Motif ID: Sox21

Z-value: 0.513


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.047.2e-01Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_15403680 5.962 ENSMUST00000079081.6
 Aqp4
aquaporin 4
chrM_-_14060 3.485 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr5_-_70842617 3.136 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr7_+_51621830 2.903 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr2_-_73312701 2.855 ENSMUST00000058615.9
 Cir1
corepressor interacting with RBPJ, 1
chrM_+_14138 2.600 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr1_-_135167606 2.549 ENSMUST00000027682.8
 Gpr37l1
G protein-coupled receptor 37-like 1
chr12_+_38783503 2.355 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr11_+_32000452 2.283 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr9_-_79793378 2.087 ENSMUST00000034878.5
 Tmem30a
transmembrane protein 30A
chr13_-_85127514 2.072 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr9_-_79793507 2.043 ENSMUST00000120690.1
 Tmem30a
transmembrane protein 30A
chr2_+_136713444 2.030 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr7_-_25675047 1.917 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
 Tmem91


transmembrane protein 91


chr11_-_79504078 1.767 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr5_+_19907502 1.585 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr17_-_90088343 1.573 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr1_-_125913101 1.370 ENSMUST00000161361.1
 Lypd1
Ly6/Plaur domain containing 1
chr11_+_32000496 1.370 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr4_-_98383232 1.357 ENSMUST00000143116.1
ENSMUST00000030292.5
ENSMUST00000102793.4
 Tm2d1


TM2 domain containing 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 6.0 GO:0070295 renal water absorption(GO:0070295)
0.7 4.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.5 4.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 3.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 3.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 2.9 GO:0001504 neurotransmitter uptake(GO:0001504)
0.5 2.6 GO:0033762 response to glucagon(GO:0033762)
0.2 2.5 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.1 2.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 2.1 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 2.0 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 2.0 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 1.4 GO:0095500 synaptic transmission, cholinergic(GO:0007271) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.4 1.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.2 1.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 1.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 1.1 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 1.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.0 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.3 GO:0070469 respiratory chain(GO:0070469)
0.2 3.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.1 GO:0016607 nuclear speck(GO:0016607)
0.1 2.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 2.6 GO:0045275 respiratory chain complex III(GO:0045275)
0.5 2.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.5 2.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.2 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 0.7 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 0.7 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.0 GO:0015288 porin activity(GO:0015288)
0.2 5.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6 3.7 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 3.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.2 2.9 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 2.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.3 2.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 2.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 2.5 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 2.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 1.4 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 1.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 1.2 GO:0043022 ribosome binding(GO:0043022)
0.0 1.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 1.0 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)