Motif ID: Stat1

Z-value: 0.844


Transcription factors associated with Stat1:

Gene SymbolEntrez IDGene Name
Stat1 ENSMUSG00000026104.8 Stat1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat1mm10_v2_chr1_+_52119438_52119499-0.291.7e-02Click!


Activity profile for motif Stat1.

activity profile for motif Stat1


Sorted Z-values histogram for motif Stat1

Sorted Z-values for motif Stat1



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat1

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 13.495 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 11.344 ENSMUST00000166381.1
Cdr1
cerebellar degeneration related antigen 1
chr16_-_42340595 7.853 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr7_+_45783883 7.844 ENSMUST00000072580.5
Lmtk3
lemur tyrosine kinase 3
chr7_+_45783686 7.808 ENSMUST00000118564.1
ENSMUST00000133428.1
Lmtk3

lemur tyrosine kinase 3

chr10_+_69925766 7.443 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
Ank3


ankyrin 3, epithelial


chr6_+_115134899 7.435 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2

synapsin II

chr10_+_69925954 7.204 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
Ank3


ankyrin 3, epithelial


chr4_+_43401232 6.890 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr2_+_178193075 6.873 ENSMUST00000103065.1
Phactr3
phosphatase and actin regulator 3
chr3_-_10440054 6.608 ENSMUST00000099223.4
ENSMUST00000029047.6
Snx16

sorting nexin 16

chr18_-_33463615 6.597 ENSMUST00000051087.8
Nrep
neuronal regeneration related protein
chr18_-_33463747 6.578 ENSMUST00000171533.1
Nrep
neuronal regeneration related protein
chr1_-_155417394 6.272 ENSMUST00000111775.1
ENSMUST00000111774.1
Xpr1

xenotropic and polytropic retrovirus receptor 1

chr18_-_33464007 6.123 ENSMUST00000168890.1
Nrep
neuronal regeneration related protein
chr1_-_155417283 6.016 ENSMUST00000027741.5
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr19_-_46327121 5.828 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd

pleckstrin and Sec7 domain containing

chr9_-_96719404 5.736 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr16_-_74411776 5.713 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr10_+_69925800 5.311 ENSMUST00000182029.1
Ank3
ankyrin 3, epithelial

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 20.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 18.8 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.2 15.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 13.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.0 12.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.5 9.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.3 9.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
1.3 7.9 GO:0016198 axon choice point recognition(GO:0016198)
0.3 7.4 GO:0034340 response to type I interferon(GO:0034340)
0.0 7.1 GO:0048813 dendrite morphogenesis(GO:0048813)
0.3 6.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 6.6 GO:0006622 protein targeting to lysosome(GO:0006622)
1.9 5.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 5.5 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 5.4 GO:0006275 regulation of DNA replication(GO:0006275)
0.1 5.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 4.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
1.4 4.3 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 4.1 GO:0045022 early endosome to late endosome transport(GO:0045022)
1.2 3.7 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 22.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.7 13.5 GO:0032279 asymmetric synapse(GO:0032279)
0.4 7.7 GO:0031527 filopodium membrane(GO:0031527)
0.1 7.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.1 6.6 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 5.7 GO:0030673 axolemma(GO:0030673)
0.4 5.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 5.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 5.1 GO:0055037 recycling endosome(GO:0055037)
0.1 4.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 4.1 GO:0070695 FHF complex(GO:0070695)
0.2 3.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 3.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.7 3.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 3.3 GO:0031965 nuclear membrane(GO:0031965)
0.5 3.2 GO:0042825 TAP complex(GO:0042825)
0.7 2.9 GO:0090537 CERF complex(GO:0090537)
0.0 2.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 2.6 GO:0031673 H zone(GO:0031673)
0.0 2.6 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 20.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
2.2 13.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.5 12.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 11.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 11.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
1.9 9.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.4 9.3 GO:0008327 methyl-CpG binding(GO:0008327)
1.3 7.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 7.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 7.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 6.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.2 6.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6 5.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 5.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 5.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.2 5.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 4.9 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 4.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 3.8 GO:0001846 opsonin binding(GO:0001846)
0.3 3.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)