Motif ID: Sox8

Z-value: 0.375


Transcription factors associated with Sox8:

Gene SymbolEntrez IDGene Name
Sox8 ENSMUSG00000024176.4 Sox8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_25570694-0.642.5e-09Click!


Activity profile for motif Sox8.

activity profile for motif Sox8


Sorted Z-values histogram for motif Sox8

Sorted Z-values for motif Sox8



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_102010138 2.498 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr13_-_66227573 1.553 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr8_+_34807287 1.526 ENSMUST00000033930.4
 Dusp4
dual specificity phosphatase 4
chr18_-_62741387 1.502 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr11_+_32286946 1.330 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chrX_+_134404780 1.290 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr15_-_97020322 1.120 ENSMUST00000166223.1
 Slc38a4
solute carrier family 38, member 4
chr4_+_43401232 1.108 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2
chr7_-_126800354 1.049 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr13_-_66852017 0.992 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr13_-_19395728 0.972 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like
chr11_+_97415527 0.953 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr18_+_36952621 0.947 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr19_+_24875679 0.909 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr13_+_93304799 0.823 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr11_-_26591729 0.813 ENSMUST00000109504.1
 Vrk2
vaccinia related kinase 2
chr7_-_126800036 0.762 ENSMUST00000133514.1
ENSMUST00000151137.1
 Aldoa

aldolase A, fructose-bisphosphate

chr4_-_134245579 0.729 ENSMUST00000030644.7
 Zfp593
zinc finger protein 593
chr6_-_119467210 0.710 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B
chr7_-_42578588 0.625 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr11_+_69991061 0.622 ENSMUST00000018711.8
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr13_+_65512678 0.580 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr10_-_128180265 0.553 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr11_+_113659283 0.537 ENSMUST00000137878.1
 Cog1
component of oligomeric golgi complex 1
chr3_+_65109343 0.524 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr15_-_89149557 0.522 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr11_+_69991633 0.512 ENSMUST00000108592.1
 Gabarap
gamma-aminobutyric acid receptor associated protein
chr14_-_49783327 0.507 ENSMUST00000118129.1
ENSMUST00000036972.6
 3632451O06Rik

RIKEN cDNA 3632451O06 gene

chr4_+_124657646 0.503 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr8_-_33747724 0.501 ENSMUST00000179364.1
 Smim18
small integral membrane protein 18
chr4_-_129578535 0.435 ENSMUST00000052835.8
 Fam167b
family with sequence similarity 167, member B
chr18_+_80046854 0.374 ENSMUST00000070219.7
 Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr13_-_30950298 0.373 ENSMUST00000102946.1
 Exoc2
exocyst complex component 2
chr1_+_109993982 0.315 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr2_+_69789647 0.307 ENSMUST00000112266.1
 Phospho2
phosphatase, orphan 2
chr11_-_43747963 0.291 ENSMUST00000048578.2
ENSMUST00000109278.1
 Ttc1

tetratricopeptide repeat domain 1

chrX_-_162643629 0.290 ENSMUST00000112334.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr4_+_154142363 0.285 ENSMUST00000030895.5
 Wrap73
WD repeat containing, antisense to Trp73
chr3_-_8667033 0.283 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr2_-_37647199 0.268 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein
chr10_+_82378593 0.254 ENSMUST00000165906.1
 Gm4924
predicted gene 4924
chrX_-_162643575 0.243 ENSMUST00000101102.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chrX_-_72918284 0.241 ENSMUST00000152200.1
 Cetn2
centrin 2
chr9_-_4309432 0.233 ENSMUST00000051589.7
 Aasdhppt
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr1_+_109983737 0.230 ENSMUST00000172005.1
 Cdh7
cadherin 7, type 2
chr2_+_69789621 0.217 ENSMUST00000151298.1
ENSMUST00000028494.2
 Phospho2

phosphatase, orphan 2

chr2_-_84715160 0.216 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr13_+_93304066 0.210 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr9_-_32541589 0.178 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr13_-_66851513 0.153 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr11_-_69758630 0.132 ENSMUST00000058470.9
 Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
chr11_-_118909487 0.132 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
 Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr4_-_58553553 0.112 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr4_-_116405986 0.111 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr2_+_18677002 0.084 ENSMUST00000028071.6
 Bmi1
Bmi1 polycomb ring finger oncogene
chr11_-_46166397 0.059 ENSMUST00000020679.2
 Nipal4
NIPA-like domain containing 4
chr2_+_4400958 0.058 ENSMUST00000075767.7
 Frmd4a
FERM domain containing 4A
chr2_+_176236860 0.056 ENSMUST00000166464.1
 2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr9_+_110052016 0.053 ENSMUST00000164930.1
ENSMUST00000163979.1
 Map4

microtubule-associated protein 4

chr11_-_110095974 0.019 ENSMUST00000100287.2
 Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr15_-_103215285 0.001 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0060467 negative regulation of fertilization(GO:0060467)
0.2 1.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.5 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.1 2.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 1.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.2 GO:0006553 lysine metabolic process(GO:0006553)
0.1 0.4 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.8 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 1.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.1 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.5 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.1 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 0.5 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 1.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 1.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 1.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.0 2.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 1.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)