Motif ID: Spib

Z-value: 1.511


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib



Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 39.650 ENSMUST00000100572.3
 Sla
src-like adaptor
chr6_+_137410721 14.798 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr5_+_81021202 14.490 ENSMUST00000117253.1
ENSMUST00000120128.1
 Lphn3

latrophilin 3

chr4_-_136898803 11.814 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr4_-_136892867 11.737 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_-_136886187 11.731 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr2_+_121357714 11.629 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr12_-_78980758 10.411 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr1_-_171059390 10.142 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr2_+_55437100 9.767 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr17_+_93199348 9.746 ENSMUST00000064775.6
 Adcyap1
adenylate cyclase activating polypeptide 1
chr10_+_81257277 9.502 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr13_+_109903089 8.937 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr3_-_87263518 8.798 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chrX_-_43167817 8.765 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr2_+_121358591 8.741 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr2_+_32721055 8.463 ENSMUST00000074248.4
 Sh2d3c
SH2 domain containing 3C
chr1_-_22315792 8.277 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr12_-_86988676 8.171 ENSMUST00000095521.2
 Zdhhc22
zinc finger, DHHC-type containing 22
chr3_-_123672321 8.122 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 35.3 GO:0006958 complement activation, classical pathway(GO:0006958)
6.7 20.0 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.2 19.3 GO:0032091 negative regulation of protein binding(GO:0032091)
3.1 18.5 GO:0032796 uropod organization(GO:0032796)
4.0 15.8 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
3.0 14.8 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
3.5 14.0 GO:1904425 negative regulation of GTP binding(GO:1904425)
2.5 12.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 11.0 GO:0010107 potassium ion import(GO:0010107)
2.2 10.8 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 10.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 10.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 9.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.7 8.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
2.1 8.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 8.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.4 8.1 GO:0007035 vacuolar acidification(GO:0007035)
0.9 7.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
1.0 7.8 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 7.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 39.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 39.3 GO:0005768 endosome(GO:0005768)
0.4 31.1 GO:0005581 collagen trimer(GO:0005581)
0.0 23.2 GO:0045202 synapse(GO:0045202)
0.0 20.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 19.8 GO:0043209 myelin sheath(GO:0043209)
0.8 19.5 GO:0001891 phagocytic cup(GO:0001891)
0.4 16.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 14.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.6 11.2 GO:0071564 npBAF complex(GO:0071564)
0.1 10.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
2.6 10.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 9.7 GO:0043195 terminal bouton(GO:0043195)
0.9 9.0 GO:0071439 clathrin complex(GO:0071439)
0.1 9.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 8.3 GO:0048786 presynaptic active zone(GO:0048786)
1.2 8.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.6 7.8 GO:0042581 specific granule(GO:0042581)
0.4 6.0 GO:0031143 pseudopodium(GO:0031143)
0.0 5.3 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.2 26.1 GO:0019864 IgG binding(GO:0019864)
5.1 20.4 GO:0004111 creatine kinase activity(GO:0004111)
0.2 19.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 18.6 GO:0017124 SH3 domain binding(GO:0017124)
1.9 18.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 17.6 GO:0030246 carbohydrate binding(GO:0030246)
0.1 16.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 13.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
1.8 12.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.9 11.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 10.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.9 10.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
2.0 9.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6 9.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 9.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.0 9.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 8.9 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.9 8.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.2 8.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.6 7.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)