO:0097264) |
0.0 | 1.2 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 0.1 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267) |
0.0 | 0.1 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
0.0 | 0.2 | GO:0033572 | transferrin transport(GO:0033572) |
0.0 | 0.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.0 | 0.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.0 | 0.1 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.0 | 0.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 0.1 | GO:0071476 | cellular hypotonic response(GO:0071476) |
0.0 | 1.1 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
0.0 | 0.4 | GO:0006308 | DNA catabolic process(GO:0006308) |
0.0 | 0.1 | GO:0036518 | chemorepulsion of dopaminergic neuron axon(GO:0036518) |
0.0 | 0.3 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
0.0 | 0.2 | GO:0033129 | positive regulation of histone phosphorylation(GO:0033129) |
0.0 | 0.4 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
0.0 | 0.2 | GO:0050765 | negative regulation of phagocytosis(GO:0050765) |
0.0 | 0.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
0.0 | 0.1 | GO:0036265 | RNA (guanine-N7)-methylation(GO:0036265) |
0.0 | 0.1 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.0 | 0.5 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
0.0 | 0.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
0.0 | 0.2 | GO:0032620 | interleukin-17 production(GO:0032620) |
0.0 | 0.7 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | GO:0005595 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
0.3 | 1.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
0.2 | 0.9 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
0.1 | 0.7 | GO:0044316 | cone cell pedicle(GO:0044316) |
0.1 | 1.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.1 | 1.2 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.1 | 0.3 | GO:0031673 | H zone(GO:0031673) |
0.1 | 2.0 | GO:0030673 | axolemma(GO:0030673) |
0.1 | 2.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 0.8 | GO:0001527 | microfibril(GO:0001527) |
0.1 | 0.5 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.0 | 0.6 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 0.9 | GO:0016580 | Sin3 complex(GO:0016580) |
0.0 | 0.3 | GO:0070187 | telosome(GO:0070187) |
0.0 | 0.5 | GO:0035631 | CD40 receptor complex(GO:0035631) |
0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
0.0 | 0.1 | GO:0005745 | m-AAA complex(GO:0005745) |
0.0 | 0.3 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 1.0 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.4 | GO:0051233 | spindle midzone(GO:0051233) |
0.0 | 0.6 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.1 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
0.0 | 0.1 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
0.0 | 0.3 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.4 | 1.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.2 | 0.7 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.2 | 1.6 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.2 | 2.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.2 | 0.5 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) |
0.1 | 0.9 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
0.1 | 0.9 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
0.1 | 1.4 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
0.1 | 0.9 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
0.1 | 0.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.1 | 0.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.1 | 0.3 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
0.1 | 0.3 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
0.1 | 0.5 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.1 | 0.2 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
0.1 | 0.2 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
0.1 | 0.3 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
0.1 | 0.2 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.0 | 0.8 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.0 | 1.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 0.2 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
0.0 | 0.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.0 | 0.7 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.0 | 0.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.0 | 0.2 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
0.0 | 0.5 | GO:0001848 | complement binding(GO:0001848) |
0.0 | 0.4 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
0.0 | 1.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.3 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
0.0 | 0.1 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
0.0 | 0.2 | GO:0033192 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.0 | 0.1 | GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity(GO:0008176) |
0.0 | 0.1 | GO:0004359 | glutaminase activity(GO:0004359) |
0.0 | 0.2 | GO:0032051 | clathrin light chain binding(GO:0032051) |
0.0 | 0.1 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
0.0 | 0.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.0 | 0.5 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.0 | 0.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 0.2 | GO:0031996 | thioesterase binding(GO:0031996) |
0.0 | 1.0 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.0 | 0.0 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 0.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
0.0 | 1.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 0.1 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.0 | 0.0 | GO:0001588 | dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
0.0 | 0.1 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.2 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
0.0 | 0.1 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.0 | 0.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.1 | GO:0032407 | MutSalpha complex binding(GO:0032407) |
0.0 | 0.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |