Motif ID: Stat1
Z-value: 0.844
Transcription factors associated with Stat1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Stat1 | ENSMUSG00000026104.8 | Stat1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Stat1 | mm10_v2_chr1_+_52119438_52119499 | -0.29 | 1.7e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 12.3 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.9 | 5.7 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 1.8 | 20.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 1.4 | 4.3 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 1.3 | 7.9 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 1.2 | 3.7 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.9 | 2.6 | GO:1901731 | calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731) |
| 0.8 | 3.2 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.8 | 2.3 | GO:0043201 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) |
| 0.7 | 3.6 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.7 | 2.1 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.6 | 13.5 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.5 | 1.6 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.5 | 2.0 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.5 | 9.5 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.5 | 6.6 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.4 | 3.0 | GO:0015862 | uridine transport(GO:0015862) |
| 0.4 | 2.1 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
| 0.4 | 1.7 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.4 | 1.5 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.4 | 4.9 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.3 | 9.1 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.3 | 3.4 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.3 | 1.2 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.3 | 6.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.3 | 2.2 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 0.3 | 1.1 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
| 0.3 | 7.4 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.2 | 1.2 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.2 | 2.4 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.2 | 1.9 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.2 | 0.7 | GO:1904154 | trimming of terminal mannose on B branch(GO:0036509) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.2 | 1.8 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.2 | 15.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.2 | 2.0 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.2 | 1.9 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.2 | 0.5 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.2 | 1.5 | GO:0032026 | response to magnesium ion(GO:0032026) |
| 0.2 | 18.8 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844) |
| 0.2 | 1.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 1.5 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.1 | 1.4 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.1 | 1.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 5.1 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 0.3 | GO:0001803 | type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
| 0.1 | 1.0 | GO:0045351 | type I interferon biosynthetic process(GO:0045351) |
| 0.1 | 0.5 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 0.4 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
| 0.1 | 1.3 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.1 | 4.1 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.1 | 5.5 | GO:0050729 | positive regulation of inflammatory response(GO:0050729) |
| 0.1 | 1.3 | GO:0071364 | cellular response to platelet-derived growth factor stimulus(GO:0036120) cellular response to epidermal growth factor stimulus(GO:0071364) |
| 0.1 | 2.3 | GO:0071470 | cellular response to osmotic stress(GO:0071470) |
| 0.1 | 2.5 | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity(GO:0043551) |
| 0.1 | 1.6 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 1.7 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.1 | 1.4 | GO:0070200 | establishment of protein localization to telomere(GO:0070200) |
| 0.1 | 1.5 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 0.6 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 0.6 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.1 | 2.9 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.1 | 1.5 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.0 | 2.7 | GO:0006998 | nuclear envelope organization(GO:0006998) |
| 0.0 | 0.1 | GO:0060489 | epicardial cell to mesenchymal cell transition(GO:0003347) establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) |
| 0.0 | 0.3 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 0.0 | 2.1 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.0 | 1.2 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.0 | 0.7 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.0 | 1.0 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.0 | 7.1 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 5.4 | GO:0006275 | regulation of DNA replication(GO:0006275) |
| 0.0 | 0.8 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.0 | 0.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.0 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.0 | 2.7 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 0.5 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.0 | 2.6 | GO:0048839 | inner ear development(GO:0048839) |
| 0.0 | 0.4 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.3 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
| 0.0 | 0.5 | GO:0097202 | activation of cysteine-type endopeptidase activity(GO:0097202) |
| 0.0 | 2.0 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 22.6 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 1.1 | 6.6 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.7 | 2.9 | GO:0090537 | CERF complex(GO:0090537) |
| 0.7 | 3.4 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.7 | 13.5 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.7 | 2.0 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.7 | 2.6 | GO:0031673 | H zone(GO:0031673) |
| 0.6 | 4.1 | GO:0070695 | FHF complex(GO:0070695) |
| 0.5 | 1.5 | GO:0044299 | C-fiber(GO:0044299) |
| 0.5 | 3.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.4 | 1.8 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.4 | 7.7 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.4 | 5.3 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.3 | 2.2 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.3 | 1.2 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.3 | 1.4 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.2 | 5.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 3.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 1.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 7.4 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 1.2 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 1.9 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.1 | 1.1 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 0.5 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 4.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 2.5 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 1.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 0.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 2.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 2.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 5.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 3.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 0.1 | GO:0060187 | cell pole(GO:0060187) |
| 0.0 | 2.3 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 2.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.7 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 3.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.5 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 5.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 2.6 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 2.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 13.5 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 1.9 | 9.5 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 1.5 | 12.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 1.3 | 7.9 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 1.0 | 2.9 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
| 0.9 | 3.6 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.8 | 3.2 | GO:0023029 | peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980) |
| 0.7 | 20.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.6 | 5.7 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.6 | 2.5 | GO:0019962 | interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962) interleukin-20 binding(GO:0042015) |
| 0.5 | 3.6 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.5 | 1.9 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.5 | 3.2 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.4 | 6.9 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.4 | 2.3 | GO:0070728 | leucine binding(GO:0070728) |
| 0.4 | 9.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.3 | 3.8 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.3 | 1.6 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.3 | 3.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 5.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.2 | 1.9 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.2 | 1.2 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.2 | 6.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.2 | 0.5 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.2 | 1.4 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 3.0 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 1.5 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 2.9 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 5.3 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.1 | 0.7 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.1 | 11.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 1.7 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 0.6 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 1.3 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 4.9 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
| 0.1 | 0.5 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 7.4 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 0.3 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 2.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 1.3 | GO:0023026 | MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026) |
| 0.1 | 0.7 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 1.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 0.4 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.1 | 1.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.1 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.1 | 2.1 | GO:0043531 | ADP binding(GO:0043531) |
| 0.1 | 3.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 5.5 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492) |
| 0.0 | 1.5 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.0 | 1.2 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 1.1 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 7.9 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 4.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.1 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.0 | 3.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.6 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 11.8 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 3.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 2.3 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 1.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 2.4 | GO:0003729 | mRNA binding(GO:0003729) |
| 0.0 | 0.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
