Motif ID: Spdef

Z-value: 0.513


Transcription factors associated with Spdef:

Gene SymbolEntrez IDGene Name
Spdef ENSMUSG00000024215.7 Spdef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spdefmm10_v2_chr17_-_27728889_27728956-0.104.3e-01Click!


Activity profile for motif Spdef.

activity profile for motif Spdef


Sorted Z-values histogram for motif Spdef

Sorted Z-values for motif Spdef



Network of associatons between targets according to the STRING database.



First level regulatory network of Spdef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 4.527 ENSMUST00000165033.1
 Egr1
early growth response 1
chr14_+_54254124 4.199 ENSMUST00000180359.1
 Abhd4
abhydrolase domain containing 4
chr14_-_70207637 3.856 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr14_+_54936456 3.241 ENSMUST00000037814.6
 Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr3_+_27938638 3.031 ENSMUST00000120834.1
 Pld1
phospholipase D1
chr10_-_58675631 2.996 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr11_-_55419898 2.971 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr13_-_60177357 2.837 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chrX_+_100625737 2.504 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr11_+_78176711 2.440 ENSMUST00000098545.5
 Tlcd1
TLC domain containing 1
chr9_+_80165079 2.423 ENSMUST00000184480.1
 Myo6
myosin VI
chr13_-_19619820 2.329 ENSMUST00000002885.6
 Epdr1
ependymin related protein 1 (zebrafish)
chr1_+_84839833 2.252 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr4_+_156203292 2.247 ENSMUST00000105140.2
 AW011738
expressed sequence AW011738
chr9_-_65908676 2.216 ENSMUST00000119245.1
ENSMUST00000134338.1
ENSMUST00000179395.1
 Trip4


thyroid hormone receptor interactor 4


chr9_+_80165013 2.082 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr10_-_93311073 2.069 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr6_-_95718800 2.060 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr2_+_145785980 2.050 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr1_+_61638819 1.957 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.5 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 4.5 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 4.2 GO:0019915 lipid storage(GO:0019915)
0.1 4.0 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.1 3.8 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
1.2 3.6 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.2 3.2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.8 3.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
1.0 3.0 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.4 3.0 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 3.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.3 2.8 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3 2.8 GO:0042473 outer ear morphogenesis(GO:0042473)
0.0 2.7 GO:0008033 tRNA processing(GO:0008033)
0.4 2.5 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 2.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.4 GO:0031529 ruffle organization(GO:0031529)
0.3 2.3 GO:0006105 succinate metabolic process(GO:0006105)
0.1 2.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 2.3 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0072562 blood microparticle(GO:0072562)
0.2 4.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 4.2 GO:0005811 lipid particle(GO:0005811)
0.1 3.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 3.6 GO:0000322 storage vacuole(GO:0000322)
0.1 3.3 GO:0005871 kinesin complex(GO:0005871)
0.7 3.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.0 GO:0031985 Golgi cisterna(GO:0031985)
0.1 2.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.5 GO:0032420 stereocilium(GO:0032420)
0.3 2.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.3 2.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 2.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.9 GO:0005681 spliceosomal complex(GO:0005681)
0.6 1.8 GO:0000801 central element(GO:0000801)
0.6 1.8 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 1.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.8 GO:0001726 ruffle(GO:0001726)
0.0 1.6 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 5.6 GO:0017166 vinculin binding(GO:0017166)
0.0 4.3 GO:0003774 motor activity(GO:0003774)
0.1 4.2 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.9 3.6 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 3.6 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 3.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.4 3.0 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 2.9 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 2.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.6 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.2 2.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.3 GO:0005125 cytokine activity(GO:0005125)
0.5 2.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 2.1 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.1 2.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.7 2.0 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.4 1.9 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.1 1.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)