Motif ID: Spi1

Z-value: 1.337


Transcription factors associated with Spi1:

Gene SymbolEntrez IDGene Name
Spi1 ENSMUSG00000002111.8 Spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spi1mm10_v2_chr2_+_91082362_91082390-0.317.9e-03Click!


Activity profile for motif Spi1.

activity profile for motif Spi1


Sorted Z-values histogram for motif Spi1

Sorted Z-values for motif Spi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Spi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 29.055 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_-_95904683 13.885 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr11_+_98412461 13.533 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr2_+_105675478 13.120 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr7_-_102250086 13.066 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr7_-_127218303 11.842 ENSMUST00000106313.1
 Sept1
septin 1
chr2_+_105682463 11.723 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr16_-_38713235 11.658 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr15_-_103366763 11.607 ENSMUST00000023128.6
 Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr7_-_127218390 11.449 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr6_+_124830217 10.631 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr4_+_136143497 10.332 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr12_+_118846329 10.229 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr3_+_89436699 10.034 ENSMUST00000038942.3
ENSMUST00000130858.1
 Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr2_+_105675429 9.477 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr11_+_32276400 9.251 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr17_+_85620816 8.945 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr2_+_84840612 8.898 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr6_-_72789240 8.808 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr15_-_79164477 8.627 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 718 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.2 43.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.5 39.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
6.9 34.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.8 26.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
5.8 23.3 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
2.6 20.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
4.8 19.2 GO:0045608 inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608)
0.8 18.8 GO:0006270 DNA replication initiation(GO:0006270)
1.9 16.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.9 16.6 GO:0051127 positive regulation of actin nucleation(GO:0051127)
5.4 16.2 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
2.0 15.9 GO:0015670 carbon dioxide transport(GO:0015670)
1.2 15.8 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
4.8 14.5 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) axial mesoderm morphogenesis(GO:0048319)
0.9 14.4 GO:1900027 regulation of ruffle assembly(GO:1900027)
3.6 14.2 GO:0000255 allantoin metabolic process(GO:0000255)
3.4 13.7 GO:1903416 response to glycoside(GO:1903416)
1.7 13.7 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
4.5 13.5 GO:0044849 estrous cycle(GO:0044849)
1.4 13.5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 291 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 136.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 63.2 GO:0005654 nucleoplasm(GO:0005654)
0.8 37.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 31.9 GO:0005925 focal adhesion(GO:0005925)
0.1 28.4 GO:0005730 nucleolus(GO:0005730)
0.0 26.2 GO:1903561 extracellular vesicle(GO:1903561)
0.1 24.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
2.6 23.6 GO:0072687 meiotic spindle(GO:0072687)
1.6 18.9 GO:0043219 lateral loop(GO:0043219)
1.7 18.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.8 18.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 18.2 GO:0016459 myosin complex(GO:0016459)
0.3 17.7 GO:0016328 lateral plasma membrane(GO:0016328)
2.9 17.2 GO:0031262 Ndc80 complex(GO:0031262)
1.8 15.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 15.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
1.4 14.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 14.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.6 13.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
3.2 12.9 GO:0032127 dense core granule membrane(GO:0032127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 429 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 70.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 57.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.0 45.0 GO:0070410 co-SMAD binding(GO:0070410)
0.1 38.7 GO:0005525 GTP binding(GO:0005525)
0.8 38.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
2.2 37.1 GO:0017166 vinculin binding(GO:0017166)
0.1 26.4 GO:0003779 actin binding(GO:0003779)
0.1 22.6 GO:0008134 transcription factor binding(GO:0008134)
0.1 21.1 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 20.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 19.3 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.3 19.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 16.7 GO:0000049 tRNA binding(GO:0000049)
2.8 16.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 15.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.2 13.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
1.7 13.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 13.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 12.9 GO:0001047 core promoter binding(GO:0001047)
0.3 12.6 GO:0003678 DNA helicase activity(GO:0003678)