Motif ID: Sp1

Z-value: 1.624


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_1024063800.085.3e-01Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 18.058 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr2_+_172345565 17.865 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr1_-_56971762 16.248 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr12_-_100725028 14.960 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr12_+_12262139 14.355 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chr9_+_44043384 14.240 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr5_-_109558957 13.540 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr8_-_29219338 13.495 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr5_+_134986191 13.368 ENSMUST00000094245.2
 Cldn3
claudin 3
chr4_-_133498538 12.543 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr8_-_84800344 12.329 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr4_-_148130678 12.011 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr1_-_56972437 11.943 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr7_+_57591147 11.858 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr10_+_80167778 11.539 ENSMUST00000105365.2
ENSMUST00000054666.6
 Cirbp

cold inducible RNA binding protein

chr16_+_93711907 11.497 ENSMUST00000045004.9
 Dopey2
dopey family member 2
chr15_+_81811414 11.397 ENSMUST00000023024.7
 Tef
thyrotroph embryonic factor
chr2_-_33130565 11.069 ENSMUST00000124000.1
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_73386396 11.031 ENSMUST00000112044.1
ENSMUST00000112043.1
ENSMUST00000076463.5
 Gpr155


G protein-coupled receptor 155


chr4_-_120287349 11.007 ENSMUST00000102656.3
 Foxo6
forkhead box O6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 978 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 35.8 GO:0071805 potassium ion transmembrane transport(GO:0071805)
2.5 35.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.9 34.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
2.6 34.0 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.9 31.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.2 28.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.8 28.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
1.7 26.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
4.2 24.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.6 24.7 GO:0030517 negative regulation of axon extension(GO:0030517)
0.7 21.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
1.7 21.8 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.4 20.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.9 20.4 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.5 19.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
2.2 19.7 GO:0071420 cellular response to histamine(GO:0071420)
1.9 19.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.7 19.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
1.0 19.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
1.0 19.0 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 594.0 GO:0016021 integral component of membrane(GO:0016021)
0.5 90.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 83.3 GO:0055037 recycling endosome(GO:0055037)
0.4 62.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 56.1 GO:0000139 Golgi membrane(GO:0000139)
0.4 50.2 GO:0070382 exocytic vesicle(GO:0070382)
0.4 48.3 GO:0031225 anchored component of membrane(GO:0031225)
1.3 46.3 GO:0032809 neuronal cell body membrane(GO:0032809)
1.2 43.6 GO:0048786 presynaptic active zone(GO:0048786)
0.8 40.1 GO:0005905 clathrin-coated pit(GO:0005905)
1.1 37.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 36.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4 35.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.4 33.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.7 32.5 GO:0042734 presynaptic membrane(GO:0042734)
0.7 31.5 GO:0031901 early endosome membrane(GO:0031901)
0.4 30.8 GO:0005770 late endosome(GO:0005770)
0.7 29.9 GO:0031201 SNARE complex(GO:0031201)
0.2 29.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
3.0 29.7 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 564 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 65.6 GO:0005096 GTPase activator activity(GO:0005096)
0.5 56.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.9 44.4 GO:0005246 calcium channel regulator activity(GO:0005246)
1.3 41.0 GO:0022824 transmitter-gated ion channel activity(GO:0022824) transmitter-gated channel activity(GO:0022835)
0.9 41.0 GO:0045296 cadherin binding(GO:0045296)
2.0 38.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 37.5 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
1.2 32.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.9 32.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.5 30.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.7 28.9 GO:0005262 calcium channel activity(GO:0005262)
0.3 27.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
3.1 24.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
4.0 24.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 23.5 GO:0051015 actin filament binding(GO:0051015)
0.6 23.2 GO:0005484 SNAP receptor activity(GO:0005484)
1.1 23.0 GO:0031489 myosin V binding(GO:0031489)
1.0 22.9 GO:0017075 syntaxin-1 binding(GO:0017075)
2.8 22.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.7 20.8 GO:0030215 semaphorin receptor binding(GO:0030215)