Motif ID: Spic

Z-value: 1.026


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_88683025-0.113.8e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 10.707 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_-_136886187 8.920 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr1_-_56978534 7.967 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_171234290 7.664 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr6_+_5725639 7.207 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr3_+_95526777 6.023 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr4_+_130913120 5.871 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr15_-_66812593 5.832 ENSMUST00000100572.3
 Sla
src-like adaptor
chr6_+_137410721 5.733 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr4_+_130913264 5.544 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr6_-_136941694 4.126 ENSMUST00000032344.5
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr19_+_12460749 4.117 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr1_-_170976112 3.939 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
 Fcgr2b


Fc receptor, IgG, low affinity IIb


chr14_+_80000292 3.789 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr10_-_117282262 3.462 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr7_-_126704179 3.412 ENSMUST00000106364.1
 Coro1a
coronin, actin binding protein 1A
chr7_-_126704736 3.348 ENSMUST00000131415.1
 Coro1a
coronin, actin binding protein 1A
chr1_-_171059390 3.205 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr8_+_66386292 3.186 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr7_-_126704522 3.123 ENSMUST00000135087.1
 Coro1a
coronin, actin binding protein 1A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 12.5 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
1.6 11.0 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.6 9.9 GO:0032796 uropod organization(GO:0032796)
1.9 9.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.6 8.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.5 8.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 7.9 GO:0030574 collagen catabolic process(GO:0030574)
1.3 6.3 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.1 6.0 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.1 4.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
1.3 3.9 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.4 3.9 GO:0071569 protein ufmylation(GO:0071569)
0.2 3.5 GO:0019835 cytolysis(GO:0019835)
1.1 3.4 GO:2000562 positive regulation of defense response to bacterium(GO:1900426) negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.1 3.4 GO:0042255 ribosome assembly(GO:0042255)
0.2 3.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 3.2 GO:0010107 potassium ion import(GO:0010107)
0.8 3.1 GO:0050904 diapedesis(GO:0050904)
0.1 3.1 GO:0045026 plasma membrane fusion(GO:0045026)
1.0 3.0 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.8 GO:0005829 cytosol(GO:0005829)
0.3 18.9 GO:0005581 collagen trimer(GO:0005581)
0.1 18.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 10.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 9.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 7.9 GO:0009986 cell surface(GO:0009986)
0.0 6.7 GO:0005768 endosome(GO:0005768)
0.1 5.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 5.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 5.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 5.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 5.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 3.8 GO:0042581 specific granule(GO:0042581)
0.7 3.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.6 3.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.6 3.0 GO:1990745 EARP complex(GO:1990745)
0.5 2.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.6 2.3 GO:0044307 dendritic branch(GO:0044307)
0.1 2.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.4 GO:0019864 IgG binding(GO:0019864)
1.0 9.9 GO:0032036 myosin heavy chain binding(GO:0032036)
1.3 9.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.4 7.2 GO:0045503 dynein light chain binding(GO:0045503)
0.0 5.9 GO:0005525 GTP binding(GO:0005525)
0.2 5.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 5.2 GO:0043236 laminin binding(GO:0043236)
0.7 4.3 GO:0016936 galactoside binding(GO:0016936)
0.1 4.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.8 GO:0045296 cadherin binding(GO:0045296)
0.0 3.6 GO:0019905 syntaxin binding(GO:0019905)
0.1 3.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 3.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 3.3 GO:0042287 MHC protein binding(GO:0042287)
0.3 2.9 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.4 2.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 2.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 2.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)