Motif ID: Sox21
Z-value: 0.513
Transcription factors associated with Sox21:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox21 | ENSMUSG00000061517.7 | Sox21 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox21 | mm10_v2_chr14_-_118237016_118237035 | 0.04 | 7.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.0 | GO:0070295 | renal water absorption(GO:0070295) |
| 0.7 | 4.1 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.5 | 2.6 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.5 | 4.1 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.4 | 1.2 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.4 | 1.1 | GO:0045349 | regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.3 | 1.0 | GO:0070649 | formin-nucleated actin cable assembly(GO:0070649) |
| 0.3 | 0.9 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.2 | 0.7 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.2 | 0.7 | GO:0021649 | vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835) |
| 0.2 | 1.0 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.2 | 0.7 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
| 0.2 | 2.5 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
| 0.2 | 1.0 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.2 | 1.2 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.2 | 0.7 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 0.2 | 3.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 0.9 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.1 | 0.8 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.1 | 0.4 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.1 | 0.7 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.4 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.1 | 2.9 | GO:0001504 | neurotransmitter uptake(GO:0001504) |
| 0.1 | 3.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 2.0 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.1 | 0.6 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 2.0 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.1 | 2.4 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.1 | 0.5 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.1 | 1.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 0.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.2 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.1 | 1.1 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 0.2 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.1 | 0.5 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.1 | 1.4 | GO:0095500 | synaptic transmission, cholinergic(GO:0007271) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.3 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.0 | 0.1 | GO:0060489 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.0 | 1.2 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.2 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.0 | 0.3 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
| 0.0 | 0.6 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.0 | 0.3 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 0.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.2 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.0 | 0.4 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.1 | GO:0000019 | regulation of mitotic recombination(GO:0000019) negative regulation of telomere capping(GO:1904354) |
| 0.0 | 0.4 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.0 | 0.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.1 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.0 | 2.1 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.0 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.0 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.5 | 2.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.3 | 2.6 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.2 | 0.7 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.2 | 0.7 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.2 | 3.1 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.1 | 1.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 1.0 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 5.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 5.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 2.9 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 0.3 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.0 | 0.1 | GO:0060187 | cell pole(GO:0060187) |
| 0.0 | 1.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 3.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 3.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.2 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 0.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.1 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 1.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.0 | GO:0032133 | chromosome passenger complex(GO:0032133) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.0 | GO:0015288 | porin activity(GO:0015288) |
| 0.6 | 3.7 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.4 | 2.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 2.6 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 1.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.2 | 0.7 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.2 | 1.2 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.2 | 0.6 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 0.2 | 1.0 | GO:0018121 | imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102) |
| 0.2 | 3.1 | GO:0050811 | GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811) |
| 0.2 | 1.4 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.2 | 5.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 2.9 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.1 | 1.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 0.7 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 0.4 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.6 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 0.7 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
| 0.1 | 0.9 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 2.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.6 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 2.5 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.0 | 1.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.5 | GO:0034943 | acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) very long-chain fatty acid-CoA ligase activity(GO:0031957) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409) |
| 0.0 | 0.7 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.4 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 1.5 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.5 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.0 | 1.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 1.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.4 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 0.1 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.0 | 0.1 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.0 | 0.2 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 2.9 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 1.2 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 1.1 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.2 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
