Motif ID: Sox4
Z-value: 0.639
Transcription factors associated with Sox4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox4 | ENSMUSG00000076431.4 | Sox4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox4 | mm10_v2_chr13_-_28953690_28953713 | -0.27 | 2.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 1.0 | 5.0 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.7 | 2.7 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 0.6 | 1.9 | GO:0046671 | negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.6 | 2.3 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
| 0.6 | 2.3 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.5 | 6.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.5 | 1.4 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.4 | 6.7 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.3 | 1.0 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.3 | 1.0 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 0.3 | 0.9 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 0.3 | 1.7 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.3 | 2.4 | GO:1901970 | positive regulation of mitotic sister chromatid separation(GO:1901970) |
| 0.3 | 0.8 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
| 0.2 | 5.4 | GO:0048368 | notochord development(GO:0030903) lateral mesoderm development(GO:0048368) |
| 0.2 | 1.7 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.2 | 2.8 | GO:0046697 | decidualization(GO:0046697) |
| 0.2 | 0.4 | GO:0033484 | nitric oxide homeostasis(GO:0033484) |
| 0.2 | 2.5 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.2 | 1.2 | GO:1902410 | mitotic cytokinetic process(GO:1902410) |
| 0.2 | 0.6 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) |
| 0.2 | 1.9 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
| 0.2 | 0.9 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
| 0.2 | 4.7 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.2 | 1.4 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.2 | 0.5 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.2 | 1.2 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.1 | 0.7 | GO:0038030 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.1 | 2.4 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 2.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 1.7 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.1 | 1.3 | GO:0048853 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) forebrain morphogenesis(GO:0048853) |
| 0.1 | 0.9 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 1.1 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
| 0.1 | 0.4 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 0.9 | GO:0061525 | hindgut development(GO:0061525) |
| 0.1 | 0.6 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.1 | 0.5 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.1 | 0.7 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 1.3 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 1.1 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.1 | 1.5 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.2 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 0.0 | 0.3 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.0 | 0.2 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) regulation of dendritic spine maintenance(GO:1902950) positive regulation of dendritic spine maintenance(GO:1902952) |
| 0.0 | 4.4 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.6 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 2.2 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 2.0 | GO:0001885 | endothelial cell development(GO:0001885) |
| 0.0 | 2.2 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 1.8 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 1.7 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 0.3 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 1.0 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 0.4 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.4 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.8 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.9 | 4.4 | GO:0008623 | CHRAC(GO:0008623) |
| 0.6 | 5.0 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.6 | 2.4 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.6 | 1.7 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.4 | 1.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.3 | 1.0 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.3 | 1.0 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 0.3 | 3.5 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 1.2 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 0.7 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 0.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 2.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 0.9 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 0.7 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 2.4 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 0.3 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 2.1 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 1.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 1.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 5.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.9 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 1.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.2 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 1.4 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 0.9 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.0 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
| 1.2 | 4.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.9 | 2.7 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.7 | 2.8 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
| 0.7 | 6.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.6 | 3.5 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.5 | 1.6 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.4 | 1.9 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.4 | 1.5 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.3 | 6.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 1.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 1.4 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 2.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.3 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.1 | 1.2 | GO:0004438 | phosphatidylinositol-3-phosphatase activity(GO:0004438) |
| 0.1 | 1.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.2 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 0.1 | 2.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 1.0 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 0.7 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 2.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.3 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.0 | 5.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.4 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.0 | 0.8 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 1.4 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 2.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.5 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 1.7 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 2.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 1.1 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.7 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.6 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.8 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 3.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.9 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.6 | GO:0044824 | integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824) |
| 0.0 | 0.8 | GO:0002039 | p53 binding(GO:0002039) |
