Motif ID: Sox2

Z-value: 3.750


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_34650005-0.515.4e-06Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_143933089 43.980 ENSMUST00000087313.3
 Dcx
doublecortin
chrX_-_143933204 41.164 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr17_-_79355082 35.679 ENSMUST00000068958.7
 Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr10_+_29143996 34.510 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr11_-_98329641 34.016 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr10_+_80300997 33.561 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr1_+_136131382 32.185 ENSMUST00000075164.4
 Kif21b
kinesin family member 21B
chr10_-_29144194 29.816 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr7_+_99466004 26.173 ENSMUST00000037359.2
 Klhl35
kelch-like 35
chr8_+_45507768 24.716 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr10_-_84440591 23.485 ENSMUST00000020220.8
 Nuak1
NUAK family, SNF1-like kinase, 1
chr1_-_12991109 23.311 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr4_-_20778527 22.986 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr8_-_69184177 22.937 ENSMUST00000185176.1
 Lzts1
leucine zipper, putative tumor suppressor 1
chr8_-_33747724 21.724 ENSMUST00000179364.1
 Smim18
small integral membrane protein 18
chr5_-_22344690 21.202 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr1_-_138842429 20.719 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr2_-_65567465 20.164 ENSMUST00000066432.5
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr2_-_65567505 20.048 ENSMUST00000100069.2
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr8_+_34807287 19.994 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 441 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.9 135.9 GO:0021819 layer formation in cerebral cortex(GO:0021819)
5.5 60.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
3.7 58.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.6 53.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.7 50.9 GO:0000045 autophagosome assembly(GO:0000045)
1.3 49.5 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
5.4 48.9 GO:0035881 amacrine cell differentiation(GO:0035881)
1.2 47.5 GO:0006376 mRNA splice site selection(GO:0006376)
2.9 46.0 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.4 45.9 GO:0048813 dendrite morphogenesis(GO:0048813)
8.0 40.2 GO:0046684 response to pyrethroid(GO:0046684)
8.0 39.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.2 39.6 GO:0007018 microtubule-based movement(GO:0007018)
12.7 38.0 GO:2000297 negative regulation of synapse maturation(GO:2000297)
3.2 35.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 35.4 GO:0006644 phospholipid metabolic process(GO:0006644)
0.5 35.0 GO:0002028 regulation of sodium ion transport(GO:0002028)
1.0 31.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 29.7 GO:0021954 central nervous system neuron development(GO:0021954)
0.5 28.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 124.5 GO:0005874 microtubule(GO:0005874)
2.6 65.6 GO:0071565 nBAF complex(GO:0071565)
3.0 60.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
2.4 54.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.6 52.6 GO:0043198 dendritic shaft(GO:0043198)
5.0 50.1 GO:0045298 tubulin complex(GO:0045298)
5.2 47.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.7 44.8 GO:0034704 calcium channel complex(GO:0034704)
2.5 40.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
4.4 39.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 39.6 GO:0060076 excitatory synapse(GO:0060076)
0.6 37.8 GO:0005871 kinesin complex(GO:0005871)
0.2 37.1 GO:0005802 trans-Golgi network(GO:0005802)
0.5 35.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.6 35.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.7 34.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
3.4 33.5 GO:0044327 dendritic spine head(GO:0044327)
2.5 32.6 GO:0016342 catenin complex(GO:0016342)
4.5 31.8 GO:0031933 telomeric heterochromatin(GO:0031933)
0.3 26.1 GO:0044306 neuron projection terminus(GO:0044306)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 279 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 146.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 103.6 GO:0044822 poly(A) RNA binding(GO:0044822)
3.5 85.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
2.6 77.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.6 77.0 GO:0045499 chemorepellent activity(GO:0045499)
0.5 76.3 GO:0008017 microtubule binding(GO:0008017)
1.0 61.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
7.5 60.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.7 57.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
3.0 53.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.4 49.5 GO:0017124 SH3 domain binding(GO:0017124)
0.8 46.4 GO:0003777 microtubule motor activity(GO:0003777)
0.2 44.1 GO:0005525 GTP binding(GO:0005525)
0.6 42.0 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
5.8 40.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
1.8 40.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 35.2 GO:0008270 zinc ion binding(GO:0008270)
1.0 34.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.9 33.0 GO:0004364 glutathione transferase activity(GO:0004364)
1.6 32.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)