Motif ID: Sox4

Z-value: 0.639


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_28953713-0.272.1e-02Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_45216671 5.423 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr7_-_103853199 5.029 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr17_+_75005523 4.739 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr17_-_70851189 4.242 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr18_-_62756275 3.676 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr2_-_33942111 3.564 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr3_+_131110350 3.459 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr1_+_135729147 3.184 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr13_-_97747373 3.034 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr12_-_54986363 2.884 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr4_+_41762309 2.787 ENSMUST00000108042.2
 Il11ra1
interleukin 11 receptor, alpha chain 1
chr13_-_97747399 2.756 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr9_+_85842852 2.575 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr17_-_35704000 2.415 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chrX_+_73639414 2.414 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr15_+_102296256 2.398 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr1_+_59482133 2.342 ENSMUST00000114246.2
ENSMUST00000037105.6
 Fzd7

frizzled homolog 7 (Drosophila)

chr11_-_115813621 2.328 ENSMUST00000041684.4
ENSMUST00000156812.1
 Caskin2

CASK-interacting protein 2

chr17_-_70853482 2.243 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_39557830 2.231 ENSMUST00000036877.3
ENSMUST00000154149.1
 Dennd2a

DENN/MADD domain containing 2A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.5 6.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 5.4 GO:0048368 notochord development(GO:0030903) lateral mesoderm development(GO:0048368)
1.0 5.0 GO:0015671 oxygen transport(GO:0015671)
0.2 4.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 4.4 GO:0006261 DNA-dependent DNA replication(GO:0006261)
1.2 3.5 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.2 2.8 GO:0046697 decidualization(GO:0046697)
0.7 2.7 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.2 2.5 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.3 2.4 GO:1901970 positive regulation of mitotic sister chromatid separation(GO:1901970)
0.1 2.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.6 2.3 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.6 2.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 2.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 2.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 2.0 GO:0001885 endothelial cell development(GO:0001885)
0.6 1.9 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 1.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.6 5.0 GO:0005833 hemoglobin complex(GO:0005833)
1.6 4.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.9 4.4 GO:0008623 CHRAC(GO:0008623)
0.3 3.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 2.7 GO:0008180 COP9 signalosome(GO:0008180)
0.6 2.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 2.4 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.1 GO:0031985 Golgi cisterna(GO:0031985)
0.4 1.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.6 1.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.0 1.4 GO:0043197 dendritic spine(GO:0043197)
0.1 1.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 1.0 GO:0033193 Lsd1/2 complex(GO:0033193)
0.3 1.0 GO:0097543 ciliary inversin compartment(GO:0097543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0070410 co-SMAD binding(GO:0070410)
0.7 6.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 5.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.3 5.0 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.2 4.7 GO:0050436 microfibril binding(GO:0050436)
0.0 3.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 3.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.7 2.8 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.9 2.7 GO:0043532 angiostatin binding(GO:0043532)
0.1 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.1 GO:0097110 scaffold protein binding(GO:0097110)
0.4 1.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.7 GO:0030165 PDZ domain binding(GO:0030165)
0.5 1.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 1.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)